Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October 2012 Volume 4 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 2012 Volume 4 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer

  • Authors:
    • Bengul Gunalp
    • Semra Ince
    • Alper Ozgur Karacalioglu
    • Asli Ayan
    • Ozdes Emer
    • Engin Alagoz
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Gulhane Military Medical Academy and Faculty, 06018 Ankara, Turkey
  • Pages: 693-698
    |
    Published online on: August 9, 2012
       https://doi.org/10.3892/etm.2012.659
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of this study was to determine the clinical significance of 18F-FDG PET/CT on initial staging and therapy planning in patients with invasive breast cancer. One hundred and forty-one consecutive, biopsy proven preoperative and 195 postoperative high-risk breast cancer patients who were referred for PET/CT for initial staging were included in this retrospective study. The clinical stage had been determined by conventional imaging modalities prior to the PET/CT scan. Of the 141 examined preoperative patients, 19 had clinical stage I (T1N0), 51 had stage IIA (12 T2N0 and 39 T1N1), 49 had stage IIB (2 T3N0 and 47 T2N1), 12 had stage IIIA (11 T3N1, 1 T2N2), 2 had stage IIIB (2 T4N1) and 8 had stage IV. PET/CT modified the staging for 26% of stage I patients, 29% of stage IIA patients, 46% of stage IIB patients, 58% of stage IIIA patients and 100% of stage IIIB patients. PET/CT scans detected extra-axillary regional lymph nodes in 14 (9.9%) patients and distant metastasis in 41 (29%) patients. PET/CT scans detected multifocal lesions in 30 (21%) patients, multicentric lesions in 21 (14%) patients and malign foci in the contralateral breast (bilateral breast cancer) confirmed by biopsy in 5 (3.5%) patients. Of the examined 195 postoperative patients PET/CT detected axillary lymph nodes in 22 (11%) patients, extra‑axillary regional lymph nodes in 21 (10%) patients and distant metastasis in 24 (12%) patients. PET/CT findings altered plans for radiotherapy in 22 (11%) patients and chemotherapy was adapted to the metastatic diseases in 24 (12%) patients. PET/CT was revealed to be superior to conventional imaging modalities for the detection of extra-axillary regional metastatic lymph nodes and distant metastases. These features make PET/CT an essential imaging modality for the primary staging of invasive breast cancer, particularly in patients with clinical stages II and III.
View Figures

Figure 1

View References

1 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar

2 

Esserman L: Integration of imaging in the management of breast cancer. J Clin Oncol. 23:1601–1602. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Groheux D, Giaccchetti S, Espié M, et al: The yield of 18F-FDG PET/CT in patients with clinical stage IIA, IIB, or IIIA breast cancer: a prospective study. J Nucl M. 52:1526–1534. 2011.

4 

Groheux D, Moretti J, Baillet G, et al: Effect of 18F-FDG PET/CT imaging in patients with clinical stage II and III breast cancer. Int J Radiat Oncol Biol Phys. 71:695–704. 2008.

5 

Heusner TA, Kuemmel S, Umutlu L, et al: Breast cancer staging in a single session: whole-body PET/CT mammography. J Nucl Med. 49:1215–1222. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Fuster D, Duch J, Paredes P, et al: Preoperative staging of large primary breast cancer with [18F] fluorodeoxyglucose positron emission tomography/computed tomography compared with conventional imaging procedures. J Clin Oncol. 26:4746–4751. 2008.

7 

Aukema TS, Straver ME, Peeters MJ, et al: Detection of extra-axillary lymph node involvement with FDG PET/CT in patients with stage II–III breast cancer. Eur J Cancer. 46:3205–3210. 2010.PubMed/NCBI

8 

Segaert I, Mottaghy F, Ceyssens S, et al: Additional value of PET-CT in staging of clinical stage IIB and III breast cancer. Breast J. 16:617–624. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual (7th edition). Springer. New York: 2010.

10 

Nakamoto Y, Cohade C, Tatsumi M, Hammoud D and Wahl RL: CT appearance of bone metastases detected with FDG PET as part of the same PET/CT examination. Radiology. 237:627–634. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Quon A and Gambhir SS: FDG-PET and beyond: molecular breast cancer imaging. J Clin Oncol. 23:1664–1673. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Heusner TA, Kuemmel S, Hahn S, et al: Diagnostic value of full-dose FDG-PET/CT for axillary lymph node staging in breast cancer patients. Eur J Nucl Med Mol Imaging. 36:1543–1550. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Groheux D, Hindié E, Rubello D, et al: Should FDG PET/CT be used for initial staging of breast cancer? Eur J Nucl Med Mol Imaging. 36:1539–1542. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lee JH, Rosen EL and Mankoff DA: The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1 – overview, detection, and staging. J Nucl Med. 50:569–581. 2009.

15 

Yang WT, Le-Petross HT, Macapinlac H, et al: Inflammatory breast cancer: PET/CT, MRI, mammography, and sonography findings. Breast Cancer Res Treat. 109:417–426. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Carkaci S, Macapinlac HA, Cristofanilli M, et al: Retrospective study of 18F FDG PET/CT in the diagnosis of inflammatory breast cancer: preliminary data. J Nucl Med. 50:231–238. 2009.

17 

Kuru B, Camlibel M, Dinc S, Gulcelik MA and Alagol H: Prognostic significance of axillary node and infraclavicular lymph node status after mastectomy. Eur J Surg Oncol. 29:839–844. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Brito RA, Valero V, Buzdar AU, et al: Long-term results of combined-modality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases: The University of Texas M.D. Anderson Cancer Center experience. J Clin Oncol. 19:628–633. 2001.

19 

Cermik TF, Mavi A, Basu S and Alavi A: Impact of FDG PET on the preoperative staging of newly diagnosed breast cancer. Eur J Nucl Med Mol Imaging. 35:475–483. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Port ER, Yeung H, Gonen M, et al: 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography scanning affects surgical management in selected patients with high-risk, operable breast carcinoma. Ann Surg Oncol. 13:677–684. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Mahner S, Schirrmacher S, Brenner W, et al: Comparison between positron emission tomography using 2-[fluorine-18] fluoro-2-deoxy-D-glucose, conventional imaging and computed tomography for staging of breast cancer. Ann Oncol. 19:1249–1254. 2008.

22 

Nakai T, Okuyama C, Kubota T, et al: Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer. Eur J Nucl Med Mol Imaging. 32:1253–1258. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gunalp B, Ince S, Karacalioglu AO, Ayan A, Emer O and Alagoz E: Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer. Exp Ther Med 4: 693-698, 2012.
APA
Gunalp, B., Ince, S., Karacalioglu, A.O., Ayan, A., Emer, O., & Alagoz, E. (2012). Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer. Experimental and Therapeutic Medicine, 4, 693-698. https://doi.org/10.3892/etm.2012.659
MLA
Gunalp, B., Ince, S., Karacalioglu, A. O., Ayan, A., Emer, O., Alagoz, E."Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer". Experimental and Therapeutic Medicine 4.4 (2012): 693-698.
Chicago
Gunalp, B., Ince, S., Karacalioglu, A. O., Ayan, A., Emer, O., Alagoz, E."Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer". Experimental and Therapeutic Medicine 4, no. 4 (2012): 693-698. https://doi.org/10.3892/etm.2012.659
Copy and paste a formatted citation
x
Spandidos Publications style
Gunalp B, Ince S, Karacalioglu AO, Ayan A, Emer O and Alagoz E: Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer. Exp Ther Med 4: 693-698, 2012.
APA
Gunalp, B., Ince, S., Karacalioglu, A.O., Ayan, A., Emer, O., & Alagoz, E. (2012). Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer. Experimental and Therapeutic Medicine, 4, 693-698. https://doi.org/10.3892/etm.2012.659
MLA
Gunalp, B., Ince, S., Karacalioglu, A. O., Ayan, A., Emer, O., Alagoz, E."Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer". Experimental and Therapeutic Medicine 4.4 (2012): 693-698.
Chicago
Gunalp, B., Ince, S., Karacalioglu, A. O., Ayan, A., Emer, O., Alagoz, E."Clinical impact of 18F-FDG PET/CT on initial staging and therapy planning for breast cancer". Experimental and Therapeutic Medicine 4, no. 4 (2012): 693-698. https://doi.org/10.3892/etm.2012.659
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team