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Article

A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients

  • Authors:
    • Zhanjun Guo
    • Hongjing Wang
    • Yantao Li
    • Bin Li
    • Cuiqiao Li
    • Cuimin Ding
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 545-548
    |
    Published online on: March 29, 2013
       https://doi.org/10.3892/br.2013.92
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Abstract

MicroRNA (miRNA)‑related single nucleotide polymorphisms (miR‑SNPs) in miRNA processing machinery genes affect cancer risk, treatment efficacy and patient prognosis. A miR‑SNP of rs11077 located in the 3'UTR of miRNA processing machinery gene XPO5 was examined in small cell lung cancer (SCLC) patients to evaluate its association with cancer survival. A total of 42 patients were enrolled in the present study and genotyped for rs11077 and survival was assessed using the Kaplan‑Meier method, as well as univariate and multivariate analyses. The AA genotype of rs11077 was identified for its significant association with better survival time (P=0.023). In addition, rs11077 was found to associate independently with overall survival in SCLC patients by multivariate analysis (relative risk 2.469; 95% CI, 1.088‑5.603; P=0.031). The findings of this study suggest that although miR-SNP studies for miRNA processing machinery genes are still at an early age, miR-SNPs have an impact on cancer survival. In conclusion, a miR-SNP in the 3'UTR region of the XPO5 gene was identified as an independent prognostic marker for survival of advanced SCLC patients.
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1. 

Adjei AA, Marks RS and Bonner JA: Current guidelines for the management of small cell lung cancer. Mayo Clin Proc. 74:809–816. 1999. View Article : Google Scholar : PubMed/NCBI

2. 

Simon GR and Wagner H: American College of Chest Physicians. Small cell lung cancer. Chest. 123(Supp 1): 259S–271S. 2003. View Article : Google Scholar : PubMed/NCBI

3. 

National Comprehensive Cancer Network: National Comprehensive Cancer Network practice guidelines in oncology v. 1.2007: small cell lung cancer. Available at: http://www.nccn.org/professionals/physician_gls/PDF/sclc.pdfuri. Accessed January 9, 2007.

4. 

Hyde L, Yee J, Wilson R and Panto ME: Cell type and the natural history of lung cancer. JAMA. 193:52–54. 1965. View Article : Google Scholar : PubMed/NCBI

5. 

Lassen U, Osterlind K, Hansen M, Dombernowsky P, Bergman B and Hansen HH: Longterm survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years - an analysis of 1,714 consecutive patients. J Clin Oncol. 13:1215–1220. 1995.PubMed/NCBI

6. 

Rawson NS and Peto J: An overview of prognostic factors in small cell lung cancer. A report from the Subcommittee for the Management of Lung Cancer of the United Kingdom Coordinating Committee on Cancer Research. Br J Cancer. 61:597–604. 1990. View Article : Google Scholar : PubMed/NCBI

7. 

Knez L, Sodja E, Kern I, Košnik M and Cufer T: Predictive value of multidrug resistance protein, topoisomerases II and ERCC1 in small cell lung cancer: a systematic review. Lung Cancer. 72:271–279. 2011. View Article : Google Scholar : PubMed/NCBI

8. 

Kin YH, Ishii G, Goto K, Ota S, Kubota K, Murata Y, Mishima M, Saijo N, Nishiwaki Y and Ochiai A: Expression of the breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer. Lung Cancer. 65:105–111. 2009. View Article : Google Scholar : PubMed/NCBI

9. 

Ding C, Li R, Peng J, Li S and Guo Z: A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer. Exp Ther Med. 3:689–692. 2012.

10. 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11. 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

12. 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

13. 

Cullen BR: Transcription and processing of human microRNA precursors. Mol Cell. 16:861–865. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

15. 

Yi R, Qin Y, Macara IG and Cullen BR: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17:3011–3016. 2003. View Article : Google Scholar : PubMed/NCBI

16. 

Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K and Shiekhattar R: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 436:740–744. 2005. View Article : Google Scholar : PubMed/NCBI

17. 

Ryan BM, Robles AI and Harris CC: Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 10:389–402. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Guo Z, Wu C, Wang X, Wang C, Zhang R and Shan B: A polymorphism at the miR-502 binding site in the 3′-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome. Int J Cancer. 131:1318–1322. 2012.

19. 

Campayo M, Navarro A, Viñolas N, Tejero R, Muñoz C, Diaz T, Marrades R, Cabanas ML, Gimferrer JM, Gascon P, Ramirez J and Monzo M: A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma. PLoS One. 6:e225092011. View Article : Google Scholar : PubMed/NCBI

20. 

de Larrea CF, Navarro A, Tejero R, Tovar N, Díaz T, Cibeira MT, Rosiñol L, Ferrer G, Rovira M, Rozman M, Monzó M and Bladé J: Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. Clin Cancer Res. 18:3697–3704. 2012.PubMed/NCBI

21. 

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar

22. 

Hummel R, Hussey DJ and Haier J: MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types. Eur J Cancer. 46:298–311. 2010. View Article : Google Scholar : PubMed/NCBI

23. 

Lund E, Güttinger S, Calado A, Dahlberg JE and Kutay U: Nuclear export of microRNA precursors. Science. 303:95–98. 2004. View Article : Google Scholar

24. 

Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz S Jr and Esteller M: A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell. 18:303–315. 2010. View Article : Google Scholar : PubMed/NCBI

25. 

Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA and Wu X: Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Cancer Prev Res (Phila). 1:460–469. 2008. View Article : Google Scholar : PubMed/NCBI

26. 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Ménard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M and Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, Wang H, Li Y, Li B, Li C and Ding C: A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients. Biomed Rep 1: 545-548, 2013.
APA
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., & Ding, C. (2013). A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients. Biomedical Reports, 1, 545-548. https://doi.org/10.3892/br.2013.92
MLA
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., Ding, C."A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients". Biomedical Reports 1.4 (2013): 545-548.
Chicago
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., Ding, C."A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients". Biomedical Reports 1, no. 4 (2013): 545-548. https://doi.org/10.3892/br.2013.92
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, Wang H, Li Y, Li B, Li C and Ding C: A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients. Biomed Rep 1: 545-548, 2013.
APA
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., & Ding, C. (2013). A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients. Biomedical Reports, 1, 545-548. https://doi.org/10.3892/br.2013.92
MLA
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., Ding, C."A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients". Biomedical Reports 1.4 (2013): 545-548.
Chicago
Guo, Z., Wang, H., Li, Y., Li, B., Li, C., Ding, C."A microRNA‑related single nucleotide polymorphism of the XPO5 gene is associated with survival of small cell lung cancer patients". Biomedical Reports 1, no. 4 (2013): 545-548. https://doi.org/10.3892/br.2013.92
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