Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer

  • Authors:
    • Guangming Jin
    • Mingji Jin
    • Zhehu Jin
    • Zhonggao Gao
    • Xuezhe Yin
  • View Affiliations

  • Published online on: June 8, 2016     https://doi.org/10.3892/or.2016.4863
  • Pages: 871-876
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was mainly to assess the advantage of docetaxel-loaded PEG-albumin nanoparticles (PEG-DANPs) against non-small cell lung cancer (NSCLC) compared with the commercial product of docetaxel (Aisu®) and docetaxel-albumin nanoparticles (DANPs). We made systematic assessments on these three drugs against NSCLC both in vitro and in vivo. Based on our experiments, PEG-DANPs showed a dose- and time-dependent efficacy in the in vitro cytotoxicity studies; the tumors growth and the metastases in the livers of NSCLC-bearing nude mice in vivo were reduced dmarkedly by PEG-DANPs, and the PEG-DANP-treated mice had a minimum of weight loss; furthermore, the mice which were treated with PEG-DANPs can survive longer than the other groups. In conclusion, the PEG-DANPs have the lowest side-effects, and the highest antitumor and metastases activity of the three drugs, and it may provide an alternative to patients with NSCLC.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 36 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jin G, Jin M, Jin Z, Gao Z and Yin X: Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncol Rep 36: 871-876, 2016
APA
Jin, G., Jin, M., Jin, Z., Gao, Z., & Yin, X. (2016). Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncology Reports, 36, 871-876. https://doi.org/10.3892/or.2016.4863
MLA
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36.2 (2016): 871-876.
Chicago
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36, no. 2 (2016): 871-876. https://doi.org/10.3892/or.2016.4863