Open Access

The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis (Review)

  • Authors:
    • Stella Baliou
    • Maria Adamaki
    • Demetrios A. Spandidos
    • Anthony M. Kyriakopoulos
    • Ioannis Christodoulou
    • Vassilis Zoumpourlis
  • View Affiliations

  • Published online on: December 20, 2018     https://doi.org/10.3892/wasj.2018.6
  • Pages: 3-19
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Microbiota is receiving significant attention in the research field, given that it is essential in homeostasis and an indirect modulator of diseases, such as cancer. Humans harbor a multitude of microorganisms that affect both human health and disease. Colorectal cancer is a genetic disease that is composed of distinct subtypes. In all cases, the intestinal microbiota has recently emerged as a crucial factor that promotes tumor growth at all stages through various mechanisms, such as the modulation of inflammation, the stimulation of DNA damage and toxic metabolite synthesis. In this review, we assess the contribution of the gut microbiome to homeostasis, its role as a potentiator or blocker of tumor progression and the underlying molecular mechanisms; we harness human data from both meta‑omics analyses and studies using animal models. Furthermore, we evaluate the ways through which microbes can be manipulated for diagnostic and prognostic purposes, and how they respond to chemotherapy or immunotherapy. Mounting evidence suggests that the microbiota may be used for the development of novel therapeutic strategies against colon cancer.

Related Articles

Journal Cover

January 2019
Volume 1 Issue 1

Print ISSN: 0000-0000
Online ISSN:000-0000

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Baliou, S., Adamaki, M., Spandidos, D.A., Kyriakopoulos, A.M., Christodoulou, I., & Zoumpourlis, V. (2019). The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis (Review). World Academy of Sciences Journal, 1, 3-19. https://doi.org/10.3892/wasj.2018.6
MLA
Baliou, S., Adamaki, M., Spandidos, D. A., Kyriakopoulos, A. M., Christodoulou, I., Zoumpourlis, V."The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis (Review)". World Academy of Sciences Journal 1.1 (2019): 3-19.
Chicago
Baliou, S., Adamaki, M., Spandidos, D. A., Kyriakopoulos, A. M., Christodoulou, I., Zoumpourlis, V."The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis (Review)". World Academy of Sciences Journal 1, no. 1 (2019): 3-19. https://doi.org/10.3892/wasj.2018.6