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Article

Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients

  • Authors:
    • Chenyun Xia
    • Mi Wang
    • Qi Liang
    • Ling'an Yun
    • Housheng Kang
    • Lei Fan
    • Dongsheng Wang
    • Guoyuan Zhang
  • View Affiliations / Copyright

    Affiliations: Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Nephropathy, People's Hospital of Peking University, Beijing 100044, P.R. China
  • Pages: 137-140
    |
    Published online on: October 22, 2013
       https://doi.org/10.3892/etm.2013.1356
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Abstract

The aim of this study was to investigate changes in human leukocyte antigen (HLA)‑DR expression of peripheral blood mononuclear cells (MNCs) in patients with acute organophosphorus pesticide poisoning (AOPP). HLA‑DR antigen expression of peripheral blood MNCs was examined in 75 patients with AOPP, including 36 patients without multiple organ dysfunction syndrome (non‑MODS) and 39 patients with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy individuals using flow cytometry assay. The associations between HLA‑DR antigen expression and certain parameters were analyzed, including acute physiology and chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney function. The mean fluorescence intensity (MCF) of HLA‑DR expression in the AOPP group (21.59±5.36) was significantly lower than that in the control group (27.85±4.86) (P<0.001). The MCF in the MODS group (18.17±4.23) was lower than that in the non‑MODS group (25.15±6.15). In addition, the MCF of the deceased patients (15.29±3.97) was lower than that of the surviving patients (22.34±2.76) (P<0.001). The MCF of patients with AOPP and MODS was positively correlated with serum ChE (P<0.01) and negatively correlated with the APACHE II score, creatine kinase isoenzyme, cTnI, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen and serum creatinine (P<0.05). In conclusion, HLA‑DR expression in patients with AOPP was significantly decreased compared with that in healthy individuals; HLA‑DR expression may therefore be a good indicator for evaluating AOPP, MODS disease severity, immune function, efficacy of prognosis and prognosis. Examination of HLA‑DR antigen expression may be of crucial clinical value.
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1 

Cavaliere MJ, Puga FR, Calore EE, et al: Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds. J Toxicol Clin Toxicol. 36:295–300. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Mizuno Y, Ohama E, Hirato J, et al: Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease. J Neurol Sci. 246:131–137. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Lukaszewicz AC, Faivre V and Payen D: Is monocyte HLA-DR expression monitoring a useful tool to predict the risk of secondary infection? Minerva Anestesiol. 76:737–743. 2010.PubMed/NCBI

4 

Itakura Sumi Y, Ogura H, Tanaka H, et al: Paradoxical cytoskeleton and microparticle formation changes in monocytes and polymorphonuclear leukocytes in severe systemic inflammatory response syndrome patients. J Trauma. 55:1125–1132. 2003.

5 

Ono S, Tsujimoto H, Matsumoto A, Ikuta S, Kinoshita M and Mochizuki H: Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber. Am J Surg. 188:150–156. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine. Chest. 101:1644–1655. 1992. View Article : Google Scholar

7 

Knaus WA, Draper EA, Wagner DP and Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med. 13:818–829. 1985. View Article : Google Scholar : PubMed/NCBI

8 

Chiba M, Ishii N, Ishioka T, et al: Topographic study of Helicobacter pylori and HLA-DR antigen expression on gastric epithelium. J Gastroenterol. 30:149–155. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Wakefield CH, Carey PD, Foulds S, Monson JR and Guillou PJ: Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg. 80:205–209. 1993. View Article : Google Scholar

10 

Klava A, Windsor A, Boylston AW, Reynolds JV, Ramsden CW and Guillou PJ: Monocyte activation after open and laparoscopic surgery. Br J Surg. 84:1152–1156. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Tschoeke SK and Ertel W: Immunoparalysis after multiple trauma. Injury. 38:1346–1357. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Cheron A, Floccard B, Allaouchiche B, et al: Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care. 14:R2082010. View Article : Google Scholar : PubMed/NCBI

13 

Ho YP, Sheen IS, Chiu CT, Wu CS and Lin CY: A strong association between down-regulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis. Am J Gastroenterol. 101:1117–1124. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Chadban SJ, Tesch GH, Foti R, Lan HY, Atkins RC and Nikolic-Paterson DJ: Interleukin-10 differentially modulates MHC class II expression by mesangial cells and macrophages in vitro and in vivo. Immunology. 94:72–78. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Otsuka A, Hanafusa T, Kono N and Tarui S: Lipopolysaccharide augments HLA-A,B,C molecule expression but inhibits interferon-gamma-induced HLA-DR molecule expression on cultured human endothelial cells. Immunology. 73:428–432. 1991.

16 

Hershman MJ, Cheadle WG, Wellhausen SR, Davidson PF and Polk HC Jr: Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg. 77:204–207. 1990. View Article : Google Scholar : PubMed/NCBI

17 

Melhus O, Koerner TJ and Adams DO: Effects of TNF alpha on the expression of class II MHC molecules in macrophages induced by IFN gamma: evidence for suppression at the level of transcription. J Leukoc Biol. 49:21–28. 1991.PubMed/NCBI

18 

Bone RC, Grodzin CJ and Balk RA: Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 112:235–243. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Volk HD, Reinke P and Döcke WD: Clinical aspects: from systemic inflammation to ‘immunoparalysis’. Chem Immunol. 74:162–177. 2000.

20 

Lekkou A, Karakantza M, Mouzaki A, Kalfarentzos F and Gogos CA: Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol. 11:161–167. 2004.PubMed/NCBI

21 

Ploder M, Pelinka L, Schmuckenschlager C, et al: Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients. Shock. 25:129–134. 2006.

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Copy and paste a formatted citation
Spandidos Publications style
Xia C, Wang M, Liang Q, Yun L, Kang H, Fan L, Wang D and Zhang G: Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients. Exp Ther Med 7: 137-140, 2014.
APA
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L. ... Zhang, G. (2014). Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients. Experimental and Therapeutic Medicine, 7, 137-140. https://doi.org/10.3892/etm.2013.1356
MLA
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L., Wang, D., Zhang, G."Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients". Experimental and Therapeutic Medicine 7.1 (2014): 137-140.
Chicago
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L., Wang, D., Zhang, G."Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients". Experimental and Therapeutic Medicine 7, no. 1 (2014): 137-140. https://doi.org/10.3892/etm.2013.1356
Copy and paste a formatted citation
x
Spandidos Publications style
Xia C, Wang M, Liang Q, Yun L, Kang H, Fan L, Wang D and Zhang G: Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients. Exp Ther Med 7: 137-140, 2014.
APA
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L. ... Zhang, G. (2014). Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients. Experimental and Therapeutic Medicine, 7, 137-140. https://doi.org/10.3892/etm.2013.1356
MLA
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L., Wang, D., Zhang, G."Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients". Experimental and Therapeutic Medicine 7.1 (2014): 137-140.
Chicago
Xia, C., Wang, M., Liang, Q., Yun, L., Kang, H., Fan, L., Wang, D., Zhang, G."Changes in monoclonal HLA‑DR antigen expression in acute organophosphorus pesticide‑poisoned patients". Experimental and Therapeutic Medicine 7, no. 1 (2014): 137-140. https://doi.org/10.3892/etm.2013.1356
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