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Article

Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis

  • Authors:
    • Christiane Otto
    • Jenny Schkoldow
    • Elisabeth Krahl
    • Iris Fuchs
    • Hannes-Friedrich Ulbrich
  • View Affiliations / Copyright

    Affiliations: Therapeutic Research Group (TRG), Oncology and Gynecological Therapy, Bayer Pharma AG, Berlin 13342, Germany, Global Drug Discovery Statistics, Bayer Pharma AG, Berlin 13342, Germany
  • Pages: 410-414
    |
    Published online on: December 20, 2011
       https://doi.org/10.3892/etm.2011.425
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Abstract

Endometriosis is a chronic, estrogen-dependent disease characterized by the presence of ectopic endometrium either in the pelvic cavity (endometriosis externa) or within the uterus (endometriosis interna, adenomyosis). Key symptoms are pelvic pain, dysmenorrhea and infertility. Established rodent animal models used for drug research in endometriosis have certain limitations. Since rodents do not menstruate, they cannot develop endometriosis externa spontaneously, but they suffer from endometriosis interna. There is growing evidence that human endometriosis externa and interna represent two faces of the same disease. Both are estrogen-dependent and respond to similar treatment paradigms. Here, we addressed the question whether a murine endometriosis interna model may also be suitable for the characterization of drugs employed in human endometriosis. We examined the effects of danazol, Faslodex and cetrorelix in SHN mice that developed endometriosis interna after pituitary grafting. The GnRH antagonist cetrorelix and the estrogen receptor antagonist Faslodex, which negatively interfered with estrogen-mediated signaling, completely inhibited endometriosis interna, whereas danazol, an androgenic progestin, showed significant therapeutic activity in the majority of SHN mice. We conclude that this murine endometriosis interna model may be a valuable complement to established endometriosis externa models to support drug research in human endometriosis.
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1. 

G LeyendeckerM HerbertzG KunzG MallEndometriosis results from the dislocation of basal endometriumHum Reprod1727252736200210.1093/humrep/17.10.272512351554

2. 

J KitawakiN KadoH IshiharaH KoshibaY KitaokaH HonjoEndometriosis: the pathophysiology as an estrogen-dependent diseaseJ Steroid Biochem Mol Biol83149155200210.1016/S0960-0760(02)00260-112650711

3. 

G HalisS MechsnerAD EbertDiagnosis and treatment of deep infiltrating endometriosisDtsch Arztebl Int1074464552010

4. 

G BenagianoI BrosensS CarraraAdenomyosis: new knowledge is generating new treatment strategiesWomens Health5297311200919392615

5. 

JA SampsonPeritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavityAm J Obstet Gynecol14422469192719969738

6. 

G LeyendeckerL WildtG MallThe pathophysiology of endometriosis and adenomyosis: tissue injury and repairArch Gynecol Obstet280529538200910.1007/s00404-009-1191-019644696

7. 

L FedeleE SomiglianaG FrontinoL BenagliaP ViganoNew drugs in development for the treatment of endometriosisExpert Opin Investig Drugs1711871202200810.1517/13543784.17.8.118718616415

8. 

L StoryS KennedyAnimal studies in endometriosis: a reviewILAR J45132138200410.1093/ilar.45.2.13215111732

9. 

I Tirado-GonzalezG BarrientosN TariverdianPC ArckMG GarciaBF KlappSM BloisEndometriosis research: animal models for the study of a complex diseaseJ Reprod Immunol86141147201010.1016/j.jri.2010.05.00120594597

10. 

T MoriH NagasawaMechanism of development of prolactin-induced adenomyosis in miceActa Anat1164654198310.1159/0001457246858602

11. 

AK RodgersT FalconeTreatment strategies for endometriosisExpert Opin Pharmacother9243255200810.1517/14656566.9.2.243

12. 

T MoriM KyokuwaH NagasawaAnimal model of uterine adenomyosis: induction of the lesion in rats by ectopic pituitary isograftingLab Anim Sci48646819989517893

13. 

OJ DunnMultiple comparisons using rank sumsTechnometrics6241252196410.1080/00401706.1964.10490181

14. 

CW DunnettA multiple comparison procedure for comparing several treatments with a controlJ Am Statist Assoc5010961121195510.1080/01621459.1955.10501294

15. 

T SingtripopT MoriK ShiraishiMK ParkS KawashimaAge-related changes in gonadotrophin, prolactin and growth hormone levels with reference to the development of uterine adenomyosis in female SHN miceIn Vivo714715019938364165

16. 

R HusebyMJ SoaresF TalamantesEctopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinomasEndocrinology11614401448198510.1210/endo-116-4-14403971922

17. 

JF CouseMM YatesVR WalkerK KorachCharacterization of the hypothalamic pituitary-gonadal axis in estrogen receptor (ER) null mice reveals hypergonadism and endocrine sex reversal in females lacking ERα but not ERβMol Endocrinol1710391053200312624116

18. 

SW GuoDL OliveTwo unsuccessful clinical trials on endometriosis and a few lessons learnedGynecol Obstet Invest642435200710.1159/00009841317202821

19. 

T SingtripopT MoriS SakamotoS SassaMK ParkS KawashimaSuppression of the development of uterine adenomyosis by danazol treatment in miceLife Sci5111191125199210.1016/0024-3205(92)90513-O1518375

20. 

LC GiudiceLC KaoEndometriosisLancet36417891799200410.1016/S0140-6736(04)17403-515541453

21. 

R GruemmerAnimal models in endometriosis researchHum Reprod Update12641649200610.1093/humupd/dml02616775193

22. 

T MoriT SingtripopS KawashimaAnimal model of uterine adenomyosis: is prolactin a potent inducer of adenomyosis in mice?Am J Obstet Gynecol165232234199110.1016/0002-9378(91)90258-S1853904

23. 

T MoriH NagasawaS TakahashiThe induction of adenomyosis in mice by intrauterine pituitary isograftsLife Sci2912771282198110.1016/0024-3205(81)90234-47300555

24. 

P VercelliniE SomiglianaP VaganoA AbbiatiG BarbaraPG CrosignaniEndometriosis – current therapies and new pharmacological developmentsDrugs696496752009

25. 

Z FangS YangJP LydonF DeMayoM TamuraB GuratesSE BulunIntact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosisFertil Steril82673678200410.1016/j.fertnstert.2004.01.048

26. 

SE BulunYH ChengP YinG ImirH UtsunomiyaE AttarJ InnesKJ JulieProgesterone resistance in endometriosis: link to failure to metabolize estradiolMol Cell Endocrinol24894103200610.1016/j.mce.2005.11.04116406281

27. 

L FedeleS BianchiG FrontinoHormonal treatment for adenomyosisBest Pract Res Clin Obstet Gynaecol22333339200810.1016/j.bpobgyn.2007.07.00617765017

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Copy and paste a formatted citation
Spandidos Publications style
Otto C, Schkoldow J, Krahl E, Fuchs I and Ulbrich H: Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis. Exp Ther Med 3: 410-414, 2012.
APA
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., & Ulbrich, H. (2012). Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis. Experimental and Therapeutic Medicine, 3, 410-414. https://doi.org/10.3892/etm.2011.425
MLA
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., Ulbrich, H."Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis". Experimental and Therapeutic Medicine 3.3 (2012): 410-414.
Chicago
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., Ulbrich, H."Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis". Experimental and Therapeutic Medicine 3, no. 3 (2012): 410-414. https://doi.org/10.3892/etm.2011.425
Copy and paste a formatted citation
x
Spandidos Publications style
Otto C, Schkoldow J, Krahl E, Fuchs I and Ulbrich H: Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis. Exp Ther Med 3: 410-414, 2012.
APA
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., & Ulbrich, H. (2012). Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis. Experimental and Therapeutic Medicine, 3, 410-414. https://doi.org/10.3892/etm.2011.425
MLA
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., Ulbrich, H."Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis". Experimental and Therapeutic Medicine 3.3 (2012): 410-414.
Chicago
Otto, C., Schkoldow, J., Krahl, E., Fuchs, I., Ulbrich, H."Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis". Experimental and Therapeutic Medicine 3, no. 3 (2012): 410-414. https://doi.org/10.3892/etm.2011.425
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