Expression and correlation of Twist and gelatinases in breast cancer

Zhao,Min; Hu,Hong-Guang; Huang,Jin; Zou,Qiang; Wang,Jin; Liu,Ming-Qiang; Zhao,Yang; Li,Gui-Zhu; Xue,Song; Wu,Zheng-Sheng

doi:10.3892/etm.2013.1099

Expression and correlation of Twist and gelatinases in breast cancer

Authors:
- Min Zhao
- Hong-Guang Hu
- Jin Huang
- Qiang Zou
- Jin Wang
- Ming-Qiang Liu
- Yang Zhao
- Gui-Zhu Li
- Song Xue
- Zheng-Sheng Wu
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Affiliations: Department of Pathology, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China, Department of Pathology, The First People's Hospital of Huainan, Huainan, Anhui 232007, P.R. China, Department of Pathology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
Published online on: May 2, 2013 https://doi.org/10.3892/etm.2013.1099
Pages: 97-100

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Abstract

Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases. The association of Twist and gelatinase expression with clinicopathological factors and patient survival was analyzed. Altered expression of Twist, MMP-2 and MMP-9 proteins was observed in breast cancer tissue. The positive rates of Twist, MMP-2 and MMP-9 protein expression were 75.5, 97.0 and 96.0%, respectively. Increased expression of Twist was positively correlated with the status of axillary lymph node metastasis and higher tumor-node-metastasis (TNM) stage (P<0.01). Moreover, increased expression of Twist was correlated with poor overall survival (OS) and post-operative relapse-free survival (RFS), compared with those for the patients with reduced expression levels of Twist (P<0.05, P<0.01). The expression of MMP-2 and MMP-9 was positively correlated with Twist expression (P<0.001). Our results indicate that Twist may play an important role in the invasion, metastasis and prognosis of breast cancer. Additionally, our results suggest that Twist may be a regulator of gelatinases (MMP-2 and MMP-9).

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