FoxO3a mediates glioma cell invasion by regulating MMP9 expression

  • Authors:
    • Ke Xu
    • Hua Pei
    • Zhenhao Zhang
    • Sufang Dong
    • Rui-Jia Fu
    • Wen-Ming Wang
    • Huamin Wang
  • View Affiliations

  • Published online on: September 12, 2016     https://doi.org/10.3892/or.2016.5087
  • Pages: 3044-3050
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The role of FoxO3a in glioma progression is poorly defined. Herein, we show that silencing FoxO3a in U251 cells leads to decreased invasive migration and proliferation, while ectopic expression of FoxO3a in U87 cells with weak endogenous FoxO3a protein levels enhances invasion and proliferation. To further investigate the mechanism by which FoxO3a promotes invasion, we detected key members of the matrix metalloproteinases (MMPs) that are associated with invasion. Our findings showed that, among these MMP members, only FoxO3a induced MMP9 expression, and MMP9 overexpression reversed the effect that silencing FoxO3a had on the attenuation of cell invasion. Taken together, these data link FoxO3a to the promotion of metastasis in glioma cells.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu K, Pei H, Zhang Z, Dong S, Fu R, Wang W and Wang H: FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncol Rep 36: 3044-3050, 2016
APA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., & Wang, H. (2016). FoxO3a mediates glioma cell invasion by regulating MMP9 expression. Oncology Reports, 36, 3044-3050. https://doi.org/10.3892/or.2016.5087
MLA
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36.5 (2016): 3044-3050.
Chicago
Xu, K., Pei, H., Zhang, Z., Dong, S., Fu, R., Wang, W., Wang, H."FoxO3a mediates glioma cell invasion by regulating MMP9 expression". Oncology Reports 36, no. 5 (2016): 3044-3050. https://doi.org/10.3892/or.2016.5087