Open Access

Long non-coding RNAs act as regulators of cell autophagy in diseases (Review)

  • Authors:
    • Zhijie Xu
    • Yuanliang Yan
    • Long Qian
    • Zhicheng Gong
  • View Affiliations

  • Published online on: February 1, 2017     https://doi.org/10.3892/or.2017.5416
  • Pages: 1359-1366
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Identification of long non-coding RNAs (lncRNAs) has provided a substantial increase in our understanding of the non-coding transcriptome. Studies have revealed a crucial function of lncRNAs in the modulation of cell autophagy in vitro and in vivo, further contributing to the hallmarks of disease phenotypes. These findings have profoundly altered our understanding of disease pathobiology, and may lead to the emergence of new biological concepts underlying autophagy-associated diseases, such as the carcinomas. Studies on the molecular mechanism of the lncRNA-autophagy axis may offer additional avenues for therapeutic intervention and biomarker assessment. In this review, we discuss recent findings on the multiple molecular roles of regulatory lncRNAs in the signaling pathways of cell autophagy. The emerging knowledge in this rapidly advancing field will offer novel insights into human diseases, especially cancers.
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March-2017
Volume 37 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Z, Yan Y, Qian L and Gong Z: Long non-coding RNAs act as regulators of cell autophagy in diseases (Review). Oncol Rep 37: 1359-1366, 2017
APA
Xu, Z., Yan, Y., Qian, L., & Gong, Z. (2017). Long non-coding RNAs act as regulators of cell autophagy in diseases (Review). Oncology Reports, 37, 1359-1366. https://doi.org/10.3892/or.2017.5416
MLA
Xu, Z., Yan, Y., Qian, L., Gong, Z."Long non-coding RNAs act as regulators of cell autophagy in diseases (Review)". Oncology Reports 37.3 (2017): 1359-1366.
Chicago
Xu, Z., Yan, Y., Qian, L., Gong, Z."Long non-coding RNAs act as regulators of cell autophagy in diseases (Review)". Oncology Reports 37, no. 3 (2017): 1359-1366. https://doi.org/10.3892/or.2017.5416