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Article

Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice

  • Authors:
    • Masakazu Tanaka
    • Takayuki Nitta
    • Binlian Sun
    • Jun-Ichi Fujisawa
    • Masanao Miwa
  • View Affiliations / Copyright

    Affiliations: Department of Genetics and Cell Biology, Graduate School of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan, Department of Microbiology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan
  • Pages: 89-93
    |
    Published online on: December 2, 2010
       https://doi.org/10.3892/etm.2010.179
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Abstract

Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia and HTLV-1-associated myelo-pathy/tropical spastic paraparesis. HTLV-1 is mainly transmitted through blood transfusion and breastfeeding, but viral proliferation in the body in vivo shortly after transmission is not well understood. To investigate whether the route of infection influences the early stages of viral proliferation, we inoculated BALB/c mice with MT-2 cells, an HTLV-1-producing human T-cell line, via different routes, and evaluated the proviral load and humoral immune responses. One month after infection, the provirus was detected in most organs of the mice infected intraperitoneally, and substantial proviral loads were detected in the peripheral blood and secondary lymphoid organs. In contrast, the mice infected intravenously and orally showed low proviral loads, and the provirus distribution was limited to the spinal cord among the intravenously inoculated mice and to the liver among the perorally inoculated mice. Mice infected intraperitoneally also exhibited higher interleukin-2 production than the mice infected intravenously or orally, or than the uninfected control mice, while anti-HTLV-1 antibody titers were comparable between the mice infected intraperitoneally and intravenously. These results demonstrate that the route of primary HTLV-1 infection influences the establishment of HTLV-1-infected cell proliferation and the cell reservoir in mice.
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1. 

Uchiyama T: Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol. 15:15–37. 1997. View Article : Google Scholar : PubMed/NCBI

2. 

Grant C, Barmak K, Alefantis T, Yao J, Jacobson S and Wigdahl B: Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation. J Cell Physiol. 190:133–159. 2002. View Article : Google Scholar

3. 

Okochi K, Sato H and Hinuma Y: A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang. 46:245–253. 1984. View Article : Google Scholar : PubMed/NCBI

4. 

Okayama A, Stuver S, Matsuoka M, Ishizaki J, Tanaka G, Kubuki Y, Mueller N, Hsieh CC, Tachibana N and Tsubouchi H: Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. Int J Cancer. 110:621–625. 1984. View Article : Google Scholar : PubMed/NCBI

5. 

Matsuzaki T, Nakagawa M, Nagai M, Usuku K, Higuchi I, Arimura K, Kubota H, Izumo S, Akiba S and Osame M: HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years. J Neurovirol. 7:228–234. 2001.PubMed/NCBI

6. 

Taylor GP, Tosswill JH, Matutes E, Daenke S, Hall S, Bain BJ, Davis R, Thomas D, Rossor M, Bangham CR and Weber JN: Prospective study of HTLVI infection in an initially asymptomatic cohort. J Acquir Immune Defic Syndr. 22:92–100. 1999. View Article : Google Scholar : PubMed/NCBI

7. 

Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO and Mueller NE: Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood. 92:3557–3561. 1998.PubMed/NCBI

8. 

Okayama A and Stuver SO: Long-term follow-up of HTLV-1 carriers. Gann Monogr Cancer Res. 50:127–139. 2003.

9. 

Nitta T, Tanaka M, Sun B, Hanai S and Miwa M: The genetic background as a determinant of human T-cell leukemia virus type 1 proviral load. Biochem Biophys Res Commun. 309:161–165. 2003. View Article : Google Scholar : PubMed/NCBI

10. 

Nitta T, Tanaka M, Sun B, Sugihara E, Kimura M, Kamada Y, Takahashi H, Hanai S, Jiang SW, Fujisawa J and Miwa M: Reduction of human T-cell leukemia virus type-1 infection in mice lacking nuclear factor-kappaB-inducing kinase. Cancer Sci. 99:872–878. 2008. View Article : Google Scholar : PubMed/NCBI

11. 

Tanaka M, Sun B, Fang J, Nitta T, Yoshida T, Kohtoh S, Kikukawa H, Hanai S, Uchida K and Miwa M: Human T-cell leukemia virus type 1 (HTLV-1) infection of mice: proliferation of cell clones with integrated HTLV-1 provirus in lymphoid organs. J Virol. 75:4420–4423. 2001. View Article : Google Scholar : PubMed/NCBI

12. 

Fang J, Kushida S, Feng R, Tanaka M, Kawamura T, Abe H, Maeda N, Onobori M, Hori M, Uchida K and Miwa M: Transmission of human T-cell leukemia virus type 1 to mice. J Virol. 72:3952–3957. 1998.PubMed/NCBI

13. 

Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K and Hinuma Y: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature. 294:770–771. 1981. View Article : Google Scholar : PubMed/NCBI

14. 

Kato H, Koya Y, Ohashi T, Hanabuchi S, Takemura F, Fujii M, Tsujimoto H, Hasegawa A and Kannagi M: Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats. J Virol. 72:7289–7293. 1998.PubMed/NCBI

15. 

Persaud D, Munoz JL, Tarsis SL, Parks ES and Parks WP: Time course and cytokine dependence of human T-cell lymphotropic virus type 1 T-lymphocyte transformation as revealed by a microtiter infectivity assay. J Virol. 69:6297–6303. 1995.

16. 

Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, Takara M, Matsuoka M, Yamaguchi K, Nakada K, Fujita K, Kojima S, Hori E, Tanaka Y, Kamihira S, Sato Y and Watanabe T: Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis. Oncogene. 21:2466–2475. 2002.PubMed/NCBI

17. 

Popovic M, Lange-Wantzin G, Sarin PS, Mann D and Gallo RC: Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci USA. 80:5402–5406. 1983. View Article : Google Scholar : PubMed/NCBI

18. 

Imada K, Takaori-Kondo A, Akagi T, Shimotohno K, Sugamura K, Hattori T, Yamabe H, Okuma M and Uchiyama T: Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo. Blood. 86:2350–2357. 1995.PubMed/NCBI

19. 

Ishihara S, Tachibana N, Okayama A, Murai K, Tsuda K and Mueller N: Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody. Jpn J Cancer Res. 83:320–323. 1992. View Article : Google Scholar : PubMed/NCBI

20. 

Lairmore MD, Silverman L and Ratner L: Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation. Oncogene. 24:6005–6015. 2005. View Article : Google Scholar : PubMed/NCBI

21. 

Dewan MZ, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M and Yamamoto N: Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. J Virol. 77:5286–5294. 2003. View Article : Google Scholar : PubMed/NCBI

22. 

Ohsugi T, Horie R, Kumasaka T, Ishida A, Ishida T, Yamaguchi K, Watanabe T, Umezawa K and Urano T: In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin in a mouse model of adult T-cell leukemia. Carcinogenesis. 26:1382–1388. 2005. View Article : Google Scholar : PubMed/NCBI

23. 

Simpson RM, Zhao TM, Schmidt HB, Said W and Kindt TJ: Source and route of exposure influence infectivity of a molecular clone of human T cell leukemia virus type I. AIDS Res Hum Retroviruses. 14:711–715. 1998. View Article : Google Scholar : PubMed/NCBI

24. 

Hasegawa A, Ohashi T, Hanabuchi S, Kato H, Takemura F, Masuda T and Kannagi M: Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response. J Virol. 77:2956–2963. 2003. View Article : Google Scholar : PubMed/NCBI

25. 

Jude BA, Pobezinskaya Y, Bishop J, Parke S, Medzhitov RM, Chervonsky AV and Golovkina TV: Subversion of the innate immune system by a retrovirus. Nat Immunol. 4:573–578. 2003. View Article : Google Scholar : PubMed/NCBI

26. 

Panoutsakopoulou V, Little CS, Sieck TG, Blankenhorn EP and Blank KJ: Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice. J Immunol. 161:17–26. 1998.PubMed/NCBI

27. 

Osame M, Janssen R, Kubota H, Nishitani H, Igata A, Nagataki S, Mori M, Goto I, Shimabukuro H and Khabbaz R: Nationwide survey of HTLV-1-associated myelopathy in Japan: association with blood transfusion. Ann Neurol. 28:50–56. 1990. View Article : Google Scholar : PubMed/NCBI

28. 

Jones KS, Akel S, Petrow-Sadowski C, Huang Y, Bertolette DC and Ruscetti FW: Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta. J Immunol. 174:4262–4270. 2005. View Article : Google Scholar : PubMed/NCBI

29. 

Moriuchi M and Moriuchi H: A milk protein lactoferrin enhances human T cell leukemia virus type I and suppresses HIV-1 infection. J Immunol. 166:4231–4236. 2001. View Article : Google Scholar : PubMed/NCBI

30. 

Moriuchi M and Moriuchi H: Transforming growth factor-beta enhances human T-cell leukemia virus type I infection. J Med Virol. 67:427–430. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tanaka M, Nitta T, Sun B, Fujisawa J and Miwa M: Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice. Exp Ther Med 2: 89-93, 2011.
APA
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., & Miwa, M. (2011). Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice. Experimental and Therapeutic Medicine, 2, 89-93. https://doi.org/10.3892/etm.2010.179
MLA
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., Miwa, M."Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice". Experimental and Therapeutic Medicine 2.1 (2011): 89-93.
Chicago
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., Miwa, M."Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice". Experimental and Therapeutic Medicine 2, no. 1 (2011): 89-93. https://doi.org/10.3892/etm.2010.179
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka M, Nitta T, Sun B, Fujisawa J and Miwa M: Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice. Exp Ther Med 2: 89-93, 2011.
APA
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., & Miwa, M. (2011). Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice. Experimental and Therapeutic Medicine, 2, 89-93. https://doi.org/10.3892/etm.2010.179
MLA
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., Miwa, M."Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice". Experimental and Therapeutic Medicine 2.1 (2011): 89-93.
Chicago
Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., Miwa, M."Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice". Experimental and Therapeutic Medicine 2, no. 1 (2011): 89-93. https://doi.org/10.3892/etm.2010.179
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