Plasma orexin‑A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition

Akbulut,Gamze; Gezmen‑Karadağ,Makbule; Ertas,Yasemi̇n; Uyar,Banugül Barut; Yassibas,Emi̇ne; Türközü,Duygu; Çelebi,Feri̇de; Paşaoğlu,Özge Tuğçe; Toka,Onur; Yildiran,Hi̇lal; Şanlier,Nevi̇n; Köktürk,Nurdan

doi:10.3892/etm.2014.1611

Plasma orexin‑A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition

Authors:
- Gamze Akbulut
- Makbule Gezmen‑Karadağ
- Yasemi̇n Ertas
- Banugül Barut Uyar
- Emi̇ne Yassibas
- Duygu Türközü
- Feri̇de Çelebi
- Özge Tuğçe Paşaoğlu
- Onur Toka
- Hi̇lal Yildiran
- Nevi̇n Şanlier
- Nurdan Köktürk
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Affiliations: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06500, Turkey, Department of Statistics, Hacettepe University, Ankara 06800, Turkey, Department of Pulmonary Diseases, Faculty of Medicine, Gazi University, Ankara 06560, Turkey
Published online on: March 10, 2014 https://doi.org/10.3892/etm.2014.1611
Pages: 1617-1624

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Abstract

Orexin‑A and ghrelin are two important polypeptides that stimulate food intake, however, there is a lack of sufficient information concerning their plasma levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the association between plasma orexin‑A and ghrelin levels with food consumption and body composition in patients with stable phase COPD. In total, 40 patients (age, 44‑80 years; male, 31; female 9) who were in the stable phase of COPD were included in the study. Blood samples for plasma orexin‑A and ghrelin analysis were collected after 8‑12 h of fasting; certain anthropometric measurements were obtained and a 24‑h dietary recall was recorded. The mean plasma orexin‑A levels in the male and female patients were 1.3±0.37 and 1.4±0.13 ng/ml, respectively, while the mean plasma ghrelin levels were 25.9±7.31 and 27.3±8.54 ng/ml, respectively. No significant correlation was observed between the body mass index and plasma orexin‑A and ghrelin levels or between the plasma ghrelin levels and dietary nutrient intake (P>0.05). The plasma orexin‑A levels were demonstrated to be higher in patients with a higher dietary total fibre intake (r=0.303, P=0.022). A similar correlation was observed between plasma orexin‑A levels and dietary intake of soluble (r=0.033, P=0.029) and insoluble (r=0.335, P=0.024) fibre, as well as between the daily consumption of calcium and the levels of plasma orexin‑A (r=0.065, P=0.046). Therefore, the results of the present study indicated that a positive correlation existed between dietary nutrient intake and plasma orexin‑A levels in patients with COPD.

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