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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2008 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 19 Issue 2

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Article

Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers

  • Authors:
    • Jirina Hofmanová
    • Alena Vaculová
    • Martina Hyzd'Alová
    • Alois Kozubík

  • View Affiliations / Copyright

    Affiliations: Laboratory of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, CZ-612 65 Brno, Czech Republic
  • Pages: 567-573
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/or.19.2.567
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Abstract

We compared the response of normal (FHC) and cancer (HT-29) human colon epithelial cells to the important apoptotic inducers TNF-α, anti-Fas antibody and TNF-related apoptosis inducing ligand (TRAIL). The two cell lines did not respond to TNF-α (15 ng/ml), expressed a limited sensitivity to anti-Fas antibody (200 ng/ml) and a different response to TRAIL (100 ng/ml). We studied apoptosis with regard to the changes at the receptor level (DR, DcR and FLIP) and at the level of mitochondria (Bid protein cleavage, Apo2.7 protein expression and caspase-9 activation). Two different approaches were used to sensitize the cells to TRAIL-induced apoptosis: inhibition of protein synthesis (cycloheximide, CHX) and inhibition of the pro-survival MEK/ERK pathway (U0126). While the two cell lines were markedly sensitized to all three TNF family members by CHX, a different degree of response (especially for TRAIL) was obtained when inhibition of the MEK/ERK pathway was achieved. TRAIL-induced apoptosis was significantly enhanced by U0126 co-treatment in the HT-29 cells, but not in the FHC cells. The most significant differences between the HT-29 and FHC cells co-treated with TRAIL and U0126 were demonstrated with regard to the involvement of the mitochondrial apoptotic pathway, suggesting its importance in the regulation of cell sensitivity to the TRAIL-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Hofmanová J, Vaculová A, Hyzd'Alová M and Kozubík A: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. Oncol Rep 19: 567-573, 2008.
APA
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., & Kozubík, A. (2008). Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. Oncology Reports, 19, 567-573. https://doi.org/10.3892/or.19.2.567
MLA
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., Kozubík, A."Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers". Oncology Reports 19.2 (2008): 567-573.
Chicago
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., Kozubík, A."Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers". Oncology Reports 19, no. 2 (2008): 567-573. https://doi.org/10.3892/or.19.2.567
Copy and paste a formatted citation
x
Spandidos Publications style
Hofmanová J, Vaculová A, Hyzd'Alová M and Kozubík A: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. Oncol Rep 19: 567-573, 2008.
APA
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., & Kozubík, A. (2008). Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. Oncology Reports, 19, 567-573. https://doi.org/10.3892/or.19.2.567
MLA
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., Kozubík, A."Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers". Oncology Reports 19.2 (2008): 567-573.
Chicago
Hofmanová, J., Vaculová, A., Hyzd'Alová, M., Kozubík, A."Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers". Oncology Reports 19, no. 2 (2008): 567-573. https://doi.org/10.3892/or.19.2.567
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