Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-February 2011 Volume 2 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2011 Volume 2 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma

  • Authors:
    • Hui-Ching Chuang
    • Chang-Han Chen
    • Chao-Cheng Huang
    • Fu-Min Fang
    • Hsin-Ting Tsai
    • Chih-Yen Chien
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan, R.O.C., Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan, R.O.C., Department of Radiation Oncology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan, R.O.C.
  • Pages: 63-67
    |
    Published online on: December 2, 2010
       https://doi.org/10.3892/etm.2010.168
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The functions of telomeric repeat-binding factor 1 (TRF1) and 2 (TRF2) in oral carcinogenesis are largely unexplored. This study examined the relationship between the expression of TRF1 and TRF2 and clinicopathological variables and survival in oral cavity squamous cell carcinoma (OCSCC). Western blotting and immunohistochemistry were used to evaluate the protein expression of TRF1 and TRF2 in paired OCSCC patient specimens. Expression of TRF1 and TRF2 was assessed by immunohistochemistry in 256 OCSCC patients who underwent tumor resection without previous radiotherapy. The results were analyzed using Fisher's exact test. Protein expression of TRF1 and TRF2 was significantly lower in the OCSCC than in the adjacent non-tumor tissue. Reduced TRF1 and TRF2 levels in 256 patients, as revealed by immunohistochemistry, were significantly associated with aggressive clinicopathological features, such as advanced tumor stage (p<0.001) and advanced tumor node metastasis stage (p<0.001). According to Kaplan-Meier analysis, reduced TRF1 expression was significantly correlated with an unfavorable cumulative 5-year overall survival rate (p<0.001). In conclusion, decreased expression of TRF1 was significantly associated with tumor progression and poor prognosis in OCSCC patients.
View Figures

Figure 1

Figure 2

View References

1. 

Shah JP and Singh B: Why the lack of progress for oral cancer? Lancet Oncol. 7:356–357. 2006. View Article : Google Scholar : PubMed/NCBI

2. 

Chien CY, Su CY, Chuang HC, et al: Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity. J Surg Oncol. 97:273–277. 2008. View Article : Google Scholar : PubMed/NCBI

3. 

Chen PH, Ko YC, Yang YH, et al: Important prognostic factors of long-term oropharyngeal carcinoma survivors in Taiwan. Oral Oncol. 40:847–855. 2004. View Article : Google Scholar : PubMed/NCBI

4. 

Matsuo JM, Patel SG, Singh B, et al: Clinical nodal stage is an independently significant predictor of distant failure in patients with squamous cell carcinoma of the larynx. Ann Surg. 238:412–421. 2003.PubMed/NCBI

5. 

Chien CY, Su CY, Chuang HC, et al: Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma. Oral Oncol. 45:798–802. 2009. View Article : Google Scholar : PubMed/NCBI

6. 

Chen CH, Chien CY, Huang CC, et al: Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity. Oncogene. 28:2723–2737. 2009. View Article : Google Scholar : PubMed/NCBI

7. 

Vaziri H, Schachter F, Uchida I, et al: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 52:661–667. 1993.PubMed/NCBI

8. 

Van Steensel B and de Lange T: Control of telomere length by the human telomeric protein TRF1. Nature. 385:740–743. 1997.

9. 

Smogorzewska A, van Steensel B, Bianchi A, et al: Control of human telomere length by TRF1 and TRF2. Mol Cell Biol. 20:1659–1668. 2000. View Article : Google Scholar : PubMed/NCBI

10. 

Sfeir A, Kosiyatrakul ST, Hockemeyer D, et al: Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138:90–103. 2009. View Article : Google Scholar : PubMed/NCBI

11. 

Van Steensel B, Smogorzewska A and de Lange T: TRF2 protects human telomeres from end-to-end fusions. Cell. 92:401–413. 1998.PubMed/NCBI

12. 

Ancelin K, Brunori M, Bauwens S, et al: Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol. 22:3474–3487. 2002. View Article : Google Scholar : PubMed/NCBI

13. 

Yamada K, Yagihashi A, Yamada M, et al: Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Anticancer Res. 22:1315–1320. 2002.PubMed/NCBI

14. 

Yamada M, Tsuji N, Nakamura M, et al: Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. Anticancer Res. 22:3303–3307. 2002.PubMed/NCBI

15. 

Miyachi K, Fujita M, Tanaka N, Sasaki K and Sunagawa M: Correlation between telomerase activity and telomeric-repeat binding factors in gastric cancer. J Exp Clin Cancer Res. 21:269–275. 2002.PubMed/NCBI

16. 

Lin X, Gu J, Lu C, Spitz MR and Wu X: Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res. 12:5720–5725. 2006. View Article : Google Scholar : PubMed/NCBI

17. 

Raynaud CM, Jang SJ, Nuciforo P, et al: Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. Ann Oncol. 19:1875–1881. 2008. View Article : Google Scholar : PubMed/NCBI

18. 

Frias C, Garcia-Aranda C, De Juan C, et al: Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. Lung Cancer. 60:416–425. 2008. View Article : Google Scholar : PubMed/NCBI

19. 

d’Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al: A DNA damage checkpoint response in telomere-initiated senescence. Nature. 426:194–198. 2003.PubMed/NCBI

20. 

Yajima T, Yagihashi A, Kameshima H, Kobayashi D, Hirata K and Watanabe N: Telomerase reverse transcriptase and telomeric-repeat binding factor protein 1 as regulators of telomerase activity in pancreatic cancer cells. Br J Cancer. 85:752–757. 2001. View Article : Google Scholar

21. 

Salhab M, Jiang WG, Newbold RF and Mokbel K: The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. Breast Cancer Res Treat. 109:35–46. 2008. View Article : Google Scholar

22. 

Feldser DM, Hackett JA and Greider CW: Telomere dysfunction and the initiation of genome instability. Nat Rev Cancer. 3:623–627. 2003. View Article : Google Scholar : PubMed/NCBI

23. 

Chong L, van Steensel B, Broccoli D, et al: A human telomeric protein. Science. 270:1663–1667. 1995. View Article : Google Scholar : PubMed/NCBI

24. 

Broccoli D, Smogorzewska A, Chong L and de Lange T: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet. 17:231–235. 1997. View Article : Google Scholar : PubMed/NCBI

25. 

Saito K, Yagihashi A, Nasu S, Izawa Y, et al: Gene expression for suppressors of telomerase activity (telomeric-repeat binding factors) in breast cancer. Jpn J Cancer Res. 93:253–258. 2002. View Article : Google Scholar : PubMed/NCBI

26. 

Yamada K, Yajima T, Yagihashi A, et al: Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic cells. Jpn J Cancer Res. 91:1278–1284. 2000. View Article : Google Scholar : PubMed/NCBI

27. 

La Torre D, de Divitiis O, Conti A, et al: Expression of telomeric repeat binding factor-1 in astroglial brain tumors. Neurosurgery. 56:802–810. 2005.PubMed/NCBI

28. 

Kishi S, Wulf G, Nakamura M and Lu KP: Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. Oncogene. 20:1497–1508. 2001. View Article : Google Scholar : PubMed/NCBI

29. 

Oh BK, Kim YJ, Park C and Park YN: Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol. 166:73–80. 2005. View Article : Google Scholar : PubMed/NCBI

30. 

Klapper W, Qian W, Schulte C and Parwaresch R: DNA damage transiently increases TRF2 mRNA expression and telomerase activity. Leukemia. 17:2007–2015. 2003. View Article : Google Scholar : PubMed/NCBI

31. 

Klapper W, Krams M, Qian W, Janssen D and Parwaresch R: Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation. Br J Cancer. 89:713–719. 2003. View Article : Google Scholar

32. 

Nakanishi K, Kawai T, Kumaki F, et al: Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Clin Cancer Res. 9:1105–1111. 2003.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chuang H, Chen C, Huang C, Fang F, Tsai H and Chien C: Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Exp Ther Med 2: 63-67, 2011.
APA
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., & Chien, C. (2011). Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Experimental and Therapeutic Medicine, 2, 63-67. https://doi.org/10.3892/etm.2010.168
MLA
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., Chien, C."Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma". Experimental and Therapeutic Medicine 2.1 (2011): 63-67.
Chicago
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., Chien, C."Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma". Experimental and Therapeutic Medicine 2, no. 1 (2011): 63-67. https://doi.org/10.3892/etm.2010.168
Copy and paste a formatted citation
x
Spandidos Publications style
Chuang H, Chen C, Huang C, Fang F, Tsai H and Chien C: Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Exp Ther Med 2: 63-67, 2011.
APA
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., & Chien, C. (2011). Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Experimental and Therapeutic Medicine, 2, 63-67. https://doi.org/10.3892/etm.2010.168
MLA
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., Chien, C."Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma". Experimental and Therapeutic Medicine 2.1 (2011): 63-67.
Chicago
Chuang, H., Chen, C., Huang, C., Fang, F., Tsai, H., Chien, C."Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma". Experimental and Therapeutic Medicine 2, no. 1 (2011): 63-67. https://doi.org/10.3892/etm.2010.168
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team