Open Access

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway

  • Authors:
    • Brandon M. Schickling
    • Sarah K. England
    • Nukhet Aykin-Burns
    • Lyse A. Norian
    • Kimberly K. Leslie
    • Victoria P. Frieden-Korovkina
  • View Affiliations

  • Published online on: November 24, 2014     https://doi.org/10.3892/or.2014.3617
  • Pages:533-538
  • Copyright: © Schickling et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxin (IbTX), an inhibitor of BKCa channels, differentially modulated the in vitro tumorigenic activities of hormone-independent breast cancer cells. Specifically, in HER-2/neu-overexpressing UACC893 cells and triple‑negative MDA-MB-231 cells, IbTX selectively attenuated anchorage-independent growth with concomitant downregulation of β-catenin as well as total and phosphorylated Akt and HER-2/neu. By contrast, HER-2/neu-overexpressing SK-BR-3 cells were insensitive to IbTX. Molecular analyses showed an absence of β-catenin and a dose-dependent upregulation of total and phosphorylated Akt and HER-2/neu in these cells. Taken together, these studies identify β-catenin as a putative modulator of the inhibitory actions of IbTX in sensitive breast cancer cells.

Related Articles

Journal Cover

February 2015
Volume 33 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Schickling, B.M., England, S.K., Aykin-Burns, N., Norian, L.A., Leslie, K.K., & Frieden-Korovkina, V.P. (2015). BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncology Reports, 33, 533-538. https://doi.org/10.3892/or.2014.3617
MLA
Schickling, B. M., England, S. K., Aykin-Burns, N., Norian, L. A., Leslie, K. K., Frieden-Korovkina, V. P."BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway". Oncology Reports 33.2 (2015): 533-538.
Chicago
Schickling, B. M., England, S. K., Aykin-Burns, N., Norian, L. A., Leslie, K. K., Frieden-Korovkina, V. P."BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway". Oncology Reports 33, no. 2 (2015): 533-538. https://doi.org/10.3892/or.2014.3617