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Inhibition of tumor angiogenesis by oral etoposide

  • Authors:
    • Dipak Panigrahy
    • Arja Kaipainen
    • Catherine E. Butterfield
    • Deviney M. Chaponis
    • Andrea M. Laforme
    • Judah Folkman
    • Mark W. Kieran
  • View Affiliations / Copyright

    Affiliations: Vascular Biology Program, Children's Hospital Boston, Department of Surgery, Harvard Medical School, Boston, MA, USA, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada, Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 739-746
    |
    Published online on: July 21, 2010
       https://doi.org/10.3892/etm.2010.127
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Abstract

The chemotherapeutic agent etoposide is a topoisomerase II inhibitor widely used for cancer therapy. Low-dose oral etoposide, administered at close regular intervals, has potent anti-tumor activity in patients who are refractory to intravenous etoposide; however, the mechanism remains unclear. Since endothelial cells may be more sensitive than tumor cells to chemotherapy agents, we determined the effects of etoposide alone and in combination with oral cyclooxygenase-2 inhibitors and peroxisome-proliferator activated receptor γ ligands on angiogenesis and tumor growth in xenograft tumor models. Optimal anti-angiogenic (metronomic) and anti-tumor doses of etoposide on angiogenesis, primary tumor growth and metastasis were established alone and in combination therapy. Etoposide inhibited endothelial and tumor cell proliferation, decreased vascular endothelial growth factor (VEGF) production by tumor cells and suppressed endothelial tube formation at non-cytotoxic concentrations. In our in vivo studies, oral etoposide inhibited fibroblast growth factor 2 and VEGF-induced corneal neovascularization, VEGF-induced vascular permeability and increased levels of the endogenous angiogenesis inhibitor endostatin in mice. In addition, etoposide inhibited Lewis lung carcinoma (LLC) and human glioblastoma (U87) primary tumor growth as well as spontaneous lung metastasis in a LLC resection model. Furthermore, etoposide had synergistic anti-tumor activity in combination with celecoxib and rosiglitazone, which are also oral anti-angiogenic and anti-tumor agents. Etoposide inhibits angiogenesis in vitro and in vivo by indirect and direct mechanisms of action. Combining etoposide with celecoxib and rosiglitazone increases its efficacy and merits further investigation in future clinical trials to determine the potential usefulness of etoposide in combinatory anti-angiogenic chemotherapy.
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View References

1. 

Browder T, Butterfield CE, Kraling BM, et al: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. 60:1878–1886. 2000.PubMed/NCBI

2. 

Klement G, Baruchel S, Rak J, et al: Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest. 105:15–24. 2000. View Article : Google Scholar : PubMed/NCBI

3. 

Hanahan D, Bergers G and Bergsland E: Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest. 105:1045–1047. 2000. View Article : Google Scholar : PubMed/NCBI

4. 

Kerbel RS and Kamen BA: The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 4:423–436. 2004. View Article : Google Scholar : PubMed/NCBI

5. 

Folkman J: Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 6:273–286. 2007. View Article : Google Scholar : PubMed/NCBI

6. 

Man S, Bocci G, Francia G, et al: Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res. 62:2731–2735. 2002.

7. 

Kieran MW, Turner CD, Rubin J, et al: A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive cancer. J Pediatr Hematol Oncol. 27:573–581. 2005. View Article : Google Scholar : PubMed/NCBI

8. 

Vogt T, Hafner C, Bross K, et al: Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors. Cancer. 98:2251–2256. 2003. View Article : Google Scholar : PubMed/NCBI

9. 

Sterba J, Valik D, Mudry P, et al: Combined biodifferentiating and antiangiogenic oral metronomic therapy is feasible and effective in relapsed solid tumors in children: single-center pilot study. Onkologie. 29:308–313. 2006. View Article : Google Scholar : PubMed/NCBI

10. 

Aisner J and Lee EJ: Etoposide. Current and future status. Cancer. 67:215–219. 1991. View Article : Google Scholar : PubMed/NCBI

11. 

Kakolyris S, Samonis G, Koukourakis M, et al: Treatment of non-small cell lung cancer with prolonged oral etoposide. Am J Clin Oncol. 21:505–508. 1998. View Article : Google Scholar : PubMed/NCBI

12. 

Ashley DM, Meier L, Kerby T, et al: Response of recurrent medulloblastoma to low-dose oral etoposide. J Clin Oncol. 14:1922–1927. 1996.PubMed/NCBI

13. 

Alici S, Saip P, Eralp Y, Aydiner A and Topuz E: Oral etoposide (VP16) in platinum-resistant epithelial ovarian cancer (EOC). Am J Clin Oncol. 26:358–362. 2003. View Article : Google Scholar : PubMed/NCBI

14. 

Martin M, Lluch A, Casado A, et al: Clinical activity of chronic oral etoposide in previously treated metastatic breast cancer. J Clin Oncol. 12:986–991. 1994.PubMed/NCBI

15. 

Kebudi R, Gorgun O and Ayan I: Oral etoposide for recurrent/progressive sarcomas of childhood. Pediatr Blood Cancer. 42:320–324. 2004. View Article : Google Scholar : PubMed/NCBI

16. 

Cavalli F, Sonntag RW, Jungi F, Senn HJ and Brunner KW: VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules. Cancer Treat Rep. 62:473–475. 1978.PubMed/NCBI

17. 

Bontenbal M, Planting AS, Verweij J, et al: Second-line chemotherapy with long-term low-dose oral etoposide in patients with advanced breast cancer. Breast Cancer Res Treat. 34:185–189. 1995. View Article : Google Scholar : PubMed/NCBI

18. 

Folkman J: Tumor angiogenesis. Cancer Medicine. Holland JF, Frei EI, Bast RCJ, Kufe DW, Pollock RE and Weichselbaum RR: 5th edition. BC Decker Inc; Ontario: pp. 132–152. 2000

19. 

Ma G, Masuzawa M, Hamada Y, et al: Treatment of murine angiosarcoma with etoposide, TNP-470 and prednisolone. J Dermatol Sci. 24:126–133. 2000. View Article : Google Scholar : PubMed/NCBI

20. 

Drevs J, Fakler J, Eisele S, et al: Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Res. 24:1759–1763. 2004.PubMed/NCBI

21. 

O'Reilly MS, Holmgren L, Shing Y, et al: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:315–328. 1994.PubMed/NCBI

22. 

Panigrahy D, Singer S, Shen LQ, et al: PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest. 110:923–932. 2002.

23. 

Kamiyama H, Takano S, Tsuboi K and Matsumura A: Anti-angiogenic effects of SN38 (active metabolite of irinotecan): inhibition of hypoxia-inducible factor 1 alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) expression of glioma and growth of endothelial cells. J Cancer Res Clin Oncol. 131:205–213. 2005. View Article : Google Scholar

24. 

Dvorak HF: Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 20:4368–4380. 2002. View Article : Google Scholar

25. 

Hong SY, Lee MH, Kim KS, et al: Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model. World J Gastroenterol. 10:1191–1197. 2004.

26. 

Sant VP, Nagarsenker MS, Rao SG and Gude RP: Sterically stabilized etoposide liposomes: evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized pentoxifylline liposomes in mice. Cancer Biother Radiopharm. 18:811–817. 2003. View Article : Google Scholar

27. 

Masferrer JL, Leahy KM, Koki A, et al: Antiangiogenic and antitumor activities of cyclooxgenase-2 inhibitors. Cancer Res. 60:1306–1311. 2000.PubMed/NCBI

28. 

Kerbel RS: Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science. 312:1171–1175. 2006. View Article : Google Scholar : PubMed/NCBI

29. 

Shaked Y, Emmenegger U, Francia G, et al: Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res. 65:7045–7051. 2005. View Article : Google Scholar : PubMed/NCBI

30. 

Bocci G, Nicolaou KC and Kerbel RS: Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 62:6938–6943. 2002.

31. 

Hamano Y, Sugimoto H, Soubasakos MA, et al: Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 64:1570–1574. 2004. View Article : Google Scholar : PubMed/NCBI

32. 

Needle MN, Molloy PT, Geyer JR, et al: Phase II study of daily oral etoposide in children with recurrent brain tumors and other solid tumors. Med Pediatr Oncol. 29:28–32. 1997. View Article : Google Scholar : PubMed/NCBI

33. 

Doll DC, Kasper LM, Taetle R and List AF: Treatment with low-dose oral etoposide in patients with myelodysplastic syndromes. Leuk Res. 22:7–12. 1998. View Article : Google Scholar : PubMed/NCBI

34. 

Hainsworth JD: Extended-schedule oral etoposide in selected neoplasms and overview of administration and scheduling issues. Drugs. 58(Suppl 3): 51–56. 1999. View Article : Google Scholar : PubMed/NCBI

35. 

Zucchetti M, Pagani O, Torri V, et al: Clinical pharmacology of chronic oral etoposide in patients with small cell and non-small cell lung cancer. Clin Cancer Res. 1:1517–1524. 1995.PubMed/NCBI

36. 

Lowis SP, Newell DR and Pearson AD: Exposure and schedule dependency of etoposide in neuroblastoma and leukaemia cells in vitro. Eur J Cancer. 31A:622–626. 1995. View Article : Google Scholar : PubMed/NCBI

37. 

Dombernowsky P and Nissen NI: Schedule dependency of the antileukemic activity of the podophyllotoxin-derivative VP 16-213 (NSC-141540) in L1210 leukemia. Acta Pathol Microbiol Scand [A]. 81:715–724. 1973.PubMed/NCBI

38. 

Schirner M, Hoffmann J, Menrad A and Schneider MR: Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models. Clin Cancer Res. 4:1331–1336. 1998.

39. 

Nilsson UW and Dabrosin C: Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo. Cancer Res. 66:4789–4794. 2006. View Article : Google Scholar : PubMed/NCBI

40. 

Ma L, del Soldato P and Wallace JL: Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: shifting the angiogenic balance. Proc Natl Acad Sci USA. 99:13243–13247. 2002. View Article : Google Scholar : PubMed/NCBI

41. 

Nagashima M, Asano G and Yoshino S: Imbalance in production between vascular endothelial growth factor and endostatin in patients with rheumatoid arthritis. J Rheumatol. 27:2339–2342. 2000.PubMed/NCBI

42. 

Yu JL, Rak JW, Coomber BL, Hicklin DJ and Kerbel RS: Effect of p53 status on tumor response to antiangiogenic therapy. Science. 295:1526–1528. 2002. View Article : Google Scholar : PubMed/NCBI

43. 

Yap R, Veliceasa D, Emmenegger U, et al: Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation anti-angiogenic strategy. Clin Cancer Res. 11:6678–6685. 2005. View Article : Google Scholar : PubMed/NCBI

44. 

Girnun GD, Naseri E, Vafai SB, et al: Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell. 11:395–406. 2007. View Article : Google Scholar : PubMed/NCBI

45. 

Khafif A, Canfield VA, Syzek EJ and Medina JE: Results of phase I–II trial of concomitant hyperfractionated radiation and oral etoposide (VP-16) in patients with unresectable squamous cell carcinoma of the head and neck. Am J Otolaryngol. 24:1–5. 2003.

46. 

Vaishampayan U, Fontana J, Du W and Hussain M: Phase II trial of estramustine and etoposide in androgen-sensitive metastatic prostate carcinoma. Am J Clin Oncol. 27:550–554. 2004. View Article : Google Scholar : PubMed/NCBI

47. 

Bocci G, Tuccori M, Emmenegger U, et al: Cyclophosphamidemethotrexate ‘metronomic’ chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation. Ann Oncol. 16:1243–1252. 2005.

48. 

Vanchieri C: When will the U.S. flinch at cancer drug prices? J Natl Cancer Inst. 97:624–626. 2005. View Article : Google Scholar : PubMed/NCBI

49. 

Emmenegger U, Morton GC, Francia G, et al: Low-dose metronomic daily cyclophosphamide and weekly tirapazamine: a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia. Cancer Res. 66:1664–1674. 2006. View Article : Google Scholar

50. 

Verdrengh M and Tarkowski A: Impact of topoisomerase II inhibition on cytokine and chemokine production. Inflamm Res. 52:148–153. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Panigrahy D, Kaipainen A, Butterfield CE, Chaponis DM, Laforme AM, Folkman J and Kieran MW: Inhibition of tumor angiogenesis by oral etoposide. Exp Ther Med 1: 739-746, 2010.
APA
Panigrahy, D., Kaipainen, A., Butterfield, C.E., Chaponis, D.M., Laforme, A.M., Folkman, J., & Kieran, M.W. (2010). Inhibition of tumor angiogenesis by oral etoposide. Experimental and Therapeutic Medicine, 1, 739-746. https://doi.org/10.3892/etm.2010.127
MLA
Panigrahy, D., Kaipainen, A., Butterfield, C. E., Chaponis, D. M., Laforme, A. M., Folkman, J., Kieran, M. W."Inhibition of tumor angiogenesis by oral etoposide". Experimental and Therapeutic Medicine 1.5 (2010): 739-746.
Chicago
Panigrahy, D., Kaipainen, A., Butterfield, C. E., Chaponis, D. M., Laforme, A. M., Folkman, J., Kieran, M. W."Inhibition of tumor angiogenesis by oral etoposide". Experimental and Therapeutic Medicine 1, no. 5 (2010): 739-746. https://doi.org/10.3892/etm.2010.127
Copy and paste a formatted citation
x
Spandidos Publications style
Panigrahy D, Kaipainen A, Butterfield CE, Chaponis DM, Laforme AM, Folkman J and Kieran MW: Inhibition of tumor angiogenesis by oral etoposide. Exp Ther Med 1: 739-746, 2010.
APA
Panigrahy, D., Kaipainen, A., Butterfield, C.E., Chaponis, D.M., Laforme, A.M., Folkman, J., & Kieran, M.W. (2010). Inhibition of tumor angiogenesis by oral etoposide. Experimental and Therapeutic Medicine, 1, 739-746. https://doi.org/10.3892/etm.2010.127
MLA
Panigrahy, D., Kaipainen, A., Butterfield, C. E., Chaponis, D. M., Laforme, A. M., Folkman, J., Kieran, M. W."Inhibition of tumor angiogenesis by oral etoposide". Experimental and Therapeutic Medicine 1.5 (2010): 739-746.
Chicago
Panigrahy, D., Kaipainen, A., Butterfield, C. E., Chaponis, D. M., Laforme, A. M., Folkman, J., Kieran, M. W."Inhibition of tumor angiogenesis by oral etoposide". Experimental and Therapeutic Medicine 1, no. 5 (2010): 739-746. https://doi.org/10.3892/etm.2010.127
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