Baicalin inhibits the metastasis of highly aggressive breast cancer cells by reversing epithelial-to-mesenchymal transition by targeting β-catenin signaling

  • Authors:
    • Tao Zhou
    • Aijie Zhang
    • Ge Kuang
    • Xia Gong
    • Rong Jiang
    • Dan Lin
    • Jie Li
    • Hongzhong Li
    • Xiang Zhang
    • Jingyuan Wan
    • Hongyuan Li
  • View Affiliations

  • Published online on: September 28, 2017     https://doi.org/10.3892/or.2017.6011
  • Pages:3599-3607
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Abstract

Metastasis is the main cause of death in breast cancer patients, which is due partly to the lack of effective treatment. Baicalin, a flavonoid compound isolated from the roots of Scutellaria lateriflora Georgi (Huang Qin), has recently been confirmed as an effective agent for the treatment of a variety of cancers. Yet, the effects and underlying molecular mechanisms of baicalin in regards to the metastasis of breast cancer remain unclear. In the present study, we found that baicalin had the potential to suppress the migration and invasion of highly aggressive breast cancer cells in a dose-dependent manner but had no impact on the viability of these cancer cells. Additionally, baicalin reversed the epithelial-to-mesenchymal transition (EMT) process, as evaluated by EMT markers in breast cancer cell lines with a change from a mesenchymal feature to an epithelial type. At the same time, the expression of β-catenin mRNA and protein was dose-dependently downregulated by baicalin in highly invasive breast cancer cell lines, and overexpression of β-catenin by adenoviruses abolished these beneficial effects of baicalin in regards to the migration and invasion, and EMT of breast cancer cells. Furthermore, using a xenograft mouse model, baicalin markedly reduced liver and lung metastasis of breast cancer, inhibited expression of β-catenin, and degraded the EMT molecules vimentin and Slug in the orthotopic tumor tissues. Taken together, all these results indicate that baicalin effectively suppresses the metastasis of breast cancer by reversing EMT, which may be mediated by downregulation of β-catentin expression.

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December 2017
Volume 38 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Zhou, T., Zhang, A., Kuang, G., Gong, X., Jiang, R., Lin, D. ... Li, H. (2017). Baicalin inhibits the metastasis of highly aggressive breast cancer cells by reversing epithelial-to-mesenchymal transition by targeting β-catenin signaling. Oncology Reports, 38, 3599-3607. https://doi.org/10.3892/or.2017.6011
MLA
Zhou, T., Zhang, A., Kuang, G., Gong, X., Jiang, R., Lin, D., Li, J., Li, H., Zhang, X., Wan, J., Li, H."Baicalin inhibits the metastasis of highly aggressive breast cancer cells by reversing epithelial-to-mesenchymal transition by targeting β-catenin signaling". Oncology Reports 38.6 (2017): 3599-3607.
Chicago
Zhou, T., Zhang, A., Kuang, G., Gong, X., Jiang, R., Lin, D., Li, J., Li, H., Zhang, X., Wan, J., Li, H."Baicalin inhibits the metastasis of highly aggressive breast cancer cells by reversing epithelial-to-mesenchymal transition by targeting β-catenin signaling". Oncology Reports 38, no. 6 (2017): 3599-3607. https://doi.org/10.3892/or.2017.6011