Dan-Shen-Yin protects the heart against inflammation and oxidative stress induced by acute ischemic myocardial injury in rats

Yan,Kui-Po; Guo,Yong; Xing,Zhihua; Huang,Xi; Dai,Shengping; Duan,Min; Sun,Xinhua; Huang,Wei; Peng,Weijun

doi:10.3892/etm.2011.404

Dan-Shen-Yin protects the heart against inflammation and oxidative stress induced by acute ischemic myocardial injury in rats

Authors:
- Kui-Po Yan
- Yong Guo
- Zhihua Xing
- Xi Huang
- Shengping Dai
- Min Duan
- Xinhua Sun
- Wei Huang
- Weijun Peng
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Affiliations: Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Department of Cardiology, The PLA 152 Central Hospital, Pingdingshan 467000, P.R. China, Department of Cardiology, The First Affiliated Hospital of Henan College of TCM, Zhengzhou 450008, P.R. China
Published online on: December 5, 2011 https://doi.org/10.3892/etm.2011.404
Pages: 314-318

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Abstract

Dan-Shen-Yin (DSY) is a well-known traditional Chinese formula which is widely used in clinical practice for the treatment of coronary heart disease (CHD) and has produced a favorable effect in China. The present study was designed to examine whether or not acute oral DSY can protect the heart against myocardial infarction in acute myocardial ischemic rats. If so, we would then investigate the anti-inflammatory and anti-oxidant mechanisms involved. The left anterior descending coronary artery was occluded to induce myocardial ischemia in the hearts of Sprague-Dawley rats. At the end of the 3-h ischemic period (or 24 h for infarction size), we measured the myocardial infarction size, inflammatory factors and the activities of anti-oxidative enzymes. DSY reduced the infarction size and the serum levels of C-reactive protein, interleukin-6, tumour necrosis factor-α and malondialdehyde and increased the activities of superoxide dismutase and the serum levels of glutathione. The results show that DSY exerts signiﬁcant cardioprotective effects against acute ischemic myocardial injury in rats, possibly through its anti-inflammatory and anti-oxidant properties, and may thus be used as a potential therapeutic reagent for the treatment of CHD.

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