Renoprotective activity of sivelestat in severe acute pancreatitis in rats

Wang,Houhong; Tang,A-Mao; Liu,Daren; Li,Guogang; Ye,Longyun; Li,Xiaowen; Li,Chao; Chen,Li

doi:10.3892/etm.2013.1075

July 2013 Volume 6 Issue 1

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July 2013 Volume 6 Issue 1

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Article

Renoprotective activity of sivelestat in severe acute pancreatitis in rats

Authors:
- Houhong Wang
- A-Mao Tang
- Daren Liu
- Guogang Li
- Longyun Ye
- Xiaowen Li
- Chao Li
- Li Chen
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Affiliations: Department of Surgery, Zhejiang University School of Medicine, Second Affiliated Hospital, Hangzhou, Zhejiang 310009, P.R. China, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310053, P.R. China
Pages: 29-32
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Published online on: April 24, 2013

https://doi.org/10.3892/etm.2013.1075
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Abstract

Acute pancreatitis, affecting 382,014 individuals annually in China, is life-threatening in its severe form. Since acute pancreatitis-associated morbidity or mortality is attributable mainly to functional failure of the vital organs, significant research efforts have focused on the identification of novel agents with potential organ-protective properties in the hope of developing approaches to improve the outcome of acute pancreatitis. In a previous study, we demonstrated that sivelestat, a specific inhibitor of neutrophil elastase (NE), is effective in protecting against lung failure in rats with taurocholate-induced acute pancreatitis. As part of the analyses extended from that study, the present study aimed to evaluate the role of sivelestat in the protection against acute pancreatitis-associated renal injury. Renal histopathology and major renal function parameters were analyzed in renal tissue and blood specimens collected from rats with acute pancreatitis induced by the surgical administration of sodium taurocholate in the presence or absence of sivelestat treatment and in sham-operated control rats at various time‑points. The extended analyses demonstrated that: i) sodium taurocholate induced apparent renal injury and dysfunction manifested by histological anomalies, including vacuolization and apoptosis of the cells of the tubular epithelial lining in the kidney, as well as biochemical aberrations in the blood (increases in levels of blood urea nitrogen, creatinine and tumor necrosis factor-α) and renal tissue (robust increases in NE activity and induced neutrophil chemoattractant-1 levels); and ii) sivelestat treatment effectively attenuated all taurocholate-induced histological anomalies and biochemical aberrations. These observations strongly suggest that the NE inhibitor, sivelestat, is effective in protecting against acute pancreatitis-associated renal injury.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Renoprotective activity of sivelestat in severe acute pancreatitis in rats

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