Association of SLC38A4 and system A with abnormal fetal birth weight

Li,Zhen; Lai,Guangrui; Deng,Lijun; Han,Yue; Zheng,Danfeng; Song,Weiwei

doi:10.3892/etm.2011.392

February 2012 Volume 3 Issue 2

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February 2012 Volume 3 Issue 2

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Article

Association of SLC38A4 and system A with abnormal fetal birth weight

Authors:
- Zhen Li
- Guangrui Lai
- Lijun Deng
- Yue Han
- Danfeng Zheng
- Weiwei Song
View Affiliations / Copyright

Affiliations: Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
Pages: 309-313
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Published online on: November 28, 2011

https://doi.org/10.3892/etm.2011.392
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Abstract

In this study, we aimed to explore the correlation between solute carrier family 38 member 4 (SLC38A4) and system A activity in human placentas from pregnancies with abnormal fetal birth weight. We collected placentas from consenting women immediately after their full-term babies were born, with normal, low birth weight or macrosomia, and used real-time PCR and Western blot analysis to detect the levels of SLC38A4 mRNA and protein [also known as sodium-coupled neutral amino acid transport protein 4 (SNAT4)]. Isotope incorporation assay was applied to measure system A activity in the placentas. Compared to the normal birth weight (NBW) group, placentas from the fetal macrosomia (FM) group had significantly increased levels of SLC38A4 mRNA and SNAT4 (both were increased by almost 2-fold; P<0.05), while no significant changes were detected in the placentas from the low birth weight (LBW) group. In addition, system A activity in the placentas from the FM and LBW groups was significantly different from that in the NBW group (1.2±0.20, 0.6±0.14 vs. 1.0±0.18, P<0.05). The data suggest that SNAT4 and system A have a strong association with abnormal fetal birth weight and that they may play a crucial role in fetal growth and development.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of SLC38A4 and system A with abnormal fetal birth weight

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Abstract

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