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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases

  • Authors:
    • Jun Li
    • Zhizhong Zhang
    • Gang Li
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology and Skin Science, University of British Columbia, Vancouver, B.C., Canada
  • Pages: 131-135
    |
    Published online on: December 2, 2010
       https://doi.org/10.3892/etm.2010.169
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Abstract

The application of biomarkers in melanoma prognosis has been well recognized. However the ability of a single biomarker to predict melanoma patient outcome is usually limited. We previously examined the expression of ten biomarkers (Bim, BRG1, BRMS1, CTHRC1, ING4, NQO1, NF-κB-p50, PUMA, SNF5 and SOX4) in melanomas. To assess the value of a combined multiple biomarker system in melanoma prognosis, we compared the expression of each biomarker between various stages of melanoma, and determined the best combination of biomarkers for melanoma prognosis. Although the expression of six biomarkers (Bim, BRMS1, ING4, NQO1, PUMA and SOX4) was significantly decreased in AJCC III-IV stages of melanoma compared to AJCC I-II stages, the combined 6-biomarker index score exhibited higher variations than any individual biomarker in the same comparison. Moreover, the 6-biomarker index score was correlated with melanoma thickness, location and subtype, and predicted the outcome of melanoma patients more accurately than the individual biomarkers. Multivariate Cox regression analysis demonstrated that the 6-biomarker index score is an independent prognostic factor for melanoma. In conclusion, our study suggests that a multi-biomarker system test is valuable for improved outcome prediction in melanoma patients and for the development of novel therapeutic strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Zhang Z and Li G: Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases. Exp Ther Med 2: 131-135, 2011.
APA
Li, J., Zhang, Z., & Li, G. (2011). Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases. Experimental and Therapeutic Medicine, 2, 131-135. https://doi.org/10.3892/etm.2010.169
MLA
Li, J., Zhang, Z., Li, G."Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases". Experimental and Therapeutic Medicine 2.1 (2011): 131-135.
Chicago
Li, J., Zhang, Z., Li, G."Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases". Experimental and Therapeutic Medicine 2, no. 1 (2011): 131-135. https://doi.org/10.3892/etm.2010.169
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhang Z and Li G: Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases. Exp Ther Med 2: 131-135, 2011.
APA
Li, J., Zhang, Z., & Li, G. (2011). Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases. Experimental and Therapeutic Medicine, 2, 131-135. https://doi.org/10.3892/etm.2010.169
MLA
Li, J., Zhang, Z., Li, G."Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases". Experimental and Therapeutic Medicine 2.1 (2011): 131-135.
Chicago
Li, J., Zhang, Z., Li, G."Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 cases". Experimental and Therapeutic Medicine 2, no. 1 (2011): 131-135. https://doi.org/10.3892/etm.2010.169
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