Potent anti-inflammatory agent escin does not affect the healing of tibia fracture and abdominal wound in an animal model

Zhang,Leiming; Wang,Hongsheng; Wang,Tian; Jiang,Na; Yu,Pengfei; Liu,Feiyan; Chong,Yating; Fu,Fenghua

doi:10.3892/etm.2012.467

Potent anti-inflammatory agent escin does not affect the healing of tibia fracture and abdominal wound in an animal model

Authors:
- Leiming Zhang
- Hongsheng Wang
- Tian Wang
- Na Jiang
- Pengfei Yu
- Feiyan Liu
- Yating Chong
- Fenghua Fu
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Affiliations: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China
Published online on: January 31, 2012 https://doi.org/10.3892/etm.2012.467
Pages: 735-739

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Abstract

Escin, a potent anti-inflammatory and anti-edematous agent, has been widely used clinically in preventing inflammatory edema after trauma, such as fracture and surgery. The aim of this study was to investigate whether escin has an inhibitory effect on fracture healing, and whether escin has an inhibitory effect on wound healing after surgery. Male New Zealand white rabbits underwent tibial mid-diaphyseal osteotomy, and were administered escin once per day for 10 days. At weeks 2, 4 and 6, bone fracture healing and bone mineral density were measured. The histologic examination of callus, osteocalcin, alkaline phosphatase, calcium and phosphate in the serum were also assayed. In another experiment, the rats underwent midline laparotomy, and received escin once prior to or after the operation. Six days later, the abdominal incision wounds were excised for measuring hydroxyproline levels. The results showed that there were no significant differences in fracture healing between the model and rabbits administered escin, and escin did not affect the hydroxyproline levels in the abdominal incision wounds of the rats. These findings suggest that escin has no inhibitory effect on fracture and wound healing in animal models.

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