Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer

  • Authors:
    • Heyan Zhao
    • Jianhua Xue
    • Junhua Liu
    • Yifei Liu
    • Yinan Cheng
  • View Affiliations

  • Published online on: September 12, 2016     https://doi.org/10.3892/or.2016.5081
  • Pages: 2814-2822
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the effect of metastasis suppressor 1 (MTSS1) on the proliferation, migration and invasion of human H1299 non-small cell lung cancer cells and its clinical significance in non‑small cell lung cancer. The target gene MTSS1-overexpressing lentivirus (LV-MTSS1) was transfected into H1299 cells and expression of MTSS1 was detected at the mRNA and protein levels. Cell Counting Kit-8, wound healing and Transwell assays revealed that the migration and invasion activities were significantly suppressed by MTSS1, but that it had no effect on cell proliferation. In addition, MTSS1 expression in tissue microarrays including samples from 223 cases of non-small cell lung cancer was tested by immunohistochemistry to explore the correlation between MTSS1 and clinicopathological characteristics and prognosis. MTSS1 suppressed H1299 cell migration and invasion, and its expression level can be used as a new independent factor for determining the prognosis of non-small cell lung cancer.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Xue J, Liu J, Liu Y and Cheng Y: Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer. Oncol Rep 36: 2814-2822, 2016
APA
Zhao, H., Xue, J., Liu, J., Liu, Y., & Cheng, Y. (2016). Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer. Oncology Reports, 36, 2814-2822. https://doi.org/10.3892/or.2016.5081
MLA
Zhao, H., Xue, J., Liu, J., Liu, Y., Cheng, Y."Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer". Oncology Reports 36.5 (2016): 2814-2822.
Chicago
Zhao, H., Xue, J., Liu, J., Liu, Y., Cheng, Y."Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer". Oncology Reports 36, no. 5 (2016): 2814-2822. https://doi.org/10.3892/or.2016.5081