Metastasis tumour suppressor-1 and the aggressiveness of prostate cancer cells

Mustafa,Noha; Martin,Tracey  A.; Jiang,Wen  G.

doi:10.3892/etm.2010.184

January-February 2011 Volume 2 Issue 1

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January-February 2011 Volume 2 Issue 1

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Article

Metastasis tumour suppressor-1 and the aggressiveness of prostate cancer cells

Authors:
- Noha Mustafa
- Tracey A. Martin
- Wen G. Jiang
View Affiliations / Copyright

Affiliations: Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
Pages: 157-162
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Published online on: December 2, 2010

https://doi.org/10.3892/etm.2010.184
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Abstract

Previous studies have suggested that metastasis tumour suppressor-1 (MTSS1) plays a key role in cancer metastasis. Firstly, in this study we assessed MTSS1 expression levels in prostate cancer cell lines to reveal any changes in cell properties. Secondly, we aimed to clarify the cellular function of MTSS1 in prostate cancer cells. MTSS1 expression levels were assessed in different types of cancer cell lines through the RT-PCR analysis technique. The influence of MTSS1 was further examined via biological overexpression and knockdown in the prostate cancer cell lines. Two prostate cell lines were chosen for either knockdown or overexpression of the MTSS1 gene. The overexpression of MTSS1 in PC-3 human prostate cancer cells significantly suppressed the migratory, growth and adherence properties of the cells (p<0.01). By contrast, the knockdown of MTSS1 in DU-145 human prostate cancer cells dramatically enhanced these properties (p<0.001). We concluded that MTSS1 demonstrates the ability to play a role in controlling the metastatic nature of prostate cancer cells.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metastasis tumour suppressor-1 and the aggressiveness of prostate cancer cells

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