The paediatric story of human papillomavirus (Review)

Mammas,Ioannis  N.; Sourvinos,George; Spandidos,Demetrios  A.

doi:10.3892/ol.2014.2226

The paediatric story of human papillomavirus (Review)

Authors:
- Ioannis N. Mammas
- George Sourvinos
- Demetrios A. Spandidos
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Affiliations: Department of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece
Published online on: June 4, 2014 https://doi.org/10.3892/ol.2014.2226
Pages: 502-506

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Abstract

Human papillomavirus (HPV) is composed of a particularly heterogeneous family of DNA viruses, which has gained much attention in recent years due to the discoveries of Professor Harald zur Hausen, who first identified a connection between HPV and cervical cancer. Professor Harald zur Hausen, the ‘Father of HPV Virology’, was the recipient of the 2008 Nobel Prize. HPV can be transmitted through physical contact via autoinoculation or fomites, sexual contact, as well as vertically from the HPV-positive mother to her newborn, causing subclinical or clinical infections. In infancy and childhood, HPV-associated clinical infections include skin warts, genital warts and juvenile recurrent respiratory papillomatosis, while cervical squamous intraepithelial lesions have also been reported among adolescent girls. To date, several research teams, worldwide, have extensively investigated HPV from the paediatric point of view. This primitive effort has been performed before the recent great expansion of paediatric HPV research due to the vaccination programmes against HPV, which were introduced into clinical practice in 2006. In this review article, we present a brief overview of paediatric HPV research after the first report in 1978 involving children in the research of HPV until the time point of this great expansion. In the future, it is expected that further unresolved issues will be addressed and clarified, as the paediatric story of HPV remains a challenging research target.

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1	zur Hausen H: Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2:342–350. 2002.
2	Mammas IN, Sourvinos G and Spandidos DA: Human papilloma virus (HPV) infection in children and adolescents. Eur J Pediatr. 168:267–273. 2009.
3	zur Hausen H: Papillomaviruses in the causation of human cancers - a brief historical account. Virology. 384:260–265. 2009.
4	Syrjänen S: Current concepts on human papillomavirus infections in children. APMIS. 118:494–509. 2010.
5	Pfister H and zur Hausen H: Seroepidemiological studies of human papilloma virus (HPV-1) infections. Int J Cancer. 21:161–165. 1978.
6	Lipourlis D: Hippokrates, Gynaikologia Maieutiki. Zitros Publications; Thessaloniki: 2001
7	Karaberopoulos D, Aristotelis P and Kouzis O: karkinos para tois arxaiois ellisin iatrois. 1902. Stamoulis Publications; Athens: 2004
8	Gasparini R and Panatto D: Cervical cancer: from Hippocrates through Rigoni-Stern to zur Hausen. Vaccine. 27(Suppl 1): A4–A5. 2009.
9	Rigoni-Stern DA: Fatti statistici relative alle malattie cancerose. Giorn Serv Progr Patol Terap. 2:507–517. 1842.
10	Mammas IN, Spandidos DA and George N: Papanicolaou (1883–1962): Fifty years after the death of a great doctor, scientist and humanitarian. J BUON. 17:180–184. 2012.
11	Papanicolaou GN and Traut HF: The diagnostic value of vaginal smears in carcinoma of the uterus. Am J Obst Gynecol. 42:193–206. 1941.
12	Papanicolaou GN: A new procedure for staining vaginal smears. Science. 95:438–439. 1942.
13	Strauss MJ, Shaw EW, Bunting H and Melnick JL: Crystalline virus-like particles from skin papillomas characterized by intranuclear inclusion bodies. Proc Soc Exp Biol Med. 72:46–50. 1949.
14	Crawford LV and Crawford EM: A comparative study of polyoma and papilloma viruses. Virology. 21:258–263. 1963.
15	Mammas IN, Sourvinos G, Zaravinos A and Spandidos DA: Vaccination against human papilloma virus (HPV): epidemiological evidence of HPV in non-genital cancers. Pathol Oncol Res. 17:103–119. 2011.
16	Payne J: On the contagious rise of common warts. Br J Dermatol. 3:1851891.
17	Costa J, Howley PM, Bowling MC, Howard R and Bauer WC: Presence of human papilloma viral antigens in juvenile multiple laryngeal papilloma. Am J Clin Pathol. 75:194–197. 1981.
18	Braun L, Kashima H, Eggleston J and Shah K: Demonstration of papillomavirus antigen in paraffin sections of laryngeal papillomas. Laryngoscope. 92:640–643. 1982.
19	Mounts P, Shah KV and Kashima H: Viral etiology of juvenile- and adult-onset squamous papilloma of the larynx. Proc Natl Acad Sci USA. 79:5425–5429. 1982.
20	Roman A and Fife K: Human papillomavirus DNA associated with foreskins of normal newborns. J Infect Dis. 153:855–861. 1986.
21	Rock B, Naghashfar Z, Barnett N, Buscema J, Woodruff JD and Shah K: Genital tract papillomavirus infection in children. Arch Dermatol. 122:1129–1132. 1986.
22	Vallejos H, Del Mistro A, Kleinhaus S, Braunstein JD, Halwer M and Koss LG: Characterization of human papilloma virus types in condylomata acuminata in children by in situ hybridization. Lab Invest. 56:611–615. 1987.
23	Steinberg BM: Papillomavirus. Effects upon mother and child. Ann N Y Acad Sci. 549:118–128. 1988.
24	Hanson RM, Glasson M, McCrossin I, Rogers M, Rose B and Thompson C: Anogenital warts in childhood. Child Abuse Negl. 13:225–233. 1989.
25	Sedlacek TV, Lindheim S, Eder C, Hasty L, Woodland M, Ludomirsky A and Rando RF: Mechanism for human papillomavirus transmission at birth. Am J Obstet Gynecol. 161:55–59. 1989.
26	Gibson PE, Gardner SD and Best SJ: Human papillomavirus types in anogenital warts of children. J Med Virol. 30:142–145. 1990.
27	Padel AF, Venning VA, Evans MF, Quantrill AM and Fleming KA: Human papillomaviruses in anogenital warts in children: typing by in situ hybridisation. BMJ. 300:1491–1494. 1990.
28	Jenison SA, Yu XP, Valentine JM, Koutsky LA, Christiansen AE, Beckmann AM and Galloway DA: Evidence of prevalent genital-type human papillomavirus infections in adults and children. J Infect Dis. 162:60–69. 1990.
29	Smith EM, Johnson SR, Jiang D, et al: The association between pregnancy and human papilloma virus prevalence. Cancer Detect Prev. 15:397–402. 1991.
30	Fredericks BD, Balkin A, Daniel HW, Schonrock J, Ward B and Frazer IH: Transmission of human papillomaviruses from mother to child. Aust N Z J Obstet Gynaecol. 33:30–32. 1993.
31	Pakarian F, Kaye JN, Cason J, et al: Cancer associated human papillomaviruses: perinatal transmission and persistence. Br J Obstet Gynaecol. 101:514–517. 1994.
32	Kaye JN, Cason J, Pakarian FB, et al: Viral load as a determinant for transmission of human papillomavirus type 16 from mother to child. J Med Virol. 44:415–421. 1994.
33	Cason J, Kaye JN, Jewers RJ, et al: Perinatal infection and persistence of human papillomavirus types 16 and 18 in infants. J Med Virol. 47:209–218. 1995.
34	Alberico S, Pinzano R, Comar M, Toffoletti F, Maso G, Ricci G and Guaschino S: Maternal-fetal transmission of human papillomavirus. Minerva Ginecol. 48:199–204. 1996.
35	Tseng CJ, Liang CC, Soong YK and Pao CC: Perinatal transmission of human papillomavirus in infants: relationship between infection rate and mode of delivery. Obstet Gynecol. 91:92–96. 1998.
36	Rice PS, Mant C, Cason J, Bible JM, Muir P, Kell B and Best JM: High prevalence of human papillomavirus type 16 infection among children. J Med Virol. 61:70–75. 2000.
37	Rintala MA, Grénman SE, Puranen MH, Isolauri E, Ekblad U, Kero PO and Syrjänen SM: Transmission of high-risk human papillomavirus (HPV) between parents and infant: a prospective study of HPV in families in Finland. J Clin Microbiol. 43:376–381. 2005.
38	Chen R, Sehr P, Waterboer T, Leivo I, Pawlita M, Vaheri A and Aaltonen LM: Presence of DNA of human papillomavirus 16 but no other types in tumor-free tonsillar tissue. J Clin Microbiol. 43:1408–1410. 2005.
39	Sisk J, Schweinfurth JM, Wang XT and Chong K: Presence of human papillomavirus DNA in tonsillectomy specimens. Laryngoscope. 116:1372–1374. 2006.
40	Mammas IN, Sourvinos G, Michael C and Spandidos DA: Human papilloma virus in hyperplastic tonsillar and adenoid tissues in children. Pediatr Infect Dis J. 25:1158–1162. 2006.
41	Sarkola M, Rintala M, Grénman S and Syrjänen S: Human papillomavirus DNA detected in breast milk. Pediatr Infect Dis J. 27:557–558. 2008.
42	Mammas I, Sourvinos G, Michael C and Spandidos DA: High-risk human papilloma viruses (HPVs) were not detected in the benign skin lesions of a small number of children. Acta Paediatr. 97:1669–1671. 2008.
43	Cazzaniga M, Gheit T, Casadio C, et al: Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis. Breast Cancer Res Treat. 114:599–605. 2009.
44	Mammas IN and Spandidos DA: No evidence of mother-to-infant transmission of human papilloma virus via human breast milk. Pediatr Infect Dis J. 29:932010.
45	Mammas IN, Sourvinos G, Vakonaki E, Giamarelou P, Michael C and Spandidos DA: Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis. Eur J Pediatr. 169:1017–1021. 2010.
46	Mammas IN, Sourvinos G and Spandidos DA: Maternal human papillomavirus (HPV) infection and its possible relationship with neonatal prematurity. Br J Biomed Sci. 67:222–224. 2010.
47	Mammas IN, Zaravinos A, Sourvinos G and Spandidos DA: Detection of human papillomavirus in bronchoalveolar lavage samples in immunocompetent children. Pediatr Infect Dis J. 30:384–386. 2011.
48	Yoshida K, Furumoto H, Abe A, et al: The possibility of vertical transmission of human papillomavirus through maternal milk. J Obstet Gynaecol. 31:503–506. 2011.
49	Mammas IN, Zaravinos A, Sourvinos G, Myriokefalitakis N, Theodoridou M and Spandidos DA: Can ‘high-risk’ human papillomaviruses (HPVs) be detected in human breast milk? Acta Paediatr. 100:705–707. 2011.
50	Mammas IN, Sourvinos G, Giamarelou P, Michael C and Spandidos DA: Human papillomavirus in the oral cavity of children and mode of delivery: a retrospective study. Int J STD AIDS. 23:185–188. 2012.
51	Cason J, Rice P and Best JM: Transmission of cervical cancer-associated human papilloma viruses from mother to child. Intervirology. 41:213–218. 1998.
52	Syrjänen S and Puranen M: Human papillomavirus infections in children: the potential role of maternal transmission. Crit Rev Oral Biol Med. 11:259–274. 2000.
53	Boggs W: Human papilloma virus present in hyperplastic tonsillar tissue in children. Reuters Health. December 28–2006, at www.reuters.comurisimplewww.reuters.com.
54	Mammas IN, Sourvinos G and Spandidos DA: The ‘Trojan horse’ oncogenic strategy of HPVs in childhood. Fut Virology. 8:801–808. 2013.
55	FUTURE II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med. 356:1915–1927. 2007.
56	Paavonen J, Naud P, Salmerón J, et al: Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet. 374:301–314. 2009.
57	Rafle AE: Challenges of implementing human papillomavirus (HPV) vaccination policy. BMJ. 335:375–377. 2007.
58	Maher F and Mammas I: HPV vaccination in younger pre-adolescents? 13–September. 2007, at www.bmj.com/content/335/7616/375?tab=responsesurisimplewww.bmj.com/content/335/7616/375?tab=responses.
59	Mammas I, Maher F, Theodoridou M and Spandidos DA: Human papilloma virus (HPV) vaccination in childhood: challenges and perspectives. Hippokratia. 15:299–303. 2011.
60	Mammas IN and Spandidos DA: Vaccination against human papillomavirus in childhood: the next rubella analogue? J BUON. 17:389–390. 2012.