Effects of carboxymethyl-glucan from Saccharomyces cerevisiae  on the peripheral blood cells of patients with advanced prostate cancer

Magnani,Marciane; Castro-Gomez,Raul   Hernan; Nobrega Aoki,Mateus; Pereira Gregório,Emerson; Libos,Farid; Ehara Watanabe,Maria Angelica

doi:10.3892/etm.2010.121

September-October 2010 Volume 1 Issue 5

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September-October 2010 Volume 1 Issue 5

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Article

Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer

Authors:
- Marciane Magnani
- Raul Hernan Castro-Gomez
- Mateus Nobrega Aoki
- Emerson Pereira Gregório
- Farid Libos
- Maria Angelica Ehara Watanabe
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Affiliations: Departamento de Ciência e Tecnologia de Alimentos, Universidade Estadual de Londrina, Londrina, Paraná, Brasil, Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brasil, Instituto do Câncer de Londrina, Londrina, Paraná, Brasil
Pages: 859-862
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Published online on: July 20, 2010

https://doi.org/10.3892/etm.2010.121
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Abstract

Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1-3)(1-6) glucan that is well known for its immunostimulant and hematopoiesis-enhancing activities. In this clinical trial, we assessed the effects of oral CM-G administration on the peripheral blood cells of patients with advanced prostate cancer, and examined its ability to alter hepatic and renal function. After CM-G administration, the total leukocyte count increased significantly (p≤0.02), with no associated changes in the lifestyle habits of the patients. A significant increase (p≤0.001) was also observed for red blood cell, hematocrit, hemoglobin and platelet counts. No changes were observed in hepatic or renal function after CM-G administration, and no side effects associated with its use were recorded. These results suggest that using CM-G as an adjuvant to cancer treatment may improve the health parameters of prostate cancer patients.

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