Investigation of the clinicopathological features of fallopian tube malignancy

Yokoyama,Yoshihito; Futagami,Masayuki; Fujimoto,Toshio; Terada,Yukihiro; Takatori,Eriko; Sugiyama,Toru; Otsuki,Takeo; Yaegashi,Nobuo; Kojimahara,Takanobu; Kurachi,Hirohisa; Nishiyama,Hiroshi; Fujimori,Keiya; Tase,Toru; Mizunuma,Hideki

doi:10.3892/or.2013.2439

Investigation of the clinicopathological features of fallopian tube malignancy

Authors:
- Yoshihito Yokoyama
- Masayuki Futagami
- Toshio Fujimoto
- Yukihiro Terada
- Eriko Takatori
- Toru Sugiyama
- Takeo Otsuki
- Nobuo Yaegashi
- Takanobu Kojimahara
- Hirohisa Kurachi
- Hiroshi Nishiyama
- Keiya Fujimori
- Toru Tase
- Hideki Mizunuma
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Affiliations: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan, Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010-8543, Japan, Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka 020-8505, Japan, Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba-ku, Sendai 980‑8574, Japan, Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata 990‑9585, Japan, Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Gynecology, Miyagi Cancer Center, Natori 981-1293, Japan
Published online on: April 30, 2013 https://doi.org/10.3892/or.2013.2439
Pages: 79-84

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Abstract

The present study investigated the clinicopathological features of fallopian tube malignancy (FTM) and elucidated the biological behavior of this disorder. Data were compiled concerning FTM from 68 patients from 7 institutes. The patients included 60 cases with fallopian tube carcinoma and 8 cases with fallopian tube carcinosarcoma. The clinical stage was stage III or higher in 72% of the cases. A complete response or partial response was achieved in 56 and 10 of the 68 patients with FTM, respectively, indicating a response rate of 97.1%. The median observation period for FTM was 41 months (3 to 126 months). Three of the 19 patients with stage I/II disease (16%) and 31 of the 49 patients with stage III/IV disease (63%) experienced recurrence, with a median progression-free survival of 17.5 months, and a 3-year overall survival of 77.2%. Regarding the site of recurrence, local intraperitoneal recurrence (26.2%) and solitary recurrences in lymph nodes (19.0%) and in the liver (16.7%) were relatively frequent. Secondary debulking surgery (SDS) was performed in 15 patients (44%) out of the 34 recurrent FTMs. Conversely, recurrence was associated with ascites (carcinomatous peritonitis) in 4 of the 34 recurrent patients, but all 4 patients died. The median survival period after recurrence was 28 months: 7.5 and 30 months with and without ascites, respectively (P<0.001). A univariate analysis showed that prognosis was significantly correlated only with whether SDS could be performed. These results suggest that since FTM frequently results in solitary recurrence, aggressive recurrence treatment including SDS could improve prognosis.

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