Increased susceptibility to ischemia-induced ventricular tachyarrhythmias in depressed rats: Involvement of reduction of connexin 43
- Authors:
- Wei Wu
- Yan Li
- Zhibing Lu
- Xiaorong Hu
View Affiliations
Affiliations: Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, P.R. China, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P.R. China
- Published online on: November 30, 2011 https://doi.org/10.3892/etm.2011.396
-
Pages:
192-194
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Abstract
Connexin 43 (Cx43) has been reported to contribute to the occurrence of ventricular arrhythmias during myocardial ischemia (MI). In this study, we investigated the expression of Cx43 and the incidences of ventricular tachyarrhythmias [i.e., ventricular tachycardia (VT) and ventricular fibrillation (VF)] during acute MI in chronic mild stress (CMS) in rats. Male Sprague-Dawley (SD) control and CMS rats were assigned into a sham operation (SO) group and a MI group. Ventricular tachyarrhythmias were assessed and Cx43 protein expression was measured by Western blotting. During 30-min ischemia, the incidences of VT (7/12, 58.3%) and VF (5/12, 41.7%) in the CMS-MI group were significantly decreased compared with those in the control-MI group (12/12, 100.0% and 11/12, 91.7%; P<0.05). The amount of total Cx43 of the CMS-SO group was significantly decreased to approximately 50% compared with that of the control-SO group (P<0.05). The 30-min ischemia did not result in a significant change in the amount of total Cx43 (total Cx43 is defined as the non-phosphorylated Cx43 and phosphorylated Cx43) compared to that of the SO group in CMS rats (P>0.05). The amount of non-phosphorylated Cx43 in the CMS-MI group was markedly increased compared to that of the CMS-SO group (P<0.05), suggesting that the relative amount of phosphorylated Cx43 was significantly decreased in CMS rats. The gap junctional permeability in the CMS-MI group (50.4±4.9%) was significantly decreased compared with the normal non‑ischemic value in the CMS-SO group (100%). The present study suggested that the incidence of ischemia‑induced ventricular tachyarrhythmias was markedly increased in depressed rats, which may be associated with the reduction of Cx43 protein expression in the ventricle of depressed rats.
View References
|
1.
|
K BoenglerR SchulzG HeuschConnexin 43
signalling and
cardioprotectionHeart9217241727200610.1136/hrt.2005.06687816387816
|
|
2.
|
WT Smith IVWF FleetTA JohnsonCL EngleWE
CascioThe Ib phase of ventricular arrhythmias in ischemic in situ
porcine heart is related to changes in cell-to-cell electrical
coupling. Experimental Cardiology Group, University of North
CarolinaCirculation9230513060199510.1161/01.CIR.92.10.3051
|
|
3.
|
JE SaffitzRB SchuesslerKA YamadaMechanisms
of remodeling of gap junction distributions and the development of
anatomic substrates of arrhythmiasCardiovasc
Res42309317199910.1016/S0008-6363(99)00023-110533569
|
|
4.
|
AJ GrippoCM SantosRF JohnsonTG BeltzJB
MartinsRB FelderAK JohnsonIncreased susceptibility to ventricular
arrhythmias in a rodent model of experimental depressionAm J
Physiol Heart Circ
Physiol286H619H626200410.1152/ajpheart.00450.200314715499
|
|
5.
|
W WuZ LuLoss of anti-arrhythmic effect of
vagal nerve stimulation on ischemia-induced ventricular
tachyarrhythmia in aged ratsTohoku J Exp
Med2232733201110.1620/tjem.223.2721187697
|
|
6.
|
R PappM GoncziM KovacsG SeprenyiA VeghGap
junctional uncoupling plays a trigger role in the antiarrhythmic
effect of ischaemic preconditioningCardiovasc
Res74396405200710.1016/j.cardiores.2007.02.02117362896
|
|
7.
|
SJ SchleiferMM Macari-HinsonDA CoyleWR
SlaterM KahnR GorlinHD ZuckerThe nature and course of depression
following myocardial infarctionArch Intern
Med14917851789198910.1001/archinte.1989.003900800590142788396
|
|
8.
|
DL LernerKA YamadaRB SchuesslerJE
SaffitzAccelerated onset and increased incidence of ventricular
arrhythmias induced by ischemia in Cx43-deficient
miceCirculation101547552200010.1161/01.CIR.101.5.54710662753
|
|
9.
|
DE GutsteinGE MorleyH TamaddonD VaidyaMD
SchneiderJ ChenKR ChienH StuhlmannGI FishmanConduction slowing and
sudden arrhythmic death in mice with cardiac-restricted
inactivation of connexin43Circ
Res88333339200110.1161/01.RES.88.3.33311179202
|
|
10.
|
M AndoRG KatareY KakinumaD ZhangF
YamasakiK MuramotoT SatoEfferent vagal nerve stimulation protects
heart against ischemia-induced arrhythmias by preserving connexin43
proteinCirculation112164170200510.1161/CIRCULATIONAHA.104.52549315998674
|
|
11.
|
H JiangX HuZ LuH WenD ZhaoQ TangB
YangEffects of sympathetic nerve stimulation on ischemia-induced
ventricular arrhythmias by modulating connexin43 in ratsArch Med
Res39647654200810.1016/j.arcmed.2008.07.00518760192
|
