Open Access

Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer

  • Authors:
    • Dong-Xu He
    • Xiao-Li Wu
    • Chun-Xiao Lu
    • Xiao-Ting Gu
    • Guang-Yuan Zhang
    • Xin Ma
    • De-Quan Liu
  • View Affiliations

  • Published online on: October 12, 2017     https://doi.org/10.3892/or.2017.6033
  • Pages:3392-3402
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The expression of estrogen receptor α (ER) in breast cancers may be indicative of a favorable prognosis and most of these cancers respond to anti-estrogens or aromatase inhibitors. However, ER-positive (ER+) breast cancers receiving anti-hormone and/or chemotherapy sometimes lose their ER expression, which leads to the evolution of the disease to higher aggressiveness and drug resistance. In the present study, an ER-modified signature (EMS) was developed from the expression profile of a chemoresistant MCF-7 breast cancer cell line that lost ER expression during long-term treatment with a chemotherapeutic agent. The EMS could discriminate the ER-negative (ER-) breast cancer cells from the ER+ ones, which included seven pathways essential for the ER- cell development. Furthermore, the EMS indicated a more malignant subgroup of the ER- cells by discriminating the chemoresistant ER- cells from the chemosensitive ones. In addition, the classified chemoresistant ER- patients demonstrated worse prognosis. In conclusion, we developed a new method to discriminate subgroups of ER- breast cancer cells.

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Journal Cover

December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

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APA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., & Liu, D. (2017). Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer. Oncology Reports, 38, 3392-3402. https://doi.org/10.3892/or.2017.6033
MLA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38.6 (2017): 3392-3402.
Chicago
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38, no. 6 (2017): 3392-3402. https://doi.org/10.3892/or.2017.6033