Comparative study of thyroid puncture biopsy guided by contrast-enhanced ultrasonography and conventional ultrasound

Li,Fengsheng; Luo,Huiting

doi:10.3892/etm.2013.1016

Comparative study of thyroid puncture biopsy guided by contrast-enhanced ultrasonography and conventional ultrasound

Authors:
- Fengsheng Li
- Huiting Luo
View Affiliations

Affiliations: Department of Ultrasound, Shaanxi Provincial Cancer Hospital Affiliated to Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Ultrasound, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712000, P.R. China
Published online on: March 15, 2013 https://doi.org/10.3892/etm.2013.1016
Pages: 1381-1384

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of this study was to investigate the application value of thyroid puncture biopsy guided by contrast‑enhanced ultrasound (CEUS). A total of 48 patients with 51 solid thyroid nodules (suspected papillary thyroid carcinoma, PTC) were enrolled in the study. Following detection by conventional ultrasonography and CEUS, puncture biopsy of the suspicious lesions guided by conventional ultrasonography and CEUS was conducted, respectively. Then, pathological diagnosis was performed. The number of PTC positive nodules and puncture points detected by the two methods were compared. In 51 nodules with 310 punctures, 44 nodules (86.3%, 44/51) and 240 punctures (77.4%, 240/310) were pathologically diagnosed as PTC. In the 44 nodules diagnosed as PTC, 43 and 34 nodules were detected by CEUS and conventional ultrasound, respectively, with a significant difference between the two methods (P=0.022). Eleven (25%) nodules were independently detected by CEUS. The sensitivity and accuracy of puncture point detection by CEUS (82.9 and 82.6%, respectively) were significantly higher compared with those of conventional ultrasound (48.3 and 56.5%, respectively; P<0.001). The specificity of puncture points detected by CEUS (81.4%) was significantly lower compared with that by conventional ultrasound (84.3%; P=0.009). Compared with conventional ultrasound, a greater number of PTC-positive nodules were detected by CEUS, with increased sensitivity and accuracy of the puncture points.

View Figures

View References

1.	Solbiati L, Livraghi T, Ballarati E, Ierace T and Crespi L: Tumors of the follicular epithelium. Ultrasound of Superficial Structures. Solbiati L and Rizzatto G: Churchill Livingstone; New York: pp. 63–71. 1995
2.	Hamazaki N, Kounoike Y, Suzaki Y, et al: Usefulness of color Doppler sonography in the diagnosis of thyroid nodules: comparison of velocity mode with power mode. Jpn J Med Ultrason. 24:873–877. 1997.
3.	Tae HJ, Lim DJ, Baek KH, et al: Diagnostic value of ultrasonography to distinguish between benign and malignant lesions in the management of thyroid nodules. Thyroid. 17:461–466. 2007. View Article : Google Scholar : PubMed/NCBI
4.	Frates MC, Benson CB, Charboneau JW, et al: Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 237:794–800. 2005. View Article : Google Scholar
5.	Cappelli C, Pirola I, Cumetti D, et al: Is the anteroposterior and transverse diameter ratio of nonpalpable thyroid nodules a sonographic criteria for recommending fine-needle aspiration cytology? Clin Endocrinol (Oxf). 63:689–693. 2005. View Article : Google Scholar
6.	Roy C, Buy X, Lang H, et al: Contrast enhanced color Doppler endorectal sonography of prostate: efficiency for detecting peripheral zone tumors and role for biopsy procedure. J Urol. 170:69–72. 2003. View Article : Google Scholar : PubMed/NCBI
7.	Halpern EJ, Rosenberg M and Gomella LG: Prostate cancer: contrast-enhanced US for detection. Radiology. 219:219–225. 2001. View Article : Google Scholar : PubMed/NCBI
8.	Halpern EJ, Verkh L, Forsberg F, Gomella LG, Mattrey RF and Goldberg BB: Initial experience with contrast-enhanced sonography of the prostate. AJR Am J Roentgenol. 174:1575–1580. 2000. View Article : Google Scholar : PubMed/NCBI
9.	Bartolotta TV, Midiri M, Galia M, et al: Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: initial results. Eur Radiol. 16:2234–2241. 2006. View Article : Google Scholar : PubMed/NCBI
10.	Kettenbach J, Helbich TH, Huber S, Zuna I and Dock W: Computer-assisted quantitative assessment of power Doppler US: effects of microbubble contrast agent in the differentiation of breast tumors. Eur J Radiol. 53:238–244. 2005. View Article : Google Scholar : PubMed/NCBI
11.	Davies L and Welch HG: Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 295:2164–2167. 2006.
12.	Lin JD, Kuo SF, Chao TC and Hsueh C: Incidental and nonincidental papillary thyroid microcarcinoma. Ann Surg Oncol. 15:2287–2292. 2008. View Article : Google Scholar : PubMed/NCBI
13.	Grodski S and Delbridge L: An update on papillary microcarcinoma. Curr Opin Oncol. 21:1–4. 2009. View Article : Google Scholar : PubMed/NCBI
14.	Besic N, Pilko G, Petric R, Hocevar M and Zgajnar J: Papillary thyroid microcarcinoma: prognostic factors and treatment. J Surg Oncol. 97:221–225. 2008. View Article : Google Scholar : PubMed/NCBI
15.	Chung YS, Kim JY, Bae JS, et al: Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid. 19:241–246. 2009. View Article : Google Scholar : PubMed/NCBI
16.	Lim YC, Choi EC, Yoon YH, Kim EH and Koo BS: Central lymph node metastases in unilateral papillary thyroid microcarcinoma. Br J Surg. 96:253–257. 2009. View Article : Google Scholar : PubMed/NCBI
17.	Galiè M, D’Onofrio M, Montani M, et al: Tumor vessel compression hinders perfusion of ultrasonography contrast agents. Neoplasia. 7:528–536. 2005.PubMed/NCBI
18.	Mehrotra P, Viswanathan H, Johnson SJ, Wadehra V, Richardson DL and Lennard TW: Ultrasound guidance improves the adequacy of our preoperative thyroid cytology but not its accuracy. Cytopathology. 17:137–144. 2006. View Article : Google Scholar : PubMed/NCBI
19.	Braga M, Cavalcanti TC, Collaco LM and Graf H: Efficacy of ultrasound-guided fine-needle aspiration biopsy in the diagnosis of complex thyroid nodules. J Clin Endocrinol Metab. 86:4089–4091. 2001. View Article : Google Scholar : PubMed/NCBI
20.	Quinn SF, Nelson HA and Demlow TA: Thyroid biopsies: fine-needle aspiration biopsy versus spring-activated core biopsy needle in 102 patients. J Vasc Interv Radiol. 5:619–623. 1994. View Article : Google Scholar : PubMed/NCBI