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Article

Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors

  • Authors:
    • Satoko Ebina
    • Takako Chiba
    • Takashi Ozaki
    • Ikuo Kashiwakura
  • View Affiliations / Copyright

    Affiliations: Department of Disability and Health, Hirosaki University Graduate School of Health Sciences, Hirosaki 036-8564, Japan, Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki 036-8564, Japan, Department of Obstetrics and Gynecology, Hirosaki National Hospital, Hirosaki 036-8545, Japan
  • Pages: 387-390
    |
    Published online on: June 20, 2012
       https://doi.org/10.3892/etm.2012.617
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Abstract

Oxidative stress is associated with the development of various diseases including cancer, arteriosclerosis, diabetes mellitus, hypertension and metabolic syndrome. However, little is known about the involvement of 8-hydroxydeoxyguanosine (8-OHdG) during the perinatal period. At present, few studies have investigated the precise correlations between 8-OHdG levels in cord blood (CB) and the physical conditions of the mother and neonate. To clarify the involvement of 8-OHdG during the perinatal period, the relationships between CB 8-OHdG levels and maternal/neonatal characteristics in vaginal deliveries were determined. The 8-OHdG levels of CB units collected from singleton gestation vaginal deliveries were analyzed. The relationships between 8-OHdG levels and perinatal characteristics were analyzed. The 8-OHdG levels in CB ranged from 0.1 to 1.39 ng/ml (median, 0.37 ng/ml). The relationships between 8-OHdG levels and the perinatal data were analyzed. The 8-OHdG levels detected in the non-smoking group were significantly lower compared to those in the smoking group. However, no significant correlation was observed between 8-OHdG levels and other maternal/neonatal factors, including umbilical artery acid/base and gas values. Maternal smoking increases the level of the oxidative DNA damage biomarker 8-OHdG in CB. Since oxidative stress may influence the long-term health outcomes of infants after birth, understanding maternal and fetus/neonate stress conditions at delivery may help improve the health of fetuses and infants.
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Copy and paste a formatted citation
Spandidos Publications style
Ebina S, Chiba T, Ozaki T and Kashiwakura I: Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors. Exp Ther Med 4: 387-390, 2012.
APA
Ebina, S., Chiba, T., Ozaki, T., & Kashiwakura, I. (2012). Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors. Experimental and Therapeutic Medicine, 4, 387-390. https://doi.org/10.3892/etm.2012.617
MLA
Ebina, S., Chiba, T., Ozaki, T., Kashiwakura, I."Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors". Experimental and Therapeutic Medicine 4.3 (2012): 387-390.
Chicago
Ebina, S., Chiba, T., Ozaki, T., Kashiwakura, I."Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors". Experimental and Therapeutic Medicine 4, no. 3 (2012): 387-390. https://doi.org/10.3892/etm.2012.617
Copy and paste a formatted citation
x
Spandidos Publications style
Ebina S, Chiba T, Ozaki T and Kashiwakura I: Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors. Exp Ther Med 4: 387-390, 2012.
APA
Ebina, S., Chiba, T., Ozaki, T., & Kashiwakura, I. (2012). Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors. Experimental and Therapeutic Medicine, 4, 387-390. https://doi.org/10.3892/etm.2012.617
MLA
Ebina, S., Chiba, T., Ozaki, T., Kashiwakura, I."Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors". Experimental and Therapeutic Medicine 4.3 (2012): 387-390.
Chicago
Ebina, S., Chiba, T., Ozaki, T., Kashiwakura, I."Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors". Experimental and Therapeutic Medicine 4, no. 3 (2012): 387-390. https://doi.org/10.3892/etm.2012.617
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