MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma

  • Authors:
    • Yun Yang
    • Jin Zhang
    • Tian Xia
    • Gaiyun Li
    • Tao Tian
    • Mengchao Wang
    • Ruoyu Wang
    • Linghao Zhao
    • Yuan Yang
    • Ke Lan
    • Weiping Zhou
  • View Affiliations

  • Published online on: September 23, 2016     https://doi.org/10.3892/or.2016.5129
  • Pages: 2553-2562
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hypoxia drives cancer to become more aggressive, particularly angiogenesis, and the corresponding mechanisms still need to be further investigated. In hepatocellular carcinoma (HCC), the master hypoxia-induced microRNA (miRNA) miR-210 is upregulated in HCC and participates in HCC progression, but its roles in hypoxia-induced HCC angiogenesis are still unknown. Moreover, the correlation between miR-210 expression and HCC clinical progression also needs elucidation. In the present study, we found that miR-210 expression was progressively increased from normal liver and adjacent non-tumor tissues, to incipient and advanced tumor tissues. In HCC patients, high miR-210 expression was significantly correlated with poor prognosis, both tumor-free survival and overall survival. Moreover, miR-210 expression in HCC was significantly positively correlated with microvascular density. Both in vitro and in vivo studies determined that miR-210 promoted HCC angiogenesis, and the corresponding mechanism was identified to be the direct targeting and inhibition of fibroblast growth factor receptor-like 1 (FGFRL1) expression. Thus, we suggest a new prognosis predictor for HCC patients, and determined the roles of hypoxic miR-210 in HCC angiogenesis.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K, Lan K, et al: MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncol Rep 36: 2553-2562, 2016
APA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M. ... Zhou, W. (2016). MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma. Oncology Reports, 36, 2553-2562. https://doi.org/10.3892/or.2016.5129
MLA
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36.5 (2016): 2553-2562.
Chicago
Yang, Y., Zhang, J., Xia, T., Li, G., Tian, T., Wang, M., Wang, R., Zhao, L., Yang, Y., Lan, K., Zhou, W."MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma". Oncology Reports 36, no. 5 (2016): 2553-2562. https://doi.org/10.3892/or.2016.5129