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Article

Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism

  • Authors:
    • Jing-Mei Zhong
    • Shao-Yuan Wu
    • Jie Bai
    • Qiang Guo
    • Jian Tao
    • Hui Chen
    • Nai-Wei Zhao
    • Zhong Zhao
    • Hao Fu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First People's Hospital of Yunnan, Kunhua Affiliated Hospital of Kunming Medical University, Kunming 650032, P.R. China, Medical Faculty, Kunming University of Science and Technology, Kunming 650500, P.R. China
  • Pages: 627-632
    |
    Published online on: August 16, 2012
       https://doi.org/10.3892/etm.2012.669
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Abstract

Depression is a highly debilitating and widely distributed illness in the general population. Geranylgeranylacetone (GGA), a non-toxic anti-ulcer drug, has been reported to have protective effects in the central nervous system. The aim of this study was to determine the antidepressant effect of GGA in a chronic mild stress (CMS) model of depression. We confirmed that CMS in rats caused a reduction in locomotor activity and an increase in the levels of monoamine oxidase-A (MAO-A) and caspase-3 in the hippocampus. GGA treatment reversed stress-induced alterations in locomotor activity and target levels of MAO-A and caspase-3. In addition, GGA treatment induced heat shock protein 70 (Hsp70) expression in the hippocampus. These findings suggest that GGA possesses an antidepressant activity in a CMS model of depression. The activity of GGA in the relief of depression may be mediated via the induction of Hsp70 expression to suppress MAO-A expression and the apoptosis cascade.
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Copy and paste a formatted citation
Spandidos Publications style
Zhong J, Wu S, Bai J, Guo Q, Tao J, Chen H, Zhao N, Zhao Z and Fu H: Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism . Exp Ther Med 4: 627-632, 2012.
APA
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H. ... Fu, H. (2012). Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism . Experimental and Therapeutic Medicine, 4, 627-632. https://doi.org/10.3892/etm.2012.669
MLA
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H., Zhao, N., Zhao, Z., Fu, H."Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism ". Experimental and Therapeutic Medicine 4.4 (2012): 627-632.
Chicago
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H., Zhao, N., Zhao, Z., Fu, H."Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism ". Experimental and Therapeutic Medicine 4, no. 4 (2012): 627-632. https://doi.org/10.3892/etm.2012.669
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong J, Wu S, Bai J, Guo Q, Tao J, Chen H, Zhao N, Zhao Z and Fu H: Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism . Exp Ther Med 4: 627-632, 2012.
APA
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H. ... Fu, H. (2012). Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism . Experimental and Therapeutic Medicine, 4, 627-632. https://doi.org/10.3892/etm.2012.669
MLA
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H., Zhao, N., Zhao, Z., Fu, H."Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism ". Experimental and Therapeutic Medicine 4.4 (2012): 627-632.
Chicago
Zhong, J., Wu, S., Bai, J., Guo, Q., Tao, J., Chen, H., Zhao, N., Zhao, Z., Fu, H."Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism ". Experimental and Therapeutic Medicine 4, no. 4 (2012): 627-632. https://doi.org/10.3892/etm.2012.669
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