Open Access

Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer

  • Authors:
    • Qingde Wa
    • Li Li
    • Hongcheng Lin
    • Xinsheng Peng
    • Dong Ren
    • Yan Huang
    • Peiheng He
    • Shuai Huang
  • View Affiliations

  • Published online on: November 13, 2017     https://doi.org/10.3892/or.2017.6096
  • Pages:81-90
  • Copyright: © Wa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Constitutive activation of TGF‑β signaling pathway is a well-documented mechanism responsible for the bone metastasis of prostate cancer (PCa). MicroRNAs (miRNAs) have been reported to be crucial for the activation of TGF‑β signaling via targeting downstream components of TGF‑β signaling pathway. Here, we report that miR‑19a‑3p is downregulated in bone metastatic PCa tissues and cells. Upregulation of miR‑19a‑3p suppresses invasion, migration in vitro and inhibits bone metastasis in vivo in PCa cells. Conversely, silencing miR‑19a‑3p yields the opposite effect. Our results further demonstrate that miR‑19a‑3p inhibits invasion and migration abilities of PCa cells via targeting downstream effectors of TGF‑β signaling, SMAD2 and SMAD4, resulting in the inactivation of TGF‑β signaling. Therefore, our results uncover a novel mechanistic understanding of miR‑19a‑3p-induced suppressive role in bone metastasis of PCa, which will facilitate the development of effective cancer therapy methods against PCa.

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Journal Cover

January 2018
Volume 39 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

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APA
Wa, Q., Li, L., Lin, H., Peng, X., Ren, D., Huang, Y. ... Huang, S. (2018). Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer. Oncology Reports, 39, 81-90. https://doi.org/10.3892/or.2017.6096
MLA
Wa, Q., Li, L., Lin, H., Peng, X., Ren, D., Huang, Y., He, P., Huang, S."Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer". Oncology Reports 39.1 (2018): 81-90.
Chicago
Wa, Q., Li, L., Lin, H., Peng, X., Ren, D., Huang, Y., He, P., Huang, S."Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer". Oncology Reports 39, no. 1 (2018): 81-90. https://doi.org/10.3892/or.2017.6096