Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July 2013 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2013 Volume 6 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases

  • Authors:
    • Jianda Zhou
    • Jinyan Liu
    • Chengqun Luo
    • Feng Hu
    • Rui Liu
    • Zizi Chen
    • Yao Chen
    • Wu Xiong
    • Jianfei Xie
    • Quanyong He
    • Chaoqi Yin
    • Shaohua Wang
    • Yanwen Zhang
    • Sainan Zeng
  • View Affiliations / Copyright

    Affiliations: The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 223-227
    |
    Published online on: April 29, 2013
       https://doi.org/10.3892/etm.2013.1081
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to explore the etiology and diagnosis of multiple intracranial hemorrhages (ICHs) following severe burns, with a retrospective review of 16 cases of severe burns further complicated by multiple ICHs. Using cranial CT scans of the brains, we identified that all patients presented with low platelet counts and coagulation abnormalities prior to intracranial hemorrhaging. Following conventional treatment and various supporting treatments, five cases succumbed following a progressive reduction in blood platelet levels and the ICHs were cured in 11 cases following the restoration of normal platelet levels. We conclude that low platelet counts and coagulation abnormalities may cause multiple ICHs following severe burns and early diagnosis and treatment is the key to successful treatment.
View Figures

Figure 1

Figure 2

View References

1. 

Fu Y, Xie B, Ben D, et al: Pathogenic alteration in severe burn wounds. Burns. 38:90–94. 2012. View Article : Google Scholar : PubMed/NCBI

2. 

Kushner D: Mild traumatic brain injury: toward understanding manifestations and treatment. Arch Intern Med. 158:1617–1624. 1998. View Article : Google Scholar : PubMed/NCBI

3. 

Zhu H, Li F, Zou M, et al: Experimental high-altitude intracerebral hemorrhage in minipigs: histology, behavior and itracranial pressure in a double-injection model. Acta Neurochir (Wien). 155:655–661. 2013. View Article : Google Scholar

4. 

Lee J, Evans CS, Singh N, et al: Head computed tomography utilization and intracranial hemorrhage rates. Emerg Radiol. Dec 19–2012.(Epub ahead of print).

5. 

Hart DW, Wolf SE, Mlcak R, et al: Persistence of muscle catabolism after severe burn. Surgery. 128:312–319. 2000. View Article : Google Scholar : PubMed/NCBI

6. 

Gauglitz GG, Herndon DN, Kulp GA, Meyer WJ III and Jeschke MG: Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J Clin Endocrinol Metab. 94:1656–1664. 2009.PubMed/NCBI

7. 

Jeschke MG, Chinkes DL, Finnerty CC, et al: Pathophysiologic response to severe burn injury. Ann Surg. 248:387–401. 2008.PubMed/NCBI

8. 

Cho SJ, Minn YK and Kwon KH: Stroke after burn. Cerebrovasc Dis. 24:261–263. 2007. View Article : Google Scholar : PubMed/NCBI

9. 

Winkelman MD and Galloway PG: Central nervous system complications of thermal burns. A postmortem study of 139 patients. Medicine (Baltimore). 71:271–283. 1992. View Article : Google Scholar : PubMed/NCBI

10. 

Huisse MG, Pease S, Hurtado-Nedelec M, et al: Leukocyte activation: The link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris. Crit Care Med. 36:2288–2295. 2008. View Article : Google Scholar : PubMed/NCBI

11. 

Marshall JC: Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med. 29:S99–S106. 2001. View Article : Google Scholar : PubMed/NCBI

12. 

Schouten M, Wiersinga WJ, Levi M and van der Poll T: Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 83:536–545. 2008. View Article : Google Scholar : PubMed/NCBI

13. 

Pawlinski R, Pedersen B, Erlich J and Mackman N: Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: Lessons from low tissue factor mice. Thromb Haemost. 92:444–450. 2004.PubMed/NCBI

14. 

Cho SJ, Minn YK and Kwon KH: Stroke after burn. Cerebrovasc Dis. 24:261–263. 2007. View Article : Google Scholar : PubMed/NCBI

15. 

Xie HQ, Zhou JD, Nie XM, et al: HSP70 inhibits burn serum-induced apoptosis of cardiomyocytes via mitochondrial and membrane death receptor pathways. J Burn Care Res. 29:512–518. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Murray CK, Loo FL, Hospenthal DR, et al: Incidence of systemic fungal infection and related mortality following severe burns. Burns. 34:1108–1112. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Cox RA, Mlcak RP, Chinkes DL, et al: Upper airway mucus deposition in lung tissue of burn trauma victims. Shock. 29:356–361. 2008.PubMed/NCBI

18. 

Rosanova M, Epelbaum C, Noman A, et al: Use of colistin in a pediatric burn unit in Argentina. J Burn Care Res. 30:612–615. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Liu J, Luo C, Hu F, Liu R, Chen Z, Chen Y, Xiong W, Xie J, He Q, He Q, et al: Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases. Exp Ther Med 6: 223-227, 2013.
APA
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z. ... Zeng, S. (2013). Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases. Experimental and Therapeutic Medicine, 6, 223-227. https://doi.org/10.3892/etm.2013.1081
MLA
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z., Chen, Y., Xiong, W., Xie, J., He, Q., Yin, C., Wang, S., Zhang, Y., Zeng, S."Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases". Experimental and Therapeutic Medicine 6.1 (2013): 223-227.
Chicago
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z., Chen, Y., Xiong, W., Xie, J., He, Q., Yin, C., Wang, S., Zhang, Y., Zeng, S."Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases". Experimental and Therapeutic Medicine 6, no. 1 (2013): 223-227. https://doi.org/10.3892/etm.2013.1081
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Liu J, Luo C, Hu F, Liu R, Chen Z, Chen Y, Xiong W, Xie J, He Q, He Q, et al: Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases. Exp Ther Med 6: 223-227, 2013.
APA
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z. ... Zeng, S. (2013). Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases. Experimental and Therapeutic Medicine, 6, 223-227. https://doi.org/10.3892/etm.2013.1081
MLA
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z., Chen, Y., Xiong, W., Xie, J., He, Q., Yin, C., Wang, S., Zhang, Y., Zeng, S."Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases". Experimental and Therapeutic Medicine 6.1 (2013): 223-227.
Chicago
Zhou, J., Liu, J., Luo, C., Hu, F., Liu, R., Chen, Z., Chen, Y., Xiong, W., Xie, J., He, Q., Yin, C., Wang, S., Zhang, Y., Zeng, S."Thrombocytopenia induces multiple intracranial hemorrhages in patients with severe burns: A review of 16 cases". Experimental and Therapeutic Medicine 6, no. 1 (2013): 223-227. https://doi.org/10.3892/etm.2013.1081
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team