Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer

  • Authors:
    • Marciane Magnani
    • Raul Hernan Castro-Gomez
    • Mateus Nobrega Aoki
    • Emerson Pereira Gregório
    • Farid Libos
    • Maria Angelica Ehara Watanabe
  • View Affiliations

  • Published online on: July 20, 2010     https://doi.org/10.3892/etm.2010.121
  • Pages: 859-862
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Abstract

Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1-3)(1-6) glucan that is well known for its immunostimulant and hematopoiesis-enhancing activities. In this clinical trial, we assessed the effects of oral CM-G administration on the peripheral blood cells of patients with advanced prostate cancer, and examined its ability to alter hepatic and renal function. After CM-G administration, the total leukocyte count increased significantly (p≤0.02), with no associated changes in the lifestyle habits of the patients. A significant increase (p≤0.001) was also observed for red blood cell, hematocrit, hemoglobin and platelet counts. No changes were observed in hepatic or renal function after CM-G administration, and no side effects associated with its use were recorded. These results suggest that using CM-G as an adjuvant to cancer treatment may improve the health parameters of prostate cancer patients.
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September-October 2010
Volume 1 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Magnani M, Castro-Gomez RH, Nobrega Aoki M, Pereira Gregório E, Libos F and Ehara Watanabe MA: Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer. Exp Ther Med 1: 859-862, 2010.
APA
Magnani, M., Castro-Gomez, R.H., Nobrega Aoki, M., Pereira Gregório, E., Libos, F., & Ehara Watanabe, M.A. (2010). Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer. Experimental and Therapeutic Medicine, 1, 859-862. https://doi.org/10.3892/etm.2010.121
MLA
Magnani, M., Castro-Gomez, R. H., Nobrega Aoki, M., Pereira Gregório, E., Libos, F., Ehara Watanabe, M. A."Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer". Experimental and Therapeutic Medicine 1.5 (2010): 859-862.
Chicago
Magnani, M., Castro-Gomez, R. H., Nobrega Aoki, M., Pereira Gregório, E., Libos, F., Ehara Watanabe, M. A."Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer". Experimental and Therapeutic Medicine 1, no. 5 (2010): 859-862. https://doi.org/10.3892/etm.2010.121