miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3 Retraction in /10.3892/or.2021.8193

Liu,Shu; Hu,Chunmei; Wang,Yingxue; Shi,Guang; Li,Yarong; Wu,Huang

doi:10.3892/or.2016.4999

miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3

Retraction in: /10.3892/or.2021.8193

Authors:
- Shu Liu
- Chunmei Hu
- Yingxue Wang
- Guang Shi
- Yarong Li
- Huang Wu
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Affiliations: Department of Ophthalmology, The Second Hospital of Jilin University, Nanguan, Changchun, Jilin 130041, P.R. China, Department of Tumor and Hematology, The Second Hospital of Jilin University, Nanguan, Changchun, Jilin 130041, P.R. China, Department of Electrical Diagnosis, The Second Hospital of Jilin University, Nanguan, Changchun, Jilin 130041, P.R. China
Published online on: August 3, 2016 https://doi.org/10.3892/or.2016.4999
Pages: 2398-2404

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Abstract

A growing body of evidence suggests that microRNA-124 (miR-124) functions as tumor-suppressor, and involves in tumor initiation, development and metastasis in major classes of human cancers; however, the biological role and underlying molecular mechanism of miR-124 in retinoblastoma (RB) remain unknown. Therefore, we investigated the biological activity and underlying molecular mechanism of miR-124 in human retinoblastoma. In the present study, our results demonstrated the downregulation of miR-124 in RB tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro. Furthermore, signal transducer and activator of transcription 3 (STAT3) was identified as a new target of miR-124, and overexpression of miR-124 decreased STAT3 expression on mRNA level and protein level in human RB cells. We also found that STAT3 mRNA expression was upregulated and inversely correlated with miR-124 expression in the RB tissues (r=-0.683; P<0.001). Restoration of the expression of STAT3 rescues the effects induced by miR-124 in RB cells. The findings of the present study suggested that miR-124 functioned as tumor suppressor in RB, at least in part, by targeting STAT3, and that it could serve as a potential candidate for RB therapeutics.

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