Number of metastasis-positive lymph node stations is a simple and reliable prognostic factor following surgery in patients with esophageal cancer

Takeno,Shinsuke; Yamashita,Shin-Ichi; Yamamoto,Satoshi; Takahashi,Yoshiaki; Moroga,Toshihiko; Kawahara,Katsunobu; Shiroshita,Toyoo; Yamana,Ippei; Maki,Kenji; Yamashita,Yuichi

doi:10.3892/etm.2012.705

December 2012 Volume 4 Issue 6

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December 2012 Volume 4 Issue 6

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Article

Number of metastasis-positive lymph node stations is a simple and reliable prognostic factor following surgery in patients with esophageal cancer

Authors:
- Shinsuke Takeno
- Shin-Ichi Yamashita
- Satoshi Yamamoto
- Yoshiaki Takahashi
- Toshihiko Moroga
- Katsunobu Kawahara
- Toyoo Shiroshita
- Ippei Yamana
- Kenji Maki
- Yuichi Yamashita
View Affiliations / Copyright

Affiliations: Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, Fukuoka City, Fukuoka, Japan, Department of Surgery II, Oita University Faculty of Medicine, Oita, Japan
Pages: 1087-1091
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Published online on: September 13, 2012

https://doi.org/10.3892/etm.2012.705
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Abstract

The aim of this study was to evaluate the utility of lymph node metastasis classification based on the number of positive stations in patients undergoing surgical management of esophageal cancer. Of 257 patients who underwent curative esophagectomy, 126 patients with lymph node involvement underwent assessment of nodal metastasis mode according to the 7th edition of the TNM classification (UICC), and the Japanese Guidelines for the Clinical and Pathological Studies on Carcinoma of the Esophagus. Lymph node metastasis mode was divided into single station (S) and multi-station (M) groups. The S group was subclassified into single-node-single-station (SS) or multi-node-single-station (MS), and the M group was subclassified into multi-station in pN1 (2 metastasis positive nodes; MM-pN1) or multi-station in pN2 or 3 (MM-pN2,3) by TNM classification, multi-station-single-area (MMS) or multi-station-multi-areas (MMM). The correlation between prognosis and lymph node metastasis mode was assessed. A total of 47 patients were classified as S (MS, n=11; SS, n=36), and 79 patients were classified as M (MM-pN1, n=12; MM-pN2,3, n=67; MMM, n=55; MMS, n=24). Prognosis was poorer among the M- than in the S-classified patients (p=0.0035), whereas prognosis was not significantly different between the subgroups. In conclusion, lymph node metastasis classification based on the number of metastasis-positive stations is a useful predictor of prognosis in patients undergoing surgical management of esophageal cancer. This system relies on a simple classification method that combines the Japanese classification based on lymphatic spread and the TNM classification based on the number of positive lymph nodes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Number of metastasis-positive lymph node stations is a simple and reliable prognostic factor following surgery in patients with esophageal cancer

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