miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer

Liu,Zhuo; Yu,Miao; Fei,Bingyuan; Fang,Xuedong; Ma,Tonghui; Wang,Dongxin

doi:10.3892/or.2018.6695

miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer

Authors:
- Zhuo Liu
- Miao Yu
- Bingyuan Fei
- Xuedong Fang
- Tonghui Ma
- Dongxin Wang
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Affiliations: Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Jilin Cancer Hospital, Changchun, Jilin 130021, P.R. China
Published online on: September 10, 2018 https://doi.org/10.3892/or.2018.6695
Pages: 2955-2963

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Abstract

Pyruvate dehydrogenase A1 (PDHA1) is a component of the pyruvate dehydrogenase enzyme complex, which links glycolysis and the tricarboxylic acid cycle, and is important for cancer metabolism shift. PDHA1 downregulation has been revealed in several types of cancer to enhance glycolysis. However, the role of PDHA1 in gastric cancer remains largely unknown. In the present study, we found that PDHA1 was significantly downregulated in gastric cancer, and associated with poor prognosis. PDHA1 downregulation promoted gastric cancer glycolysis and cancer progression. miR‑21‑5p directly targeted PDHA1 to suppress PDHA1 expression, and promote glycolysis as well as cell proliferation in gastric cancer. Moreover, miR‑21‑5p was significantly upregulated in gastric cancer and negatively associated with PDHA1 expression in gastric cancer samples. Our results indicated that miR‑21‑5p targeted PDHA1 to regulate a metabolic switch and cancer progression in gastric cancer, and reveal the potential role of the miR‑21‑5p/PDHA1 axis in gastric cancer treatment.

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