Chronic kidney disease in patients with ileal conduit urinary diversion

Naganuma,Toshihide; Takemoto,Yoshiaki; Maeda,Satoshi; Iwai,Tomoaki; Kuwabara,Nobuyuki; Shoji,Tetsuo; Okamura,Mikio; Nakatani,Tatsuya

doi:10.3892/etm.2012.703

December 2012 Volume 4 Issue 6

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December 2012 Volume 4 Issue 6

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Article

Chronic kidney disease in patients with ileal conduit urinary diversion

Authors:
- Toshihide Naganuma
- Yoshiaki Takemoto
- Satoshi Maeda
- Tomoaki Iwai
- Nobuyuki Kuwabara
- Tetsuo Shoji
- Mikio Okamura
- Tatsuya Nakatani
View Affiliations / Copyright

Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan, Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan, Department of Nephrology, Ohno Memorial Hospital, Osaka, Japan
Pages: 962-966
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Published online on: September 11, 2012

https://doi.org/10.3892/etm.2012.703
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Abstract

While renal dysfunction is often observed in patients following urinary diversion due to bladder cancer, there have been few studies on this subject. A cross‑sectional study was performed on the renal function of ileal conduit urinary diversion patients and the prevalence and risk factors for chronic kidney disease (CKD) were examined. Patients with ileal conduit urinary diversion (n=102), who were being followed-up as outpatients and who were in stable condition, as well as age‑ and gender‑matched healthy control subjects (n=63) were selected for this study. The prevalence of CKD was compared between the patients and healthy subjects. Next, the clinical factors associated with the presence of CKD were investigated in the patients with ileal conduit diversion using logistic regression analysis. The prevalence of CKD was significantly higher in the patients with ileal conduit diversion compared with the healthy subjects [60 patients (58.8%) vs. 11 healthy subjects (17.5%), P<0.0001]. The mean decrease in the estimated glomerular filtration rate per year of the patients with urinary diversion was 0.95±2.0 ml/min/1.73 m2. Multiple logistic regression analysis revealed that the independent and significant factors associated with the presence of CKD were older age and the presence of hypertension, urolithiasis and a past history of hydronephrosis. In conclusion, an increased prevalence of CKD was revealed in the patients with ileal conduit urinary diversion, suggesting the need for better management of hypertension, urolithiasis and hydronephrosis following surgery.

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1	Madersbacher S, Schmidt J, Eberle JM, et al: Long-term outcome of ileal conduit diversion. J Urol. 169:985–990. 2003. View Article : Google Scholar : PubMed/NCBI
2	Neal DE: Complications of ileal conduit diversion in adults with cancer followed up for at least five years. Br Med J (Clin Res Ed). 290:1695–1697. 1985.PubMed/NCBI
3	Singh G, Wilkinson JM and Thomas DG: Supravesical diversion for incontinence: a long-term follow-up. Br J Urol. 79:348–353. 1997. View Article : Google Scholar : PubMed/NCBI
4	Sullivan JW, Grabstald H and Whitmore WF Jr: Complications of ureteroileal conduit with radical cystectomy: review of 336 cases. J Urol. 124:797–801. 1980.PubMed/NCBI
5	Shimko MS, Tollefson MK, Umbreit EC, Farmer SA, Blute ML and Frank I: Long-term complications of conduit urinary diversion. J Urol. 185:562–567. 2011. View Article : Google Scholar : PubMed/NCBI
6	Foley RN, Murray AM, Li S, et al: Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999. J Am Soc Nephrol. 16:489–495. 2005. View Article : Google Scholar : PubMed/NCBI
7	Go AS, Chertow GM, Fan D, McCulloch CE and Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 351:1296–1305. 2004. View Article : Google Scholar : PubMed/NCBI
8	Sarnak MJ, Levey AS, Schoolwerth AC, et al: Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 108:2154–2169. 2003. View Article : Google Scholar
9	Shlipak MG, Sarnak MJ, Katz R, et al: Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 352:2049–2060. 2005. View Article : Google Scholar : PubMed/NCBI
10	Koch MO, McDougal WS, Hall MC, Hill DE, Braren HV and Donofrio MN: Long-term metabolic effects of urinary diversion: a comparison of myelomeningocele patients managed by clean intermittent catheterization and urinary diversion. J Urol. 147:1343–1347. 1992.
11	Matsuo S, Imai E, Horio M, et al: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992. 2009. View Article : Google Scholar : PubMed/NCBI
12	Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 20:1183–1197. 1997. View Article : Google Scholar : PubMed/NCBI
13	Imai E, Horio M, Watanabe T, et al: Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol. 13:621–630. 2009. View Article : Google Scholar : PubMed/NCBI
14	Imai E, Horio M, Yamagata K, et al: Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study. Hypertens Res. 31:433–441. 2008.PubMed/NCBI
15	Chen N, Wang W, Huang Y, et al: Community-based study on CKD subjects and the associated risk factors. Nephrol Dial Transplant. 24:2117–2123. 2009. View Article : Google Scholar : PubMed/NCBI
16	Shulman NB, Ford CE, Hall WD, et al: Prognostic value of serum creatinine and effect of treatment of hypertension on renal function. Results from the hypertension detection and follow-up program The Hypertension Detection and Follow-up Program Cooperative Group. Hypertension. 13:I80–I93. 1989. View Article : Google Scholar
17	Walker WG, Neaton JD, Cutler JA, Neuwirth R and Cohen JD: Renal function change in hypertensive members of the Multiple Risk Factor Intervention Trial. Racial and treatment effects The MRFIT Research Group. JAMA. 268:3085–3091. 1992. View Article : Google Scholar
18	Rule AD, Bergstralh EJ, Melton LJ 3rd, Li X, Weaver AL and Lieske JC: Kidney stones and the risk for chronic kidney disease. Clin J Am Soc Nephrol. 4:804–811. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Chronic kidney disease in patients with ileal conduit urinary diversion

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