Open Access

Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma

  • Authors:
    • Eva Sipos
    • Kata Hegyi
    • Andrea Treszl
    • Zita Steiber
    • Gabor Mehes
    • Nikoletta Dobos
    • Klara Fodor
    • Gabor Olah
    • Lorant Szekvolgyi
    • Andrew V. Schally
    • Gabor Halmos
  • View Affiliations

  • Published online on: March 8, 2017     https://doi.org/10.3892/or.2017.5496
  • Pages: 1927-1934
  • Copyright: © Sipos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Uveal melanoma (UM) is the most common primary intraocular malignancy with a very poor prognosis. The most frequent chromosome aberration in UM is the monosomy of chromosome 3. Previously, we demonstrated that ~50% of UMs express type-I receptor for luteinizing hormone‑releasing hormone (LH-RH-R). The gene encoding LH-RH-R is located in chromosome 4 (location: 4q21.2); however, the occurrence of numerical aberrations of chromosome 4 have never been studied in UM. In the present study, we investigated the abnormalities of chromosome 3 and 4, and the possible correlation between them, as well as with LH-RH-R expression. Forty-six specimens of UM were obtained after enucleation. Numerical aberrations of chromosome 3 and 4 were studied by fluorescence in situ hybridization (FISH). Chromosome 4 was detected in normal biparental disomy only in 14 (30%) samples; however, 32 cases (70%) showed more than 2 signals/nucleus. Monosomy of chromosome 3 could be found in 16 (35%) samples. In 6 specimens (13%), more than 2 copies of chromosome 3 were found, while normal biparental disomy was detected in 24 (52%) samples. Statistical analysis indicated a statistically significant (p<0.05) correlation between the copy number of chromosome 3 and 4. Moreover, moderate difference was revealed in the survival rate of the UM patients with various pathological profiles. No correlation was found between chromosome aberrations and LH-RH-R expression. Our results clearly demonstrate abnormalities in chromosome 3 and 4 and the incidence of the monosomy of chromosome 3 in human UM. In summary, our results provide new incite concerning the genetic background of this tumor. Our findings could contribute to a more precise determination of the prognosis of human UM and to the development of new therapeutic approaches to this malignancy.
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April-2017
Volume 37 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sipos E, Hegyi K, Treszl A, Steiber Z, Mehes G, Dobos N, Fodor K, Olah G, Szekvolgyi L, Schally AV, Schally AV, et al: Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma. Oncol Rep 37: 1927-1934, 2017
APA
Sipos, E., Hegyi, K., Treszl, A., Steiber, Z., Mehes, G., Dobos, N. ... Halmos, G. (2017). Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma. Oncology Reports, 37, 1927-1934. https://doi.org/10.3892/or.2017.5496
MLA
Sipos, E., Hegyi, K., Treszl, A., Steiber, Z., Mehes, G., Dobos, N., Fodor, K., Olah, G., Szekvolgyi, L., Schally, A. V., Halmos, G."Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma". Oncology Reports 37.4 (2017): 1927-1934.
Chicago
Sipos, E., Hegyi, K., Treszl, A., Steiber, Z., Mehes, G., Dobos, N., Fodor, K., Olah, G., Szekvolgyi, L., Schally, A. V., Halmos, G."Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma". Oncology Reports 37, no. 4 (2017): 1927-1934. https://doi.org/10.3892/or.2017.5496