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Article

Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer

  • Authors:
    • Wei Zhang
    • Jiezhong Wang
    • Mingdeng Tang
    • Jianji Pan
    • Penggang Bai
    • Duanyu Lin
    • Feiyu Qian
    • Fengjie Lin
    • Xueqin Yang
    • Shengli Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Fujian Provincial Cancer Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350014, P.R. China, Department of Nuclear Medicine, Fujian Provincial Cancer Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350014, P.R. China, No. 2 Clinical Medical School of Wuhan University, Wuhan, Hubei 430071, P.R. China, School of Management at Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China
  • Pages: 631-635
    |
    Published online on: January 31, 2012
       https://doi.org/10.3892/etm.2012.468
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Abstract

Radiation lung injury is a common side‑effect of pulmonary radiotherapy. The aim of this study was to quantitatively assess early changes in lung perfusion single photon emission computed tomography (SPECT) scanning and pulmonary function testing (PFT) prior to and after intensity modulated radiotherapy (IMRT) for patients suffering from locally advanced non-small cell lung cancer (LANSCLC). Twenty patients with LANSCLC received lung perfusion SPECT scanning and PFT prior to IMRT and immediately after IMRT. Lung perfusion index (LPI) was calculated after the quantification of perfusion SPECT images. The LPI of the two groups was analyzed by matched t-test. The radioactive count of each layer of single lung was added to obtain the sum of the irradiated area. The percentage of the irradiated area of single lung was calculated. Linear correlation analysis was carried out between the percentage of the irradiated area and LPI in order to verify the validity of LPI. In this study, LPI and the percentage of the irradiated area of single lung exhibited an excellent correlation either prior to or after IMRT (r=0.820 and r=0.823, respectively; p<0.001). There was no statistically significant difference between pre-IMRT LPI and post-IMRT LPI (p=0.135). LPI in the group receiving a radical dose had no statistically significant difference (p=0.993), however, it showed a statistically significant difference in the group receiving a non-radical dose (p=0.025). In the non-radical dose group, the post-IMRT LPI was larger compared to pre-IMRT. None of the parameters of PFT exhibited a statistically significant difference prior to and after IMRT (p>0.05). The quantitative method of lung perfusion SPECT scanning can be used to evaluate changes in perfusion early in patients receiving a non-radical dose (BED ≤126,500 cGy) IMRT. Evaluating early changes in global lung function using the current method of PFT is difficult, since time can be a contributing factor for radiation-induced lung injury.
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1. 

Mehta V: Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys. 63:5–24. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Marks LB, Yu X, Vujaskovic Z, et al: Radiation-induced lung injury. Semin Radiat Oncol. 13:333–345. 2003. View Article : Google Scholar : PubMed/NCBI

3. 

Murshed H, Liu HH, Liao Z, et al: Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 58:1258–1267. 2004.PubMed/NCBI

4. 

Sura S, Gupta V, Yorke E, et al: Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience. Radiother Oncol. 87:17–23. 2008. View Article : Google Scholar : PubMed/NCBI

5. 

Yom SS, Liao Z, Liu HH, et al: Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 68:94–102. 2007. View Article : Google Scholar

6. 

Graves PR, Siddiqui F, Anscher MS, et al: Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol. 20:201–207. 2010. View Article : Google Scholar : PubMed/NCBI

7. 

Ghafoori P, Marks LB, Vujaskovic Z, et al: Radiation-induced lung injury. Assessment, management, and prevention. Oncology (Williston Park). 22:37–47. 2008.PubMed/NCBI

8. 

Spyropoulou D, Leotsinidis M, Tsiamita M, et al: Pulmonary function testing in women with breast cancer treated with radiotherapy and chemotherapy. In Vivo. 23:867–872. 2009.PubMed/NCBI

9. 

Allen AM, Henning GT, Ten Haken RK, et al: Do dose-volume metrics predict pulmonary function changes in lung irradiation? Int J Radiat Oncol Biol Phys. 55:921–929. 2003.PubMed/NCBI

10. 

De Jaeger K, Seppenwoolde Y, Boersma LJ, et al: Pulmonary function following high-dose radiotherapy of non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 55:1331–1340. 2003.PubMed/NCBI

11. 

Miller KL, Zhou SM, Barrier RC Jr, et al: Long-term changes in pulmonary function tests after definitive radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys. 56:611–615. 2003. View Article : Google Scholar : PubMed/NCBI

12. 

Theuws JC, Kwa SL, Wagenaar AC, et al: Dose-effect relations for early local pulmonary injury after irradiation for malignant lymphoma and breast cancer. Radiother Oncol. 48:33–43. 1998. View Article : Google Scholar : PubMed/NCBI

13. 

Kim S, Kim HK, Kang DY, et al: Intra-operative sentinel lymph node identification using a novel receptor-binding agent (technetium-99m neomannosyl human serum albumin, 99mTc-MSA) in stage I non-small cell lung cancer. Eur J Cardiothorac Surg. 37:1450–1456. 2010. View Article : Google Scholar

14. 

Zhang WJ, Zheng R, Zhao LJ, et al: Utility of SPECT lung perfusion scans in assessing early changes in pulmonary function of patients with lung cancer after radiotherapy. Ai Zheng. 23:1180–1184. 2004.PubMed/NCBI

15. 

Ahn BC, Kim HJ, Lee SW, et al: New quantitative method for bone tracer uptake of temporomandibular joint using Tc-99m MDP skull SPECT. Ann Nucl Med. 23:651–656. 2009. View Article : Google Scholar : PubMed/NCBI

16. 

Munley MT, Marks LB, Hardenbergh PH, et al: Functional imaging of normal tissues with nuclear medicine: applications in radiotherapy. Semin Radiat Oncol. 11:28–36. 2001. View Article : Google Scholar : PubMed/NCBI

17. 

Curran WJ Jr, Moldofsky PJ and Solin LJ: Observations on the predictive value of perfusion lung scans on post-irradiation pulmonary function among 210 patients with bronchogenic carcinoma. Int J Radiat Oncol Biol Phys. 24:31–36. 1992. View Article : Google Scholar

18. 

Boersma LJ, Damen EM, de Boer RW, et al: Estimation of overall pulmonary function after irradiation using dose-effect relations for local functional injury. Radiother Oncol. 36:15–23. 1995. View Article : Google Scholar

19. 

Miller KL, Shafman TD, Anscher MS, et al: Bronchial stenosis: an underreported complication of high-dose external beam radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys. 61:64–69. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Marks LB, Munley MT, Spencer DP, et al: Quantification of radiation-induced regional lung injury with perfusion imaging. Int J Radiat Oncol Biol Phys. 38:399–409. 1997. View Article : Google Scholar : PubMed/NCBI

21. 

Zhang J, Ma J, Zhou S, et al: Radiation-induced reductions in regional lung perfusion: 0.1-12 year data from a prospective clinical study. Int J Radiat Oncol Biol Phys. 76:425–432. 2010.PubMed/NCBI

22. 

Kong FM, Frey KA, Quint LE, et al: A pilot study of [18F]fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer. J Clin Oncol. 25:3116–3123. 2007.

23. 

Theuws JC, Seppenwoolde Y, Kwa SL, et al: Changes in local pulmonary injury up to 48 months after irradiation for lymphoma and breast cancer. Int J Radiat Oncol Biol Phys. 47:1201–1208. 2000. View Article : Google Scholar : PubMed/NCBI

24. 

Woel RT, Munley MT, Hollis D, et al: The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up. Int J Radiat Oncol Biol Phys. 52:58–67. 2002.PubMed/NCBI

25. 

Marks LB, Hollis D, Munley M, et al: The role of lung perfusion imaging in predicting the direction of radiation-induced changes in pulmonary function tests. Cancer. 88:2135–2141. 2000. View Article : Google Scholar : PubMed/NCBI

26. 

Fan M, Marks LB, Lind P, et al: Relating radiation-induced regional lung injury to changes in pulmonary function tests. Int J Radiat Oncol Biol Phys. 51:311–317. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Wang J, Tang M, Pan J, Bai P, Lin D, Qian F, Lin F, Yang X, Zhang S, Zhang S, et al: Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer. Exp Ther Med 3: 631-635, 2012.
APA
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D. ... Zhang, S. (2012). Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 631-635. https://doi.org/10.3892/etm.2012.468
MLA
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D., Qian, F., Lin, F., Yang, X., Zhang, S."Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 3.4 (2012): 631-635.
Chicago
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D., Qian, F., Lin, F., Yang, X., Zhang, S."Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 4 (2012): 631-635. https://doi.org/10.3892/etm.2012.468
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Wang J, Tang M, Pan J, Bai P, Lin D, Qian F, Lin F, Yang X, Zhang S, Zhang S, et al: Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer. Exp Ther Med 3: 631-635, 2012.
APA
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D. ... Zhang, S. (2012). Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 631-635. https://doi.org/10.3892/etm.2012.468
MLA
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D., Qian, F., Lin, F., Yang, X., Zhang, S."Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 3.4 (2012): 631-635.
Chicago
Zhang, W., Wang, J., Tang, M., Pan, J., Bai, P., Lin, D., Qian, F., Lin, F., Yang, X., Zhang, S."Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 4 (2012): 631-635. https://doi.org/10.3892/etm.2012.468
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