Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-2024 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 20 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review

  • Authors:
    • Andrea Marino
    • Giovanni Cacciaguerra
    • Serena Spampinato
    • Monica Palermo
    • Arturo Biasco
    • Emanuele Liotta
    • Salvatore Cocuzza
    • Emmanuele Venanzi Rullo
    • Giuseppe Nunnari
    • Piero Pavone
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Catania, ARNAS Garibaldi Hospital, I-95122 Catania, Italy, Department of Clinical and Experimental Medicine, Section of Paediatrics and Child Neuropsychiatry, School of Specialization in Paediatrics, University of Catania, I-95124 Catania, Italy, Department of Medical Surgical Sciences and Advanced Technologies ‘GF Ingrassia’, Radiology Unit 1, University of Catania, I-95125 Catania, Italy, Department of Medical and Surgical Sciences and Advanced Technologies ‘GF Ingrassia’, ENT Section, University of Catania, I-95124 Catania, Italy, Department of Clinical and Experimental Medicine, University of Messina, I-98124 Messina, Italy
    Copyright: © Marino et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 83
    |
    Published online on: March 27, 2024
       https://doi.org/10.3892/br.2024.1771
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection usually affects the respiratory system; however, a number of atypical manifestations of this disease have also been reported, especially in children. The present study reports a case of a 12-year-old presenting with right unilateral parotitis and sialadenitis and SARS-CoV-2 infection. The young patient, after a 3-day history of fever, was brought to our clinic (Polyclinic University Hospital ‘G. Rodolico’, Catania, Italy) for the sudden onset of unilateral parotitis accompanied by sialadenitis and hyperaemia of the skin, which was tender to touch. The SARS-CoV-2 molecular swab was positive; the ultrasound of the affected region showed an increase in the volume of the parotid and sublingual gland and reactive lymph nodes compatible with parotitis and sialadenitis. This case suggests that, in the present Coronavirus disease 2019 pandemic, SARS-CoV-2 should be included in the differential diagnosis of parotitis and sialadenitis along with mumps and flue. Notably, a respiratory panel and serology for other potential causes are needed in case of parotitis-like disease.
View Figures

Figure 1

View References

1 

Marino A, Munafò A, Augello E, Bellanca CM, Bonomo C, Ceccarelli M, Musso N, Cantarella G, Cacopardo B and Bernardini R: Sarilumab administration in COVID-19 patients: Literature review and considerations. Infect Dis Rep. 14:360–371. 2022.PubMed/NCBI View Article : Google Scholar

2 

Zimmermann P and Curtis N: Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 39:355–368. 2020.PubMed/NCBI View Article : Google Scholar

3 

Mao R, Qiu Y, He JS, Tan JY, Li XH, Liang J, Shen J, Zhu LR, Chen Y, Iacucci M, et al: Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 5:667–678. 2020.PubMed/NCBI View Article : Google Scholar

4 

Cosentino F, Moscatt V, Marino A, Pampaloni A, Scuderi D, Ceccarelli M, Benanti F, Gussio M, Larocca L, Boscia V, et al: Clinical characteristics and predictors of death among hospitalized patients infected with SARS-CoV-2 in Sicily, Italy: A retrospective observational study. Biomed Rep. 16(34)2022.PubMed/NCBI View Article : Google Scholar

5 

Pagliari D, Marra A and Cosentini R: Atypical manifestations of COVID-19: To know signs and symptoms to recognize the whole disease in the emergency department. Intern Emerg Med. 16:1407–1410. 2021.PubMed/NCBI View Article : Google Scholar

6 

Yang Z, Chen X, Huang R, Li S, Lin D, Yang Z, Sun H, Liu G, Qiu J, Tang Y, et al: Atypical presentations of coronavirus disease 2019 (COVID-19) from onset to readmission. BMC Infect Dis. 21(127)2021.PubMed/NCBI View Article : Google Scholar

7 

Binmadi NO, Aljohani S, Alsharif MT, Almazrooa SA and Sindi AM: Oral manifestations of COVID-19: A cross-sectional study of their prevalence and association with disease severity. J Clin Med. 11(4461)2022.PubMed/NCBI View Article : Google Scholar

8 

Zachariah P: COVID-19 in children. Infect Dis Clin North Am. 36:1–14. 2022.PubMed/NCBI View Article : Google Scholar

9 

Kachru S and Kaul D: COVID-19 manifestations in children. Curr Med Res Pract. 10:186–188. 2020.PubMed/NCBI View Article : Google Scholar

10 

Friedrich RE, Droste TL, Angerer F, Popa B, Koehnke R, Gosau M and Knipfer C: COVID-19-associated parotid gland abscess. In Vivo. 36:1349–1353. 2022.PubMed/NCBI View Article : Google Scholar

11 

Maegawa K and Nishioka H: COVID-19-associated parotitis and sublingual gland sialadenitis. BMJ Case Rep. 15(e251730)2022.PubMed/NCBI View Article : Google Scholar

12 

Brandini DA, Takamiya AS, Thakkar P, Schaller S, Rahat R and Naqvi AR: Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 31(e2226)2021.PubMed/NCBI View Article : Google Scholar

13 

Sayed MA and Abdelhakeem M: Typical and atypical clinical presentation of COVID-19 infection in children in the top of pandemic in el-minia governorate (two center experience). Mediterr J Hematol Infect Dis. 14(e2022002)2022.PubMed/NCBI View Article : Google Scholar

14 

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T and Chen Q: High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 12(8)2020.PubMed/NCBI View Article : Google Scholar

15 

Montazersaheb S, Hosseiniyan Khatibi SM, Hejazi MS, Tarhriz V, Farjami A, Ghasemian Sorbeni F, Farahzadi R and Ghasemnejad T: COVID-19 infection: An overview on cytokine storm and related interventions. Virol J. 19(92)2022.PubMed/NCBI View Article : Google Scholar

16 

Campanella E, Marino A, Ceccarelli M, Gussio M, Cosentino F, Moscatt V, Icali C, Nunnari G, Celesia BM and Acopardo B: Pain crisis management in a patient with sickle cell disease during SARS-CoV-2 infection: A case report and literature review. World Acad Sci J. 4(14)2022.

17 

Wu X, Xiang M, Jing H, Wang C, Novakovic VA and Shi J: Damage to endothelial barriers and its contribution to long COVID. Angiogenesis. 27:5–22. 2024.PubMed/NCBI View Article : Google Scholar

18 

Spampinato S, Pavone P, Cacciaguerra G, Cocuzza S, Venanzi Rullo E, Marino S, Marino A and Nunnari G: Coronavirus OC43 and influenza H3N2 concomitant unilateral parotitis: The importance of laboratory tests in mumps-like parotitis. Pathogens. 12(1309)2023.PubMed/NCBI View Article : Google Scholar

19 

Nunez-Castilla J, Stebliankin V, Baral P, Balbin CA, Sobhan M, Cickovski T, Mondal AM, Narasimhan G, Chapagain P, Mathee K and Siltberg-Liberles J: Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 spike and human proteins. Viruses. 14(1415)2022.PubMed/NCBI View Article : Google Scholar

20 

Pavone P, Ceccarelli M, Taibi R, La Rocca G and Nunnari G: Outbreak of COVID-19 infection in children: Fear and serenity. Eur Rev Med Pharmacol Sci. 24:4572–4575. 2020.PubMed/NCBI View Article : Google Scholar

21 

Pavone P, Marino S, Marino L, Cacciaguerra G, Guarneri C, Nunnari G, Taibi R, Marletta L and Falsaperla R: Chilblains-like lesions and SARS-CoV-2 in children: An overview in therapeutic approach. Dermatol Ther. 34(e14502)2021.PubMed/NCBI View Article : Google Scholar

22 

Rayan MA, Bader JA, Feras AA and Shaikha JA: COVID-19 associated parotitis in pediatrics. Glob J Pediatr Neonatal Care. 2:2020.

23 

Riad A, Kassem I, Badrah M and Klugar M: Acute parotitis as a presentation of COVID-19? Oral Dis. 28 (Suppl 1):S968–S969. 2022.PubMed/NCBI View Article : Google Scholar

24 

Wilson M and Pandey S: Parotitis. Emergency Management of Infectious Diseases: Second edition. pp126-128, 2023.

25 

Sharma S, Mahajan V and Gupta R: Unilateral acute parotitis: A novel manifestation of pediatric coronavirus disease. Indian Pediatr Case Rep. 2:200–203. 2022.

26 

Ekemen Keles Y, Karadag Oncel E, Baysal M, Kara Aksay A and Yılmaz Ciftdogan D: Acute parotitis in a 4-year-old in association with COVID-19. J Paediatr Child Health. 57:958–959. 2021.PubMed/NCBI View Article : Google Scholar

27 

Brehm R, Narayanam L and Chon G: COVID-19-associated parotitis in a 10-week-old male. Cureus. 14(e31054)2022.PubMed/NCBI View Article : Google Scholar

28 

Likitnukul S: COVID-19 associated parotitis in a 4-year-old boy. J Paediatr Child Health. 58:1911–1912. 2022.PubMed/NCBI View Article : Google Scholar

29 

Erdem H, Hargreaves S, Ankarali H, Caskurlu H, Ceviker SA, Bahar-Kacmaz A, Meric-Koc M, Altindis M, Yildiz-Kirazaldi Y, Kizilates F, et al: Managing adult patients with infectious diseases in emergency departments: International ID-IRI study. J Chemother. 33:302–318. 2021.PubMed/NCBI View Article : Google Scholar

30 

Ludvigsson JF: Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 109:1088–1095. 2020.PubMed/NCBI View Article : Google Scholar

31 

Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Calò Carducci FI, Gabrovska N, Velizarova S, Prunk P, Osterman V, et al: COVID-19 in children and adolescents in Europe: A multinational, multicentre cohort study. Lancet Child Adolesc Health. 4:653–661. 2020.PubMed/NCBI View Article : Google Scholar

32 

Bialek S, Gierke R, Hughes M, McNamara LA, Pilishvili T and Skoff T: Coronavirus disease 2019 in children-United States, February 12-April 2, 2020. MMWR Morb Mortal Wkly Rep. 69:422–426. 2020.PubMed/NCBI View Article : Google Scholar

33 

Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, Banker SL, Giordano M, Manice CS, Diamond R, et al: Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a children's hospital in New York City, New York. JAMA Pediatr. 174(e202430)2020.PubMed/NCBI View Article : Google Scholar

34 

Parri N, Lenge M and Buonsenso D: Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in pediatric emergency departments in Italy. N Engl J Med. 383:187–190. 2020.PubMed/NCBI View Article : Google Scholar

35 

Cag Y, Al Madadha ME, Ankarali H, Cag Y, Demir Onder K, Seremet-Keskin A, Kizilates F, Čivljak R, Shehata G, Alay H, et al: Vaccine hesitancy and refusal among parents: An international ID-IRI survey. J Infect Dev Ctries. 16:1081–1088. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Marino A, Cacciaguerra G, Spampinato S, Palermo M, Biasco A, Liotta E, Cocuzza S, Venanzi Rullo E, Nunnari G, Pavone P, Pavone P, et al: SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review. Biomed Rep 20: 83, 2024.
APA
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E. ... Pavone, P. (2024). SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review. Biomedical Reports, 20, 83. https://doi.org/10.3892/br.2024.1771
MLA
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E., Cocuzza, S., Venanzi Rullo, E., Nunnari, G., Pavone, P."SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review". Biomedical Reports 20.5 (2024): 83.
Chicago
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E., Cocuzza, S., Venanzi Rullo, E., Nunnari, G., Pavone, P."SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review". Biomedical Reports 20, no. 5 (2024): 83. https://doi.org/10.3892/br.2024.1771
Copy and paste a formatted citation
x
Spandidos Publications style
Marino A, Cacciaguerra G, Spampinato S, Palermo M, Biasco A, Liotta E, Cocuzza S, Venanzi Rullo E, Nunnari G, Pavone P, Pavone P, et al: SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review. Biomed Rep 20: 83, 2024.
APA
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E. ... Pavone, P. (2024). SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review. Biomedical Reports, 20, 83. https://doi.org/10.3892/br.2024.1771
MLA
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E., Cocuzza, S., Venanzi Rullo, E., Nunnari, G., Pavone, P."SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review". Biomedical Reports 20.5 (2024): 83.
Chicago
Marino, A., Cacciaguerra, G., Spampinato, S., Palermo, M., Biasco, A., Liotta, E., Cocuzza, S., Venanzi Rullo, E., Nunnari, G., Pavone, P."SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review". Biomedical Reports 20, no. 5 (2024): 83. https://doi.org/10.3892/br.2024.1771
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team