Balbo S, Upadhyaya P, Villalta PW, Qian X and Kassie F: DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chem Res Toxicol. Mar 12–2013.(Epub ahead of print).

Akopyan G and Bonavida B: Understanding tobacco smoke carcinogen NNK and lung tumorigenesis (Review). Int J Oncol. 29:745–752. 2006.PubMed/NCBI

Chen RJ, Chang LW, Lin P and Wang YJ: Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview. J Oncol. 2011:6549312011.PubMed/NCBI

Belinsky SA, Devereux TR, Foley JF, Maronpot RR and Anderson MW: Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res. 52:3164–3173. 1992.PubMed/NCBI

Imaida K, Yokohira M and Kuno T: Detection of carcinogenic and modifying potentials by test compounds using a mouse lung carcinogenesis bioassay (Review). J Toxicol Pathol. 20:117–123. 2007. View Article : Google Scholar

Takeuchi H, Saoo K, Matsuda Y, et al: 8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Mol Med Rep. 2:585–588. 2009.

Takeuchi H, Saoo K, Matsuda Y, et al: Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice. Cancer Lett. 234:232–238. 2006. View Article : Google Scholar : PubMed/NCBI

Takeuchi H, Saoo K, Yokohira M, et al: Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Cancer Res. 63:7581–7583. 2003.

Yokohira M, Takeuchi H, Saoo K, et al: Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. Exp Toxicol Pathol. 60:469–473. 2008. View Article : Google Scholar : PubMed/NCBI

Kuno T, Yokohira M, Matsuda Y, et al: Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice. Oncol Rep. 20:767–772. 2008.PubMed/NCBI

Matsuda Y, Saoo K, Hosokawa K, et al: Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice. Cancer Lett. 246:41–46. 2007. View Article : Google Scholar : PubMed/NCBI

Yamakawa K, Kuno T, Hashimoto N, et al: Molecular analysis of carcinogen-induced rodent lung tumors: Involvement of microRNA expression and Kras or Egfr mutations. Mol Med Rep. 3:141–147. 2010.PubMed/NCBI

Yokohira M, Hashimoto N, Yamakawa K, Saoo K, Kuno T and Imaida K: Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer. Exp Toxicol Pathol. 63:181–185. 2011. View Article : Google Scholar

Yokohira M, Hashimoto N, Yamakawa K, et al: Lack of modifying effects of intratracheal instillation of quartz or dextran sulfate sodium (DSS) in drinking water on lung tumor development initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. J Toxicol Pathol. 22:179–185. 2009. View Article : Google Scholar : PubMed/NCBI

Miyazaki M, Yamazaki H, Takeuchi H, et al: Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. Carcinogenesis. 26:1947–1955. 2005. View Article : Google Scholar : PubMed/NCBI

Igarashi M, Watanabe M, Yoshida M, et al: Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. J Toxicol Sci. 34:163–174. 2009.

Morita T: A statistical study of lung cancer in the annual of pathological autopsy cases in Japan, from 1958 to 1997, with reference to time trends of lung cancer in the world. Jpn J Cancer Res. 93:15–23. 2002. View Article : Google Scholar : PubMed/NCBI

Sobue T, Ajiki W, Tsukuma H, Oshima A, Hanai A and Fujimoto I: Trends of lung cancer incidence by histologic type: a population-based study in Osaka, Japan. Jpn J Cancer Res. 90:6–15. 1999. View Article : Google Scholar : PubMed/NCBI

Zang EA and Wynder EL: Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst. 88:183–192. 1996. View Article : Google Scholar : PubMed/NCBI

Belani CP, Marts S, Schiller J and Socinski MA: Women and lung cancer: epidemiology, tumor biology, and emerging trends in clinical research. Lung Cancer. 55:15–23. 2007. View Article : Google Scholar : PubMed/NCBI

Nishio M, Ohyanagi F, Horiike A, et al: Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients. Br J Cancer. 92:1877–1880. 2005. View Article : Google Scholar : PubMed/NCBI

Mohr U: International Classification of Rodent Tumors: The Mouse. 1st edition. Springer-Verlag; Berlin: 2001, View Article : Google Scholar

de Kretser DM: The Testis. Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV: 3. 2nd edition. Cambridge University Press; Cambridge: pp. 76–90. 1984

Baird DT: The Ovary. Reproduction in Mammals: Hormonal Control of Reproduction. Austin CR and Short RV: 3. 2nd edition. Cambridge University Press; Cambridge: pp. 91–114. 1984, View Article : Google Scholar

Pelletier G, Luu-The V, Li S and Labrie F: Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization. Cell Tissue Res. 320:393–398. 2005.

Matsuura S and Suzuki K: Morphological changes in the submandibular glands and in the X zone of the adrenal gland following ovariectomy in mice. Cell Tissue Res. 246:549–556. 1986. View Article : Google Scholar : PubMed/NCBI

Kamei Y, Suzuki M, Miyazaki H, et al: Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat. J Nutr Sci Vitaminol. 51:110–117. 2005. View Article : Google Scholar : PubMed/NCBI

Wu J, Wang X, Chiba H, et al: Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism. 53:942–948. 2004. View Article : Google Scholar : PubMed/NCBI

Yamaguchi M, Katoh S, Morimoto C, et al: The hormonal responses of lipoprotein lipase activity and lipolysis in adipose tissue differ depending on the stage of the estrous cycle in female rats. Int J Obes Relat Metab Disord. 26:610–617. 2002. View Article : Google Scholar : PubMed/NCBI

Duffel MW, Graham JM and Ziegler DM: Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones. Mol Pharmacol. 19:134–139. 1981.PubMed/NCBI

Kamataki T, Fujita KI, Nakayama K, Yamazaki Y, Miyamoto M and Ariyoshi N: Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. Drug Metab Rev. 34:667–676. 2002. View Article : Google Scholar : PubMed/NCBI

Wiener D, Doerge DR, Fang JL, Upadhyaya P and Lazarus P: Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug Metab Dispos. 32:72–79. 2004.

Benowitz NL, Lessov-Schlaggar CN, Swan GE and Jacob P III: Female sex and oral contraceptive use accelerate nicotine metabolism. Clinl Pharmacol Ther. 79:480–488. 2006. View Article : Google Scholar : PubMed/NCBI

Miners JO, Grgurinovich N, Whitehead AG, Robson RA and Birkett DJ: Influence of gender and oral contraceptive steroids on the metabolism of salicytic acid and acetylsalicylic acid. Br J Clin Pharmacol. 22:135–142. 1986. View Article : Google Scholar : PubMed/NCBI

Mitchell MC, Hanew T, Meredith CG and Schenker S: Effects of oral contraceptive steroids on acetaminophen metabolism and elimination. Clin Pharmacol Ther. 34:48–53. 1983. View Article : Google Scholar : PubMed/NCBI

Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP and Smith RB: Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics. Clin Pharmacol Ther. 36:683–690. 1984. View Article : Google Scholar : PubMed/NCBI

Balogh A, Klinger G, Henschel L, Börner A, Vollanth R and Kuhnz W: Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur J Clin Pharmacol. 48:161–166. 1995. View Article : Google Scholar : PubMed/NCBI

Laine K, Tybring G and Bertilsson L: No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects. Clin Pharmacol Ther. 68:151–159. 2000. View Article : Google Scholar

Slayter KL, Ludwig EA, Lew KH, Middleton E Jr, Ferry JJ and Jusko WJ: Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 59:312–321. 1996. View Article : Google Scholar : PubMed/NCBI

Mikkonen L, Pihlajamaa P, Sahu B, Zhang FP and Jänne OA: Androgen receptor and androgen-dependent gene expression in lung. Mol Cell Endocrinol. 317:14–24. 2010. View Article : Google Scholar : PubMed/NCBI