The association between metabolic syndrome and vascular endothelial dysfunction in adolescents

  • Authors:
    • Ying Wei
    • Geli Liu
    • Jingyan Yang
    • Rongxiu Zheng
    • Lihong Jiang
    • Pengli Bao
  • View Affiliations

  • Published online on: April 9, 2013     https://doi.org/10.3892/etm.2013.1055
  • Pages: 1663-1666
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Abstract

The aim of this study was to investigate the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in adolescents. Sixty obese pediatric inpatients at the General Hospital of Tianjin Medical University from February 2011 to February 2012 were included. Among these, 30 patients were obese and 30 patients were diagnosed with MS. Thirty healthy subjects were randomly selected as the control group. A series of indices, including height, body weight, waist circumference, hip circumference, waist/hip circumference and body mass index (BMI), as well as total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were evaluated. von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) levels were determined using an enzyme linked immunosorbent assay (ELISA). Correlation analysis between height, body weight, waist circumference, hip circumference, waist/hip circumference, BMI, TC, TG, LDL, HDL and PAI-1, as well as vWF was performed. Significant increases of vWF and PAI-1 levels were observed in the MS group compared with the control group (P<0.05). For the adolescents in the obese group, a significant increase of PAI-1 level was observed compared with the control group (P<0.05). No significant difference was observed between the vWF levels in the obese and control groups. PAI-1 was positively associated with BMI, waist circumference, waist/hip circumference, TC, TG, LDL, fasting plasma glucose (FPG), fasting insulin (FINS), systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively (P<0.05). In addition, PAI-1 was negatively associated with HDL levels (P<0.05). PAI-1 and vWF may be used as biomarkers for the diagnosis of ECD. ECD in individuals with MS may be associated with obesity, blood fat, blood sugar and blood pressure. FPG, TC and TG may be risk factors for ECD.
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June 2013
Volume 5 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wei Y, Liu G, Yang J, Zheng R, Jiang L and Bao P: The association between metabolic syndrome and vascular endothelial dysfunction in adolescents. Exp Ther Med 5: 1663-1666, 2013.
APA
Wei, Y., Liu, G., Yang, J., Zheng, R., Jiang, L., & Bao, P. (2013). The association between metabolic syndrome and vascular endothelial dysfunction in adolescents. Experimental and Therapeutic Medicine, 5, 1663-1666. https://doi.org/10.3892/etm.2013.1055
MLA
Wei, Y., Liu, G., Yang, J., Zheng, R., Jiang, L., Bao, P."The association between metabolic syndrome and vascular endothelial dysfunction in adolescents". Experimental and Therapeutic Medicine 5.6 (2013): 1663-1666.
Chicago
Wei, Y., Liu, G., Yang, J., Zheng, R., Jiang, L., Bao, P."The association between metabolic syndrome and vascular endothelial dysfunction in adolescents". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1663-1666. https://doi.org/10.3892/etm.2013.1055