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Article

Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats

  • Authors:
    • Fan He
    • Fang Qu
    • Fulin Song
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shenyang Northern Hospital, Shenyang 110016, P.R. China, Department of Pathology, Shenyang Northern Hospital, Shenyang 110016, P.R. China
  • Pages: 613-616
    |
    Published online on: January 12, 2012
       https://doi.org/10.3892/etm.2012.450
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Abstract

Neuregulin 1 (NGR1) and survivin have been shown to be neuroprotective. However, the link between their expression and aspirin in the treatment of cerebral ischemia remains unclear. Here, we investigated the effect of aspirin on NGR1 and survivin expression after focal cerebral ischemia/reperfusion in rats. Sprague Dawley rats were randomly divided into an aspirin treatment group (n=40) and a control group (n=40). Each group was further divided into five subgroups according to the time after reperfusion. A middle cerebral artery model was established by an occlusion suture. At 24 h, 3, 5 and 7 days after reperfusion, the Bederson neurological deficit scores were 1.47±0.11, 1.22±0.08, 0.85±0.15 and 0.59±0.12 in the treatment group, and 1.87±0.18, 1.45±0.14, 1.05±0.08 and 0.75±0.15 in the control group, respectively, indicating a significant difference at each time point (P<0.05). In the infarct center, the number of NGR1- and survivin-positive cells reached the maximum at 6 h and decreased gradually to a minimum at 7 days, while in the peri-infarct area, the number was few at 6 h, peaked at 3 days and then was reduced gradually with significant differences between the two time points (P<0.05). There were more NGR1- and survivin-positive cells in the treatment group compared to the control group (P<0.05). In conclusion, the neuroprotective effect of aspirin is at least partly mediated by the upregulation of NGR1 and survivin expression after ischemia.
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Copy and paste a formatted citation
Spandidos Publications style
He F, Qu F and Song F: Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats. Exp Ther Med 3: 613-616, 2012.
APA
He, F., Qu, F., & Song, F. (2012). Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats. Experimental and Therapeutic Medicine, 3, 613-616. https://doi.org/10.3892/etm.2012.450
MLA
He, F., Qu, F., Song, F."Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats". Experimental and Therapeutic Medicine 3.4 (2012): 613-616.
Chicago
He, F., Qu, F., Song, F."Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats". Experimental and Therapeutic Medicine 3, no. 4 (2012): 613-616. https://doi.org/10.3892/etm.2012.450
Copy and paste a formatted citation
x
Spandidos Publications style
He F, Qu F and Song F: Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats. Exp Ther Med 3: 613-616, 2012.
APA
He, F., Qu, F., & Song, F. (2012). Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats. Experimental and Therapeutic Medicine, 3, 613-616. https://doi.org/10.3892/etm.2012.450
MLA
He, F., Qu, F., Song, F."Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats". Experimental and Therapeutic Medicine 3.4 (2012): 613-616.
Chicago
He, F., Qu, F., Song, F."Aspirin upregulates the expression of neuregulin 1 and survivin after focal cerebral ischemia/reperfusion in rats". Experimental and Therapeutic Medicine 3, no. 4 (2012): 613-616. https://doi.org/10.3892/etm.2012.450
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