Stimulation of insulin secretion by large-dose oral arginine administration in healthy adults

Tang,Zhu-Qi; Wu,Tao; Cui,Shi-Wei; Zhu,Xiao-Hui; Yin,Tong; Wang,Cui-Fang; Zhu,Jing-Yi; Wu,Ai-Juan

doi:10.3892/etm.2013.1119

Stimulation of insulin secretion by large-dose oral arginine administration in healthy adults

Authors:
- Zhu-Qi Tang
- Tao Wu
- Shi-Wei Cui
- Xiao-Hui Zhu
- Tong Yin
- Cui-Fang Wang
- Jing-Yi Zhu
- Ai-Juan Wu
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Affiliations: Department of Endocrinology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Nephrology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
Published online on: May 16, 2013 https://doi.org/10.3892/etm.2013.1119
Pages: 248-252

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Abstract

The effects of large-dose oral arginine administration on the secretion of insulin by islet β-cells in healthy adults were determined. Eight non-obese healthy volunteers with normal glucose tolerance participated randomly in tests with four stages (with an interval of at least 3 days): the 300 ml purified water stage (PWS), the 75 g glucose stage (GSS), the 30 g arginine stage (ARS) and the 75 g glucose with 30 g arginine stage (GAS). Venous blood samples were collected to detect the concentrations of glucose and insulin at baseline (0) and at 15, 30, 45, 60 and 120 min after drug administration. The glucose and insulin levels were steady in the PWS. The remaining three stages had similarly shaped insulin concentration‑time curves, which differed from that of the PWS. The peak concentration of blood insulin and the net incremental area under the curve of blood insulin in the GSS, ARS and GAS were significantly higher compared with those in the PWS (P<0.05). In the ARS, the glucose levels remained stable; however, the net incremental area under the curve for blood insulin in the ARS was much lower compared with that in the GSS or GAS (P<0.05). Large-dose oral arginine administration may slightly stimulate insulin secretion by islet β-cells in healthy adults with normal glucose tolerance in a manner that is independent of glucose concentration.

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