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Article

Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry

  • Authors:
    • Jing Li
    • Guang-Zhi Yang
    • Zi-Man Zhu
    • Zhi-Yong Zhou
    • Lin Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, the General Hospital of Beijing Military Command, Beijing 100700, P.R. China, Department of Surgery, The 304th Hospital of PLA, Beijing 100037, P.R. China, Department of Gastroenterology, The 306th Hospital of PLA, Beijing 100101, P.R. China
  • Pages: 621-624
    |
    Published online on: January 30, 2012
       https://doi.org/10.3892/etm.2012.465
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Abstract

Osteopontin (OPN), a secreted phosphorylated glycoprotein, has been found to be involved in carcinogenesis, progression and metastasis of several types of cancers. The aim of the present study was to investigate the immunohistochemical expression of OPN in colorectal carcinoma (CRC) and its relationship with clinicopathological parameters and P53. Expression of OPN, Ki-67 and TP53 was detected in 77 cases of CRC by immunohistochemistry and the correlation of the expression of OPN with clinicopathological features, Ki-67 and P53 staining was investigated. Thirty-eight cases (49.4%) of CRC demonstrated OPN overexpression. Overexpression of OPN was associated with lymph node metastasis (P=0.025) and Dukes' stages (P=0.031), but not with gender, histological differentiation, depth of tumor invasion, TNM stages or Ki-67 index. The correlation between expression of OPN and TP53 was statistically significant (P=0.030). In conclusion, OPN is overexpressed in CRC, and plays a role in tumor progression and metastasis, which is possibly regulated by P53.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Yang G, Zhu Z, Zhou Z and Li L: Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Exp Ther Med 3: 621-624, 2012.
APA
Li, J., Yang, G., Zhu, Z., Zhou, Z., & Li, L. (2012). Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Experimental and Therapeutic Medicine, 3, 621-624. https://doi.org/10.3892/etm.2012.465
MLA
Li, J., Yang, G., Zhu, Z., Zhou, Z., Li, L."Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry". Experimental and Therapeutic Medicine 3.4 (2012): 621-624.
Chicago
Li, J., Yang, G., Zhu, Z., Zhou, Z., Li, L."Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry". Experimental and Therapeutic Medicine 3, no. 4 (2012): 621-624. https://doi.org/10.3892/etm.2012.465
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Yang G, Zhu Z, Zhou Z and Li L: Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Exp Ther Med 3: 621-624, 2012.
APA
Li, J., Yang, G., Zhu, Z., Zhou, Z., & Li, L. (2012). Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. Experimental and Therapeutic Medicine, 3, 621-624. https://doi.org/10.3892/etm.2012.465
MLA
Li, J., Yang, G., Zhu, Z., Zhou, Z., Li, L."Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry". Experimental and Therapeutic Medicine 3.4 (2012): 621-624.
Chicago
Li, J., Yang, G., Zhu, Z., Zhou, Z., Li, L."Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry". Experimental and Therapeutic Medicine 3, no. 4 (2012): 621-624. https://doi.org/10.3892/etm.2012.465
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