Endothelin B receptors exert antipruritic effects via peripheral κ-opioid receptors

  • Authors:
    • Wenjin Ji
    • Jiexian Liang
    • Zhiwei Zhang
  • View Affiliations

  • Published online on: June 27, 2012     https://doi.org/10.3892/etm.2012.624
  • Pages: 503-506
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Abstract

Endothelin B receptor agonists exert antipruritic effects on itching induced via endothelin-1 (ET-1) and compound 48/80. Peripheral µ- and κ-opioid receptors (MORs and KORs, respectively) are reported to be involved in the antinociceptive properties triggered by ETB agonists. Therefore, we investigated the role of peripheral opioid receptors in the scratching response induced by ET-1. ETA and ETB antagonists and non-selective and selective opioid receptor antagonists were co-injected with ET-1 in the neck of mice and the number of scratching bouts was counted. Pretreatment with systemically administered naloxone significantly reduced the number of scratches, while co-injection of naloxone substantially augmented the effect of ET-1. Co-injection of nor‑Binaltorphimine (nor-BNI), a KOR antagonist, significantly increased the number of scratches induced by ET-1. However, CTOP (a MOR antagonist) and naltrindole [a δ-opioid receptor (DOR) antagonist] did not alter the scratching response elicited by ET-1. These results indicate that peripheral KORs mediate the antipruritic effect of endothelin B receptor activation.
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September 2012
Volume 4 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ji W, Liang J and Zhang Z: Endothelin B receptors exert antipruritic effects via peripheral κ-opioid receptors. Exp Ther Med 4: 503-506, 2012
APA
Ji, W., Liang, J., & Zhang, Z. (2012). Endothelin B receptors exert antipruritic effects via peripheral κ-opioid receptors. Experimental and Therapeutic Medicine, 4, 503-506. https://doi.org/10.3892/etm.2012.624
MLA
Ji, W., Liang, J., Zhang, Z."Endothelin B receptors exert antipruritic effects via peripheral κ-opioid receptors". Experimental and Therapeutic Medicine 4.3 (2012): 503-506.
Chicago
Ji, W., Liang, J., Zhang, Z."Endothelin B receptors exert antipruritic effects via peripheral κ-opioid receptors". Experimental and Therapeutic Medicine 4, no. 3 (2012): 503-506. https://doi.org/10.3892/etm.2012.624