Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature

Zhang,Li‑Na; Xue,Xin‑Ying; Wang,Na; Wang,Jian‑Xin

doi:10.3892/ol.2012.923

Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature

Authors:
- Li‑Na Zhang
- Xin‑Ying Xue
- Na Wang
- Jian‑Xin Wang
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Affiliations: Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing 100853, P.R. China
Published online on: September 20, 2012 https://doi.org/10.3892/ol.2012.923
Pages: 1366-1370

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Abstract

Primary pulmonary amyloidosis is a relatively rare condition, characterized by amyloid deposition in the lungs and other associated structures. We report a case of primary nodular parenchymal pulmonary amyloidosis in a 44‑year‑old male. The patient was referred to our hospital for further evaluation of multiple lobulated nodules in both lungs. As the multiple lung nodules were suspected to be metastatic, 18F‑ﬂuorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) was conducted, which revealed that the nodules had a mild uptake of 18F‑FCG. Amyloidosis was confirmed by conducting a percutaneous CT‑guided fine‑needle aspiration (FNA) biopsy in the left lung nodule. A literature review of previous studies on primary nodular parenchymal pulmonary amyloidosis from Medline (1970‑October 2011) and Embase (1989‑October 2011) was also included. Despite its rarity, primary nodular parenchymal pulmonary amyloidosis with a pattern of multiple nodules also forms part of the differential diagnosis of pulmonary metastases with high 18F‑FDG uptake on PET/CT.

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