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Article

Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues

  • Authors:
    • Gongli Yang
    • Qinhua Tan
    • Yongmei Xie
    • Bin Wei
    • Zhixin Chen
    • Chengwei Tang
    • Shengbao Li
    • Chunhui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Gastroenterology, Taihe Hospital, Hubei Medical University, Shiyan, Hubei 442000, P.R. China
  • Pages: 241-245
    |
    Published online on: October 24, 2013
       https://doi.org/10.3892/etm.2013.1361
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Abstract

Nonsteroidal anti‑inflammatory drug‑activated gene‑1 (NAG‑1), a member of the transforming growth factor β (TGF‑β) superfamily, has been demonstrated to possess antitumorigenic and proapoptotic activities in gastric cancer cells. In the present study, the expression of NAG‑1 was assessed in human gastric carcinoma, tumor‑adjacent normal tissues and normal gastric mucosa, with the aim to investigate the role of NAG‑1 in the carcinogenesis and development of gastric carcinoma. NAG‑1 protein expression was evaluated using immunohistochemical staining, while the expression of NAG‑1 mRNA was evaluated using reverse transcription‑polymerase chain reaction. It was observed that adenocarcinoma tissues had a lower expression of NAG‑1 than normal gastric tissues. Furthermore, moderately and well‑differentiated adenocarcinoma tissues expressed more NAG‑1 protein than the poorly differentiated adenocarcinoma tissues. The expression of NAG‑1 protein in adenocarcinoma tissues did not correlate with tumor‑node‑metastasis staging, infiltration degree or tumor size. The NAG‑1 mRNA expression in adenocarcinoma tissues was also lower than that in normal gastric tissues. In conclusion, NAG‑1 was poorly expressed in adenocarcinoma tissues and inversely correlated with the degree of tumor differentiation. These results indicate that NAG‑1 may have an anti‑oncogenic function in the carcinogenesis and development of gastric carcinoma, and that its attenuated or absent expression may lead to gastric carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang G, Tan Q, Xie Y, Wei B, Chen Z, Tang C, Li S and Wang C: Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues. Exp Ther Med 7: 241-245, 2014.
APA
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C. ... Wang, C. (2014). Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues. Experimental and Therapeutic Medicine, 7, 241-245. https://doi.org/10.3892/etm.2013.1361
MLA
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C., Li, S., Wang, C."Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues". Experimental and Therapeutic Medicine 7.1 (2014): 241-245.
Chicago
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C., Li, S., Wang, C."Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues". Experimental and Therapeutic Medicine 7, no. 1 (2014): 241-245. https://doi.org/10.3892/etm.2013.1361
Copy and paste a formatted citation
x
Spandidos Publications style
Yang G, Tan Q, Xie Y, Wei B, Chen Z, Tang C, Li S and Wang C: Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues. Exp Ther Med 7: 241-245, 2014.
APA
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C. ... Wang, C. (2014). Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues. Experimental and Therapeutic Medicine, 7, 241-245. https://doi.org/10.3892/etm.2013.1361
MLA
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C., Li, S., Wang, C."Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues". Experimental and Therapeutic Medicine 7.1 (2014): 241-245.
Chicago
Yang, G., Tan, Q., Xie, Y., Wei, B., Chen, Z., Tang, C., Li, S., Wang, C."Variations in NAG‑1 expression of human gastric carcinoma and normal gastric tissues". Experimental and Therapeutic Medicine 7, no. 1 (2014): 241-245. https://doi.org/10.3892/etm.2013.1361
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