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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2009 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 22 Issue 1

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Article

Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells

  • Authors:
    • Jian Sun
    • Zhi-Ming Li
    • Zhe-Yu Hu
    • Zhao-Lei Zeng
    • Da-Jun Yang
    • Wen-Qi Jiang

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in Southern China, Guangzhou 510060, P.R. China
  • Pages: 193-198
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/or_00000424
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Abstract

We examined the effect of apogossypolone (ApoG2), a new derivative from gossypol on cell cycle regulation in U937 human leukemic monocyte lymphoma cells in vitro. ApoG2 decreased the viability of U937 cells by inducing G1 arrest followed by apoptosis in a dose-dependent manner. The G0/G1 phase of the cell cycle is regulated by cyclin-dependent kinases (Cdk), cyclins and cyclin-dependent kinase inhibitors (Cdki). We show by western blot analysis, that the ApoG2-induced G1 arrest was mediated through the increased expression of Cdki proteins (p21cip1/waf1) with a simultaneous decrease in cdk2, cdk4, cyclin D1 and cyclin E expression. The induction of apoptosis after treatment with ApoG2 for 12, 24 and 48 h was demonstrated by flow cytometry analysis. ApoG2 also induced cytochrome c release and activation of caspase-3. To our knowledge, this is the first time that ApoG2 has been reported to potently inhibit the proliferation of human monocytic lymphoma U937 cells through G1 arrest. These findings suggest that ApoG2 may be a potential chemotherapeutic agent for the treatment of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sun J, Li Z, Hu Z, Zeng Z, Yang D and Jiang W: Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. Oncol Rep 22: 193-198, 2009.
APA
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., & Jiang, W. (2009). Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. Oncology Reports, 22, 193-198. https://doi.org/10.3892/or_00000424
MLA
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., Jiang, W."Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells". Oncology Reports 22.1 (2009): 193-198.
Chicago
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., Jiang, W."Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells". Oncology Reports 22, no. 1 (2009): 193-198. https://doi.org/10.3892/or_00000424
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Li Z, Hu Z, Zeng Z, Yang D and Jiang W: Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. Oncol Rep 22: 193-198, 2009.
APA
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., & Jiang, W. (2009). Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. Oncology Reports, 22, 193-198. https://doi.org/10.3892/or_00000424
MLA
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., Jiang, W."Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells". Oncology Reports 22.1 (2009): 193-198.
Chicago
Sun, J., Li, Z., Hu, Z., Zeng, Z., Yang, D., Jiang, W."Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells". Oncology Reports 22, no. 1 (2009): 193-198. https://doi.org/10.3892/or_00000424
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